NMDA lesions in the medial prefrontal cortex impair the ability to inhibit responses during reversal of a simple spatial discrimination

Behavioural Brain Research

Volumn 152, Issue 2, 2004, Pages 413-424

  Salazar, Rodrigo F ^a   White, Wesley ^b   Lacroix, Laurent ^c   Feldon, Joram ^d   White, Ilsun M ^b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b MOREHEAD STATE UNIVERSITY   (United States)

^c GSK   (Italy)

^d ETH ZURICH   (Switzerland)

Author keywords

Openfield activity; Prepulse inhibition; Response inhibition; Spatial learning

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSOCIATION; BRAIN CORTEX LESION; CONTROLLED STUDY; FACILITATION; INHIBITION (PSYCHOLOGY); LEARNING; MALE; NONHUMAN; OPEN FIELD BEHAVIOR; PREFRONTAL CORTEX; PREPULSE INHIBITION; PRIORITY JOURNAL; RAT; SENSORIMOTOR FUNCTION; SPATIAL DISCRIMINATION; TASK PERFORMANCE;

ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; BRAIN DISEASES; DISCRIMINATION LEARNING; EXCITATORY AMINO ACID AGONISTS; MALE; N-METHYLASPARTATE; NEURAL INHIBITION; PREFRONTAL CORTEX; RATS; REVERSAL LEARNING; SPACE PERCEPTION; TIME FACTORS;

EID: 2942620818     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2003.10.034     Document Type: Article

References (46)

