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Volumn 45, Issue 28, 2004, Pages 5453-5455

Synthesis of peptide conjugated chelator oligomers for endoradiotherapy and MRT imaging

Author keywords

Chelating agents; Peptides; Targeting

Indexed keywords

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; INDIUM 111; OCTREOTIDE[3 TYROSINE]; OLIGOMER; YTTRIUM 90;

EID: 2942669881     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.05.034     Document Type: Article
Times cited : (14)

References (20)
  • 4
    • 2942679623 scopus 로고    scopus 로고
    • note
    • 3-octreotide; Fmoc: 9-fluorenylmethyloxycarbonyl; HATU: O-(7-azabenzotriazol-1-yl)-N, N, N′, N′-tetramethyluronium hexafluorophosphate; HBTU: O-(1H-benzotriazol-1-yl)-N, N, N′, N′-tetramethyluronium hexafluorophosphate; ivDde: 1-(4, 4-dimethyl-2, 6-dioxocyclohex-1-ylidene)-3-methylbutyl; TIS: triisoproylsilane; TFA: trifluoroacetic acid
  • 12
    • 2942648843 scopus 로고    scopus 로고
    • Purchased from Novabiochem, Germany
    • Purchased from Novabiochem, Germany
  • 15
    • 2942690111 scopus 로고    scopus 로고
    • Purchased from Macrocyclics, USA
    • Purchased from Macrocyclics, USA
  • 16
    • 2942675203 scopus 로고    scopus 로고
    • note
    • 4 pH 6.5, measuring the absorbancy at 280 nm
  • 17
    • 2942668578 scopus 로고    scopus 로고
    • After lyophilisation 1-3 were obtained as white solids with overall yields of approximately 35%
  • 18
    • 2942642620 scopus 로고    scopus 로고
    • note
    • Molecular weight determinations were carried out on a matrix assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-3, Kratos Instruments) and electrospray mass spectrometry on a Finnigan MAT TSQ 7000
  • 19
    • 2942648844 scopus 로고    scopus 로고
    • note
    • 3 was added. The solution was heated at 95°C for 25 min. A quality control of the radiolabelled peptides performed by HPLC showed yields >95% and a relative distribution of the label in accordance with the relative number of chelator moieties of the different species


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.