Aminoacyl-analogues of Mitoxantrone as novel DNA-damaging cytotoxic agents

Arkivoc

Volumn 2004, Issue 5, 2004, Pages 204-218

  Zagotto, Giuseppe ^a   Sissi, Claudia ^a   Gatto, Barbara ^a   Palumbo, Manlio ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Aminoacyl anthraquinones; Chirality; DNA binder; Sequence specificity; Topoisomerase II

Indexed keywords

1,4 BIS[(2 AMINOETHYL)AMINO]5,8 DIHYDROXYANTHRACENE 9,10 DIONE BIS(TRIFLUOROACETATE); 5,8 DIHYDROXYANTHRACENE 9,10 DIONE; AMETANTRONE; AMINO ACID DERIVATIVE; ANTHRACENE DERIVATIVE; CYTOTOXIC AGENT; DEXTRO 1,4 BIS[2 (NALPHA LYSYL)AMINOETHYLAMINO] 5,8 DIHYDROXYANTHRACENE 9,10 DIONE; DEXTRO 1,4 BIS[2 VALYLAMINOETHYLAMINO] 5,8 DIHYDROXYANTHRACENE 9,10 DIONE; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; LEVO 1,4 BIS[2 (NALPHA LYSYL)AMINOETHYLAMINO] 5,8 DIHYDROXYANTHRACENE 9,10 DIONE; LEVO 1,4 BIS[2 VALYLAMINOETHYLAMINO] 5,8 DIHYDROXYANTHRACENE 9,10 DIONE; MITOXANTRONE; NSC 301739NB9; TENIPOSIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHIRALITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA BASE COMPOSITION; DNA DAMAGE; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION; SURFACE CHARGE;

EID: 2942683456     PISSN: 14246376     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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