Neurofilament subunit protein abnormalities in the thalamus in schizophrenia

Thalamus and Related Systems

Volumn 2, Issue 4, 2004, Pages 265-272

  Clinton, Sarah M ^a   Abelson, Sara ^a   Haroutunian, Vahram ^b   Davis, Kenneth ^b   Meador Woodruff, James H ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Dorsomedial nucleus; NF H; NF L; NF M

Indexed keywords

CELL PROTEIN; DOPAMINE 1 RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROFILAMENT PROTEIN; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN SUBUNIT;

ADULT; AGED; BRAIN NERVE CELL; CELL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOSKELETON; FEMALE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; MALE; NEUROCHEMISTRY; NEUROFILAMENT; NEUROPATHOLOGY; NEUROTRANSMISSION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVIEW; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; THALAMUS;

EID: 2942682953     PISSN: 14729288     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tharel.2003.11.001     Document Type: Article

References (64)

1. Andreasen N.C. Arndt S. Swayze V. II Cizadlo T. Flaum M. O'Leary D. Ehrhardt J.C. Yuh W.T. Thalamic abnormalities in schizophrenia visualized through magnetic resonance image averaging Science 266 1994 294-298
2. Andreasen N.C. Ehrhardt J.C. Swayze V.W. II Alliger R.J. Yuh W.T. Cohen G. Ziebell S. Magnetic resonance imaging of the brain in schizophrenia. The pathophysiologic significance of structural abnormalities Arch. Gen. Psychiatry 47 1990 35-44
3. Andreasen N.C. O'Leary D.S. Cizadlo T. Arndt S. Rezai K. Ponto L.L. Watkins G.L. Hichwa R.D. Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry Proc. Natl. Acad. Sci. U.S.A. 93 1996 9985-9990
4. Arnold S.E. Trojanowski J.Q. Gur R.E. Blackwell P. Han L.Y. Choi C. Absence of neurodegeneration and neural injury in the cerebral cortex in a sample of elderly patients with schizophrenia Arch. Gen. Psychiatry 55 1998 225-232
5. Benes F.M. Majocha R. Bird E.D. Marotta C.A. Increased vertical axon numbers in cingulate cortex of schizophrenics Arch. Gen. Psychiatry 44 1987 1017-1021
6. Benes F.M. Sorensen I. Vincent S.L. Bird E.D. Sathi M. Increased density of glutamate-immunoreactive vertical processes in superficial laminae in cingulate cortex of schizophrenic brain Cerebral Cortex 2 1992 503-512
7. Buchsbaum M.S. Hazlett E.A. Positron emission tomography studies of abnormal glucose metabolism in schizophrenia Schizophr. Bull. 24 1998 343-364
8. Buchsbaum M.S. Someya T. Teng C.Y. Abel L. Chin S. Najafi A. Haier R.J. Wu J. Bunney W.E. Jr. PET and MRI of the thalamus in never-medicated patients with schizophrenia Am. J. Psychiatry 153 1996 191-199
9. Byne W. Buchsbaum M.S. Mattiace L.A. Hazlett E.A. Kemether E. Elhakem S.L. Purohit D.P. Haroutunian V. Jones L. Postmortem assessment of thalamic nuclear volumes in subjects with schizophrenia Am. J. Psychiatry 159 2002 59-65
10. Clinton S.M. Haroutunian V. Davis K.L. Meador-Woodruff J.H. Altered expression of NMDA receptor-associated post-synaptic density proteins in the thalamus in schizophrenia Am. J. Psychiatry 160 2003 1100-1109
11. Clinton S.M. Meador-Woodruff J.H. Nucleus-specific expression of NMDA receptor-associated postsynaptic density proteins in primate thalamus Thalamus Relat. Syst. 1 2002 303-316
