The Icelandic Cancer Project - A population-wide approach to studying cancer

Nature Reviews Cancer

Volumn 4, Issue 6, 2004, Pages 488-492

  Rafnar, Thorunn ^a   Thorlacius, Steinunn ^a   Steingrimsson, Eirikur ^a   Schierup, Mikkel H ^b   Madsen, Jesper N ^b   Calian, Violeta ^a   Eldon, Bjarki J ^a   Jonsson, Thorvaldur ^c   Hein, Jotun ^b   Thorgeirsson, Snorri S ^d  

^a DECODE GENETICS   (Iceland)

^b Metabolistic ApS   (Denmark)

^c LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER GROWTH; CANCER RISK; CANCER SCREENING; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CLINICAL FEATURE; CORRELATION ANALYSIS; ENVIRONMENTAL FACTOR; GENETIC DATABASE; GENETIC PREDISPOSITION; GENOME ANALYSIS; HEALTH CARE ORGANIZATION; HEREDITY; HUMAN; ICELAND; OUTCOMES RESEARCH; POPULATION RESEARCH; PRIORITY JOURNAL; REVIEW; RISK FACTOR; TECHNIQUE;

EID: 2942622369     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc1371     Document Type: Review

References (18)

1. Rangarajan, A. & Weinberg, R. A. Comparative biology of mouse versus human cells: modelling human cancer in mice. Nature Rev. Cancer 3, 952-959 (2003).
2. Malkin, D. et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250, 1233-1238 (1990).
3. Vasen, H. F. et al. The tumour spectrum in hereditary non-polyposis colorectal cancer: a study of 24 kindreds in the Netherlands. Int. J. Cancer 46, 31-34 (1990).
4. Abbott, A. Manhattan versus Reykjavik. Nature 406, 340-342 (2000).
5. Palsdottir, A. et al. Mutation in cystatin C gene causes hereditary brain haemorrhage. Lancet 2, 603-604 (1988).
6. Kristinsson, S. Y. et al. MODY in Iceland is associated with mutations in HNF-1α and a novel mutation in NeuroD1. Diabetologia 44, 2098-2103 (2001).
7. Stefansson, H. et al. Neuregulin 1 and susceptibility to schizophrenia. Am. J. Hum. Genet. 71, 877-892 (2002).
8. Gretarsdottir, S. et al. The gene encoding phosphodiesterase 4D confers risk of ischemic stroke. Nature Genet. 35, 131-138 (2003).
9. Lichtenstein, P. et al. Environmental and heritable factors in the causation of cancer: analyses of cohorts of twins from Sweden, Denmark, and Finland. N. Engl. J. Med. 343, 78-85 (2000).
10. Peto, J. Breast cancer susceptibility - A new look at an old model. Cancer Cell 1, 411-412 (2002).
11. Risch, N. The genetic epidemiology of cancer: interpreting family and twin studies and their implications for molecular genetic approaches. Cancer Epidemiol. Biomarkers Prev. 10, 733-741 (2001).
12. Cardon, L. R. & Bell, J. I. Association study designs for complex diseases. Nature Rev. Genet. 2, 91-99 (2001).
13. Botstein, D. & Risch, N. Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nature Genet. 33, 228-237 (2003).
14. Shifman, S. & Darvasi, A. The value of isolated populations. Nature Genet. 28, 309-310 (2001).
15. Morris, A. P., Whittaker, J. C. & Balding, D. J. Fine-scale mapping of disease loci via shattered coalescent modeling of genealogies. Am. J. Hum. Genet. 70, 686-707 (2002).
16. Liu, J. S., Sabatti, C., Teng, J., Keats, B. J. & Risch, N. Bayesian analysis of haplotypes for linkage disequilibrium mapping. Genome Res. 11, 1716-1724 (2001).
17. Rannala, B. & Reeve, J. P. High-resolution multipoint linkage-disequilibrium mapping in the context of a human genome sequence. Am. J. Hum. Genet. 69, 159-178 (2001).
18. Thorlacius, S. et al. Population-based study of risk of breast cancer in carriers of BRCA2 mutation. Lancet 352, 1337-1339 (1998).