The topical application of 2,3,7,8-tetrachlorodibenzo-p-dioxin lacks skin tumor-promoting potency but induces hepatic injury and tumor necrosis factor-α expression in ICR male mice

Food and Chemical Toxicology

Volumn 42, Issue 8, 2004, Pages 1217-1225

  Wu, C H ^a   Chen, H L ^b   Su, H J ^b   Lee, C C ^b   Shen, K T ^b   Ho, W L ^c   Ho, S Y ^b,d   Ho, Y S ^c   Wang, Y J ^b  

^a TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d TAINAN SIN LAU HOSPITAL   (Taiwan)

Author keywords

AHR, aromatic hydrocarbon receptor; CYP1A1, Cytochrome P450 1A1; DMBA, dimethylbenz(a)anthracene; ROS, reactive oxygen species; TCDD, 2,3,7,8 tetrachlorodibenzo p dioxin; TNF , tumor necrosis factor ; TPA, 12 O tetradecanoylphorbol 13 acetate

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; LIVER ENZYME; PROSTAGLANDIN F2 ALPHA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER MODEL; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; FATTY LIVER; INFLAMMATORY INFILTRATE; LIVER INJURY; LIVER NODULE; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PROSTAGLANDIN URINE LEVEL; SKIN CARCINOGENESIS; TUMOR PROMOTION; WASTING SYNDROME;

ADMINISTRATION, TOPICAL; ANIMALS; CYTOCHROME P-450 CYP1A1; DINOPROST; ENVIRONMENTAL POLLUTANTS; HEPATITIS, TOXIC; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; MALE; MICE; MICE, INBRED ICR; PROLIFERATING CELL NUCLEAR ANTIGEN; SKIN NEOPLASMS; TETRACHLORODIBENZODIOXIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 2942661802     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2004.02.022     Document Type: Article

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