12. Clinton S.M. Meador-Woodruff J.H. 2003 Thalamic dysfunction in schizophrenia: neurochemical, neuropathological, and in vivo imaging abnormalities, Schizophr. Res., in press.
13. Cohen B. Wan W. The thalamus as a site of action of antipsychotic drugs Am. J. Psychiatry 153 1996 104-106
14. Danos P. Baumann B. Kramer A. Bernstein H.G. Stauch R. Krell D. Falkai P. Bogerts B. Volumes of association thalamic nuclei in schizophrenia: a postmortem study Schizophr. Res. 60 2003 141-155
15. Dasari M. Friedman L. Jesberger J. Stuve T.A. Findling R.L. Swales T.P. Schulz S.C. A magnetic resonance imaging study of thalamic area in adolescent patients with either schizophrenia or bipolar disorder as compared to healthy controls Psychiatry Res. 91 1999 155-162
16. Deutch A. Ongur D. Duman R. Antipsychotic drugs induce Fos protein in the thalamic paraventricular nucleus: a novel antipsychotic drug action Neuroscience 66 1995 337-346
17. Dwork A.J. Susser E.S. Keilp J. Waniek C. Liu D. Kaufman M. Zemishlany Z. Prohovnik I. Senile degeneration and cognitive impairment in chronic schizophrenia Am. J. Psychiatry 155 1998 1536-1543
18. Ehlers M. Fung E. O'Brien R. Huganir R. Splice variant-specific interaction of the NMDA receptor subunit NR1 with neuronal intermediate filaments J. Neurosci. 18 1998 720-730
19. Ehlers M.D. Tingley W.G. Huganir R.L. Regulated subcellular distribution of the NR1 subunit of the NMDA receptor Science 269 1995 1734-1737
20. Ettinger U. Chitnis X.A. Kumari V. Fannon D.G. Sumich A.L. O'Ceallaigh S. Doku V.C. Sharma T. Magnetic resonance imaging of the thalamus in first-episode psychosis Am. J. Psychiatry 158 2001 116-118
21. Falke E. Han L.Y. Arnold S.E. Absence of neurodegeneration in the thalamus and caudate of elderly patients with schizophrenia Psychiatry Res. 93 2000 103-110
22. Flaum M. Swayze V.W. II O'Leary D.S. Yuh W.T. Ehrhardt J.C. Arndt S.V. Andreasen N.C. Effects of diagnosis, laterality, and gender on brain morphology in schizophrenia Am. J. Psychiatry 152 1995 704-714
23. Gilbert A.R. Rosenberg D.R. Harenski K. Spencer S. Sweeney J.A. Keshavan M.S. Thalamic volumes in patients with first-episode schizophrenia Am. J. Psychiatry 158 2001 618-624
24. Goldstein M.E. Cooper H.S. Bruce J. Carden M.J. Lee V.M. Schlaepfer W.W. Phosphorylation of neurofilament proteins and chromatolysis following transection of rat sciatic nerve J. Neurosci. 7 1987 1586-1594
25. Gonda Y. Nishizawa K. Ando S. Kitamura S. Minoura Y. Nishi Y. Inagaki M. Involvement of protein kinase C in the regulation of assembly-disassembly of neurofilaments in vitro Biochem. Biophys. Res. Commun. 167 1990 1316-1325
26. Grant P. Pant H.C. Neurofilament protein synthesis and phosphorylation J. Neurocytol. 29 2000 843-872
27. Gur R.E. Maany V. Mozley P.D. Swanson C. Bilker W. Gur R.C. Subcortical MRI volumes in neuroleptic-naive and treated patients with schizophrenia Am. J. Psychiatry 155 1998 1711-1717
28. Hashimoto R. Nakamura Y. Komai S. Kashiwagi Y. Matsumoto N. Shiosaka S. Takeda M. Phosphorylation of neurofilament-l during LTD Neuroreport 11 2000a 2739-2742
29. Hashimoto R. Nakamura Y. Komai S. Kashiwagi Y. Tamura K. Goto T. Aimoto S. Kaibuchi K. Shiosaka S. Takeda M. Site-specific phosphorylation of neurofilament-l is mediated by calcium/calmodulin-dependent protein kinase II in the apical dendrites during long-term potentiation J. Neurochem. 75 2000b 373-382
