Enhanced virulence, airway inflammation and impaired lung function induced by respiratory syncytial virus deficient in secreted G protein

Thorax

Volumn 59, Issue 6, 2004, Pages 517-521

  Schwarze, J ^a,b   Schauer, U ^b  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b ST JOSEF HOSPITAL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 5; METHACHOLINE; CYTOKINE;

AIRWAY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY PLETHYSMOGRAPHY; CELL COUNT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EOSINOPHIL; FEMALE; INFLAMMATORY CELL; LUNG ALVEOLUS CELL; LUNG DISEASE; LUNG FUNCTION; LUNG LAVAGE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN SECRETION; PROVOCATION; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY TRACT INFLAMMATION; VIRUS INFECTION; VIRUS MUTANT; VIRUS TITRATION; VIRUS VIRULENCE; WILD TYPE; ANIMAL; BAGG ALBINO MOUSE; BRONCHITIS; LUNG; METABOLISM; PATHOGENICITY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; BRONCHITIS; CYTOKINES; FEMALE; GTP-BINDING PROTEINS; LUNG; MICE; MICE, INBRED BALB C; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES;

EID: 2942635811     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.2003.017343     Document Type: Article

References (28)

1. Busse WW. Respiratory infections: their role in airway responsiveness and the pathogenesis of asthma. J Allergy Clin Immunol 1990;85:671-83.
2. Cypar D, Stark J, Lemanske RF Jr. The impact of respiratory infections on asthma. Pediatr Clin North Am 1992;39:1259-76.
3. Hendricks DA, Baradaran K, McIntosh K, et al. Appearance of a soluble form of the G protein of respiratory syncytial virus in fluids of infected cells. J Gen Virol 1987;68:1705-14.
4. Alwan WH, Kozlowska WJ, Openshaw PJM. Distinct types of lung disease caused by functional subsets of antiviral T cells. J Exp Med 1994;179:81-89.
5. Johnson TR, Johnson JE, Roberts SR, et al. Priming with secreted glycoprotein G of respiratory syncytial virus (RSV) augments interleukin-5 production and tissue eosinophilia after RSV challenge. J Virol 1998,72:2871-80.
6. Krusat T, Streckert HJ. Heparin-dependent attachment of respiratory syncytial virus (RSV) to host cells. Arch Virol 1997;142:1247-54.
7. Teng MN, Whitehead SS, Collins PL. Contribution of the respiratory syncytial virus G glycoprotein and its secreted and membrane-bound forms to virus replication in vitro and in vivo. Virology 2001;289:283-96.
8. Arnold R, König B, Werchau H, et al. Respiratory syncytial virus deficient in soluble G-protein induced an increased proinflammatory response in human lung epithelial cells. Immunobiology 2003;208:160.
9. Schwarze J, Hamelmann E, Bradley KL, et al. Respiratory syncytial virus infection results in airway hyperresponsiveness and enhanced airway sensitization to allergen. J Clin Invest 1997;100:226-33.
10. Schwarze J, Cieslewicz G, Hamelmann E, et al. IL-5 and eosinophils are essential for the development of airway hyperresponsiveness following acute respiratory syncytial virus infection. J Immunol 1999;162:2997-3004.
11. Reuman PD, Keely SP, Schiff GM. Comparison of class and subclass antibody response to live and UV-inactivated RSV administered intranasally in mice. J Med Virol 1991;35:198-205.
12. Foster S, Bedford KJ, Gould ME, et al. Respiratory syncytial virus infection and virus-induced inflammation are modified by contaminants of indoor air. Immunology 2003;108:109-15.
13. Krah DL. A simplified multiwell plate assay for the measurement of hepatitis A virus infectivity. Biologicals 1991;19:223-7.
14. Hamelmann E, Schwarze J, Takeda K, et al. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med 1997;156:766-75.
15. Oshiba A, Hamelmann E, Takeda K, et al. Passive transfer of immediate hypersensitivity and airway hyperresponsiveness by allergen-specific immunoglobulin (Ig) E and IgG1 in mice. J Clin Invest 1996;97:1398-1408.
16. Tripp RA, Jones LP, Haynes LM, et al. CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein. Nat Immunol 2001;2:732-8.
17. Lalani AS, Masters J, Graham K, et al. Role of the myxoma virus soluble CC-chemokine inhibitor glycoprotein, M-T1, during myxoma virus pathogenesis. Virology 1999;256:233-45.
18. Volchkov VE, Volchkova VA, Muhlberger E, et al. Recovery of infectious Ebola virus from complementary DNA: RNA editing of the GP gene and viral cytotoxicity. Science 2001;291:1965-9.
19. Delgado M, Jonakait GM, Ganea D. Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit chemokine production in activated microglia. Glia 2002;39:148-61.
20. Heath H, Qin S, Rao P, et al. Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody. J Clin Invest 1997;99:178-84.
21. Simmons G, Clapham PR, Picard L, et al. Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist. Science 1997;276:276-9.
22. Sallusto F, Mackay CR, Lanzavecchia A. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science 1997;277:2005-7.
23. Tekkanat KK, Maassab H, Miller A, et al. RANTES (CCL5) production during primary respiratory syncytial virus infection exacerbates airway disease. Eur J Immunol 2002;32:3276-84.
24. Behera AK, Matsuse H, Kumar M, et al. Blocking intercellular adhesion molecule-1 on human epithelial cells decreases respiratory syncytial virus infection. Biochem Biophys Res Commun 2001;280:188-95.
25. Hussell T, Spender LC, Georgiou A, et al. Th1 and Th2 cytokine induction in pulmonary T cells during infection with respiratory syncytial virus. J Gen Virol 1996,77:2447-55.
26. Tripp RA, Moore D, Anderson LJ. TH(1)- and TH(2)-type cytokine expression by activated T lymphocytes from the lung and spleen during the inflammatory response to respiratory syncytial virus. Cytokine 2000;12:801-7.
27. Panuska JR, Merolla R, Rebert NA, et al. Respiratory syncytial virus induces interleukin-10 by human alveolar macrophages. Suppression of early cytokine production and implications for incomplete immunity. J Clin Invest 1995;96:2445-53.
28. Makela MJ, Kanehiro A, Borish L, et al. IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization. Proc Natl Acad Sci USA 2000;97:6007-12.