Recovery of glucocorticoid-related loss of synaptic density in the fetal sheep brain at 0.75 of gestation

Neuroscience Letters

Volumn 364, Issue 2, 2004, Pages 130-134

  Colberg, Claudia ^a   Antonow Schlorke, Iwa ^a   Müller, Thomas ^a   Schubert, Harald ^a   Witte, Otto W ^a   Schwab, Matthias ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Brain; Fetus; Glucocorticoids; Sheep; Synaptophysin

Indexed keywords

BETAMETHASONE; GLUCOCORTICOID; HYDROCORTISONE; SYNAPTOPHYSIN;

ARTICLE; BRAIN; CAUDATE NUCLEUS; CONTROLLED STUDY; FETUS; FRONTAL CORTEX; GESTATIONAL AGE; HIPPOCAMPUS; HYPOPHYSIS ADRENAL SYSTEM; IMMUNOREACTIVITY; NEOCORTEX; NERVE INJURY; NONHUMAN; PRIORITY JOURNAL; PUTAMEN; SHEEP;

ANIMALS; BETAMETHASONE; BRAIN; BRAIN CHEMISTRY; FEMALE; GESTATIONAL AGE; GLUCOCORTICOIDS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; IMMUNOHISTOCHEMISTRY; PREGNANCY; SHEEP; SYNAPSES; SYNAPTOPHYSIN;

EID: 2942676965     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2004.04.052     Document Type: Article

References (22)

1. Antonow-Schlorke I., Schwab M., Li C., Nathanielsz P.W. Glucocorticoid exposure at the dose used clinically alters cytoskeletal proteins and presynaptic terminals in the fetal baboon brain. J. Physiol. 547.1:2003;117-123
2. Antonow-Schlorke I., Kühn B., Müller T., Schubert H., Sliwka U., Nathanielsz P.W., Schwab M. Antenatal betamethasone treatment reduces synaptophysin immunoreactivity in presynaptic terminals in the fetal sheep brain. Neurosci. Lett. 297:2001;147-150
3. D.J.P. Barker, Mothers, Babies, and Health in Later Life, Churchill Livingstone, Edinburgh, 1998.
4. Brodhun M., Coksaygen T., Antonow-Schlorke I., Müller T., Schubert H., Patt S., Nathanielsz P.W., Schwab M. Association of programmed cell death and glucocorticoid receptors during brain development in fetal sheep. J. Soc. Gynecol. Invest. 10(Suppl.):2003;72A
5. Challis J.R.G., Brooks A.N. Maturation and activation of hypothalamic-pituitary-adrenal function in fetal sheep. Endocr. Rev. 10:1989;182-202
6. Derks J.B., Giussani D.A., Jenkins S.L., Wentworth R.A., Visser G.H., Padbury J.F., Nathanielsz P.W. A comparative study of cardiovascular, endocrine and behavioural effects of betamethasone and dexamethasone administration to fetal sheep. J. Physiol. 499:1997;217-226
7. Dobbing J., Sands J. Comparative aspects of the brain growth spurt. Early Hum. Dev. 3:1979;79-83
8. Hassan A.H., von Rosenstiel P., Patchev V.K., Holsboer F., Almeida O.F. Exacerbation of apoptosis in the dentate gyrus of the aged rat by dexamethasone and the protective role of corticosterone. Exp. Neurol. 140:1996;43-52
9. R. Jahn, P. De Camilli, Membrane proteins of synaptic vesicles: markers for neurons and endocrine cells; tools for the study of neurosecretion, in: M. Gratzl, K. Langley (Eds.), Markers for Neural and Endocrine Cells. Molecular and Cell Biology, Diagnostic Applications, VCH, Weinheim, New York, Basel, Cambridge, 1991, pp. 25-92.
10. Liggins G.C. Premature delivery of foetal lambs infused with glucocorticoids. J. Endocrinol. 45:1969;515-523
11. Leclerc N., Beesley P.W., Brown I., Colonnier M., Gurd J.W., Paladino T., Hawkes R. Synaptophysin expression during synaptogenesis in the rat cerebellar cortex. J. Comp. Neurol. 280:1989;197-212
12. Martinez G., DiGiacomo C., Carnazza M.L., Sorrenti V., Castana R., Barcellona M.L., Perez Polo J.R., Vanella A. MAP2, synaptophysin immunostaining in rat brain and behavorial modifications after cerebral postischemic reperfusion. Dev. Neurosci. 19:1997;457-464
13. Masliah E., Mallory M., Hansen L., DeTeresa R., Alford M., Terry R.D. Quantitative synaptic alteration in the human neocortex during normal aging. Neurol. 43:1993;192-197
14. Masliah E., Terry R.D., Alford M., DeTeresa R. Quantitative immunohistochemistry of synaptophysin in human neocortex: an alternative method to estimate density of presynaptic terminals in paraffin sections. J. Histochem. Cytochem. 38:1990;837-844
15. McEwen B.S. Non-genomic and genomic effects of steroids on neural activity. TIPS. 12:1991;141-147
16. Mulder E.J., Derks J.B., Visser G.H. Antenatal corticosteroid therapy and fetal behaviour: a randomised study of the effects of betamethasone and dexamethasone. Br. J. Obstet. Gynaecol. 104:1997;1239-1247
17. Navone F., Jahn R., DiGioia G., Stukenbrok H., Greengard P., DeCamilli P. Protein p38: an integral membrane protein specific for small vesicles of neurons and neuroendocrine cells. J. Cell. Biol. 103:1986;2511-2527
18. Sarnat H.B., Born D.E. Synaptophysin immunocytochemistry with thermal intensification: a marker of terminal axonal maturation in the human fetal nervous system. Brain Dev. 21:1999;41-50
19. Schwab M., Antonow-Schlorke I., Kühn B., Müller T., Schubert H., Walter B., Sliwka U., Nathanielsz P.W. Effect of antenatal betamethasone treatment on microtubule associated proteins MAP1B and MAP2 in fetal sheep. J. Physiol. 530:2001;497-506
20. Schwab M., Roedel M., Anwar M.A., Müller T., Schubert H., Buchwalder L.F., Walter B., Nathanielsz P.W. Effects of betamethasone administration to the fetal sheep in late gestation on fetal cerebral blood flow. J. Physiol. 528:2000;619-632
21. Schwab M., Schmidt K., Roedel M., Müller T., Schubert H., Anwar M.A., Nathanielsz P.W. Non-linear changes of electrocortical activity after antenatal betamethasone treatment in fetal sheep. J. Physiol. 531:2001;535-543
22. Welberg L.A.M., Seckl J.R., Holmes M.C. Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: possible implications for behaviour. Neuroscience. 104:2001;71-79