30. Hashimoto R. Nakamura Y. Tsujio I. Tanimukai H. Kudo T. Takeda M. Quantitative analysis of neurofilament proteins in Alzheimer brain by enzyme linked immunosorbent assay system Psychiatry Clin. Neurosci. 53 1999 587-591
31. Hazlett E.A. Buchsbaum M.S. Byne W. Wei T.C. Spiegel-Cohen J. Geneve C. Kinderlehrer R. Haznedar M.M. Shihabuddin L. Siever L.J. Three-dimensional analysis with MRI and PET of the size, shape, and function of the thalamus in the schizophrenia spectrum Am. J. Psychiatry 156 1999 1190-1199
32. Heckers S. Rauch S.L. Goff D. Savage C.R. Schacter D.L. Fischman A.J. Alpert N.M. Impaired recruitment of the hippocampus during conscious recollection in schizophrenia Nat. Neurosci. 1 1998 318-323
33. Herrmann H. Aebi U. Intermediate filaments and their associates: multi-talented structural elements specifying cytoarchitecture and cytodynamics Curr. Opin. Cell Biol. 12 2000 79-90
34. Holcomb H. Cascella N. Thaker G. Medoff D. Dannals R. Tamminga C. Funcitonal sites of neuroleptic drug action in the human brain: PET/FDG studies with and without haloperidol Am. J. Psychiatry 153 1996 41-49
35. Hu Y.Y. He S.S. Wang X.C. Duan Q.H. Khatoon S. Iqbal K. Grundke-Iqbal I. Wang J.Z. Elevated levels of phosphorylated neurofilament proteins in cerebrospinal fluid of Alzheimer's disease patients Neurosci. Lett. 320 2002 156-160
36. Ibrahim H. Hogg A. Healy D. Haroutunian V. Davis K. Meador-Woodruff J. Ionotropic glutamate receptor binding and subunit mRNA expression in thalamic nuclei in schizophrenia Am. J. Psychiatry 157 2000 1811-1823
37. Julien J.P. Neurofilament functions in health and disease Curr. Opin. Neurobiol. 9 1999 554-560
38. Kim O.-J. Ariano M.A. Lazzarini R.A. Levine M.S. Sibley D.R. Neurofilament-M interacts with the D1 dopamine receptor to regulate cell surface expression and desensitization J. Neurosci. 22 2002 5920-5930
39. Kittur S. Hoh J. Endo H. Tourtellotte W. Weeks B.S. Markesbery W. Adler W. Cytoskeletal neurofilament gene expression in brain tissue from Alzheimer's disease patients. Part I. Decrease in NF-L and NF-M message J. Geriatr. Psychiatry Neurol. 7 1994 153-158
40. Konick L.C. Friedman L. Meta-analysis of thalamic size in schizophrenia Biol. Psychiatry 49 2001 28-38
41. 14C-plastic standards for quantitative autoradiography using LKB ultrofilm or amersham hyperfilm Neurosci. Lett. 121 1991 211-214
42. Nakamura Y. Hashimoto R. Kashiwagi Y. Aimoto S. Fukusho E. Matsumoto N. Kudo T. Takeda M. Major phosphorylation site (Ser55) of neurofilament L by cyclic AMP-dependent protein kinase in rat primary neuronal culture J. Neurochem. 74 2000 949-959
43. Niizato K. Arai T. Kuroki N. Kase K. Iritani S. Ikeda K. Autopsy study of Alzheimer's disease brain pathology in schizophrenia Schizophr. Res. 31 1998 177-184
44. Pakkenberg B. Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics Arch. Gen. Psychiatry 47 1990 1023-1028
45. Pakkenberg B. The volume of the mediodorsal thalamic nucleus in treated and untreated schizophrenics Schizophr. Res. 7 1992 95-100
46. Pakkenberg B. Leucotomized schizophrenics lose neurons in the mediodorsal thalamic nucleus Neuropathol. Appl. Neurobiol. 19 1993 373-380
47. Popken G.J. Bunney W.E. Jr. Potkin S.G. Jones E.G. Subnucleus-specific loss of neurons in medial thalamus of schizophrenics Proc. Natl. Acad. Sci. U.S.A. 97 2000 9276-9280
48. Purohit D.P. Perl D.P. Haroutunian V. Powchik P. Davidson M. Davis K.L. Alzheimer's disease and related neurodegenerative diseases in elderly patients with schizophrenia: a postmortem neuropathologic study of 100 cases Arch. Gen. Psychiatry 55 1998 205-211
49. Rempel H. Kusdra L. Pulliam L. Interleukin-1beta up-regulates expression of neurofilament light in human neuronal cells J. Neurochem. 78 2001 640-645
50. Resnick S.M. Gur R.E. Alavi A. Gur R.C. Reivich M. Positron emission tomography and subcortical glucose metabolism in schizophrenia Psychiatry Res. 24 1988 1-11
51. Rosengren L.E. Karlsson J.E. Karlsson J.O. Persson L.I. Wikkelso C. Patients with amyotrophic lateral sclerosis and other neurodegenerative diseases have increased levels of neurofilament protein in CSF J. Neurochem. 67 1996 2013-2018
52. Shaw G. 1991 Neurofilament proteins. In: Burgoyne, R.D. (Ed.), The Neuronal Cytoskeleton. Wiley-Liss Inc., New York, pp. 621-635.
53. Shenolikar S. Protein serine/threonine phosphatases-new avenues for cell regulation Ann. Rev. Cell Biol. 10 1994 55-86
54. Silbersweig D.A. Stern E. Frith C. Cahill C. Holmes A. Grootoonk S. Seaward J. McKenna P. Chua S.E. Schnorr L. et al. A functional neuroanatomy of hallucinations in schizophrenia Nature 378 1995 176-179
55. Smith R.E. Haroutunian V. Davis K.L. Meador-Woodruff J.H. Expression of excitatory amino acid transporter transcripts in the thalamus of subjects with schizophrenia Am. J. Psychiatry 158 2001a 1393-1399
56. Smith R.E. Haroutunian V. Davis K.L. Meador-Woodruff J.H. Vesicular glutamate transporter transcript expression in the thalamus in schizophrenia Neuroreport. 12 2001b 2885-2887
57. Staal W.G. Hulshoff Pol H.E. Schnack H. van der Schot A.C. Kahn R.S. Partial volume decrease of the thalamus in relatives of patients with schizophrenia Am. J. Psychiatry 155 1998 1784-1786
58. Tamminga C.A. Thaker G.K. Buchanan R. Kirkpatrick B. Alphs L.D. Chase T.N. Carpenter W.T. Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome Arch. Gen. Psychiatry 49 1992 522-530
59. Terry-Lorenzo R. Inoue M. Connor J. Haystead T. Armbruster B. Gupta R. Oliver C. Shenolikar S. Neurofilament-l is a protein phosphatase-1-binding protein associated with neuronal plasma membrane and post-synaptic density J. Biol. Chem. 275 2000 2139-2446
60. Ulas J. Nguyen L. Cotman C. Chronic haloperidol treatment enhances binding to NMDA receptors in rat cortex Neuroreport 4 1993 1049-1051
61. Vita A. Bressi S. Perani D. Invernizzi G. Giobbio G.M. Dieci M. Garbarini M. Del Sole A. Fazio F. High-resolution SPECT study of regional cerebral blood flow in drug-free and drug-naive schizophrenic patients Am. J. Psychiatry 152 1995 876-882
62. Wang J. Tung Y.C. Wang Y. Li X.T. Iqbal K. Grundke-Iqbal I. Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer's disease brain and in okadaic acid-treated SY5Y cells FEBS Lett. 507 2001 81-87
63. Xu Z. Dong D.L. Cleveland D.W. Neuronal intermediate filaments: new progress on an old subject Curr. Opin. Neurobiol. 4 1994 655-661
64. Young K. Manaye K. Liang C. Hicks P. German D. Reduced number of mediodorsal and anterior thalamic neurons in schizophrenia Biol. Psychiatry 47 2000 944-953