1. de Bruin J.P., Sanchez-Santed F., Heinsbroek R.P., Donker A., Postmes P. A behavioural analysis of rats with damage to the medial prefrontal cortex using the Morris water maze: evidence for behavioural flexibility, but not for impaired spatial navigation. Brain Res. 652:1994;323-333
2. de Bruin J.P., Swinkels W.A., de Brabander J.M. Response learning of rats in a Morris water maze: involvement of the medical prefrontal cortex. Behav. Brain Res. 85:1997;47-55
3. Ragozzino M.E., Detrick S., Kesner R.P. Involvement of the prelimbic-infralimbic areas of the rodent prefrontal cortex in behavioral flexibility for place and response learning. J. Neurosci. 19:1999a;4585-4594
4. Kolb B. Functions of the frontal cortex of the rat: a comparative review. Brain Res. 320:1984;65-98
5. Kolb B., Gibb R. Anatomical correlates of behavioural change after neonatal prefrontal lesions in rats. Prog. Brain Res. 85:1990;241-255
6. Neill D.B. Frontal-striatal control of behavioral inhibition in the rat. Brain Res. 105:1976;89-103
7. Bussey T.J., Muir J.L., Everitt B.J., Robbins T.W. Triple dissociation of anterior cingulate, posterior cingulate, and medial frontal cortices on visual discrimination tasks using a touchscreen testing procedure for the rat. Behav. Neurosci. 111:1997;920-936
8. Granon S., Vidal C., Thinus-Blanc C., Changeux J.P., Poucet B. Working memory, response selection, and effortful processing in rats with medial prefrontal lesions. Behav. Neurosci. 108:1994;883-891
9. Winocur G., Eskes G. Prefrontal cortex and caudate nucleus in conditional associative learning: dissociated effects of selective brain lesions in rats. Behav. Neurosci. 112:1998;89-101
10. Murphy B.L., Arnsten A.F., Goldman-Rakic P.S., Roth R.H. Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys. Proc. Natl. Acad. Sci. USA. 93:1996;1325-1329
11. Birrell J.M., Brown V.J. Medial frontal cortex mediates perceptual attentional set shifting in the rat. J. Neurosci. 20:2000;4320-4324
12. Joel D., Tarrasch R., Feldon J., Weiner I. Effects of electrolytic lesions of the medial prefrontal cortex or its subfields on 4-arm baited, 8-arm radial maze, two-way active avoidance and conditioned fear tasks in the rat. Brain Res. 765:1997a;37-50
13. Ragozzino M.E., Wilcox C., Raso M., Kesner R.P. Involvement of rodent prefrontal cortex subregions in strategy switching. Behav. Neurosci. 113:1999b;32-41
14. Kesner R.P. Subregional analysis of mnemonic functions of the prefrontal cortex in the rat. Psychobiol. 28:2000;219-228
15. Divac I. Frontal lobe system and spatial reversal in the rat. Neuropsychologia. 9(2):1971;175-183
16. Kolb B., Nonneman A.J., Singh R.K. Double dissociation of spatial impairments and perseveration following selective prefrontal lesions in rats. J. Comp. Physiol. Psychol. 87:1974;772-780
17. Wolf C., Waksman D., Finger S., Almli C.R. Large and small medial frontal cortex lesions and spatial performance of the rat. Brain Res. Bull. 18:1987;1-5
18. Li L., Shao J. Restricted lesions to ventral prefrontal subareas block reversal learning but not visual discrimination learning in rats. Physiol. Behav. 65:1998;371-379
19. Ferry A.T., Lu X.C., Price J.L. Effects of excitotoxic lesions in the ventral striatopallidal - thalamocortical pathway on odor reversal learning: inability to extinguish an incorrect response. Exp. Brain Res. 131:2000;320-335
20. Joel D., Weiner I., Feldon J. Electrolytic lesions of the medial prefrontal cortex in rats disrupt performance on an analog of the Wisconsin Card Sorting Test, but do not disrupt latent inhibition: implications for animal models of schizophrenia. Behav. Brain Res. 85:1997b;187-201
21. Yee B.K. Cytotoxic lesion of the medial prefrontal cortex abolishes the partial reinforcement extinction effect, attenuates prepulse inhibition of the acoustic startle reflex and induces transient hyperlocomotion, while sparing spontaneous object recognition memory in the rat. Neuroscience. 95:2000;675-689
22. Bakshi V.P., Geyer M.A. Multiple limbic regions mediate the disruption of prepulse inhibition by the noncompetitive NMDA antagonist dizocilpine. J. Neurosci. 18:1998;8394-8401
23. Koch M. The neurobiology of startle. Prog. Neurobiol. 59:1999;107-128
24. Preuss T.M. Do rats have prefrontal cortex? The Rose-Woolsey-Akert Program reconsidered. J. Cogn. Neurosci. 7:1995;1-24
25. Granon S., Poucet B. Involvement of the rat prefrontal cortex in cognitive functions: a central role for the prelimbic area. Psychobiology. 28:2000;229-237
26. Kolb B., Pittman K., Sutherland R.J., Whishaw I.Q. Dissociation of the contributions of the prefrontal cortex and dorsomedial thalamic nucleus to spatially guided behavior in the rat. Behav. Brain Res. 6:1982;365-378
27. Rogers D.C., Wright P.W., Roberts J.C., Reavill C., Rothaul A.L., Hunter A.J. Photothrombotic lesions of the frontal cortex impair the performance of the delayed non-matching to position task by rats. Behav. Brain Res. 49:1992;231-235
28. Harrison L.M., Mair R.G. A comparison of the effects of frontal cortical and thalamic lesions on measures of spatial learning and memory in the rat. Behav. Brain Res. 75:1996;195-206
29. Porter M.C., Burk J.A., Mair R.G. A comparison of the effects of hippocampal or prefrontal cortical lesions on three versions of delayed non-matching-to-sample based on positional or spatial cues. Behav. Brain Res. 109:2000;69-81
30. Dunnett S.B., Nathwani F., Brasted P.J. Medial prefrontal and neostriatal lesions disrupt performance in an operant delayed alternation task in rats. Behav. Brain Res. 106:1999;13-28
31. Kesner R.P. Retrospective and prospective coding of information: role of the medial prefrontal cortex. Exp. Brain Res. 74:1989;163-167
32. Bussey T.J., Muir J.L., Everitt B.J., Robbins T.W. Dissociable effects of anterior and posterior cingulate cortex lesions on the acquisition of a conditional visual discrimination: facilitation of early learning vs. impairment of late learning. Behav. Brain Res. 82:1996;45-56
33. Broersen L.M., Uylings H.B. Visual attention task performance in Wistar and Lister hooded rats: response inhibition deficits after medial prefrontal cortex lesions. Neuroscience. 94:1999;47-57
34. Silva M.G., Boyle M.A., Finger S., Numan B., Bouzrara A.A., Almli C.R. Behavioral effects of large and small lesions of the rat medial prefrontal cortex. Exp. Brain Res. 65:1986;176-181
35. Lacroix L., White I.M., Feldon J. Effects of excitotoxic lesions of rat medial prefrontal cortex on spatial memory. Behav. Brain Res. 133:2002;69-81
36. Salazar R.F., Hedou G., Bonifay C., Feldon J., White I.M. Infusion of a GABAergic agonist into the rat medial prefrontal cortex disrupts performance on a visuospatial discrimination task. Soc. Neurosci. Abstr. 27:2001;4188
37. Lacroix L., Broersen L.M., Weiner I., Feldon J. The effects of excitotoxic lesion of the medial prefrontal cortex on latent inhibition, prepulse inhibition, food hoarding, elevated plus maze, active avoidance and locomotor activity in the rat. Neuroscience. 84:1998;431-442
38. Swerdlow N.R., Lipska B.K., Weinberger D.R., Braff D.L., Jaskiw G.E., Geyer M.A. Increased sensitivity to the sensorimotor gating-disruptive effects of apomorphine after lesions of medial prefrontal cortex or ventral hippocampus in adult rats. Psychopharm. (Berl.). 122(1):1995;27-34
39. Lacroix L., Spinelli S., White W., Feldon J. The effects of ibotenic acid lesions of the medial and lateral prefrontal cortex on latent inhibition, prepulse inhibition and amphetamine-induced hyperlocomotion. Neuroscience. 97:2000;459-468
40. Bubser M., Koch M. Prepulse inhibition of the acoustic startle response of rats is reduced by 6-hydroxydopamine lesions of the medial prefrontal cortex. Psychopharmacol. (Berl.). 113:1994;487-492
41. Bubser M., Schmidt W.J. 6-Hydroxydopamine lesion of the rat prefrontal cortex increases locomotor activity, impairs acquisition of delayed alternation tasks, but does not affect uninterrupted tasks in the radial maze. Behav. Brain Res. 37:1990;157-168
42. Tzschentke T.M., Schmidt W.J. Discrete quinolinic acid lesions of the rat prelimbic medial prefrontal cortex affect cocaine- and MK-801, but not morphine- and amphetamine-induced reward and psychomotor activation as measured with the place preference conditioning paradigm. Behav. Brain Res. 97:1998;115-127
43. Burns L.H., Annett L., Kelley A.E., Everitt B.J., Robbins T.W. Effects of lesions to amygdala, ventral subiculum, medial prefrontal cortex, and nucleus accumbens on the reaction to novelty: implication for limbic-striatal interactions. Behav. Neurosci. 110:1996;60-73
44. Isaac W.L., Nonneman A.J., Neisewander J., Landers T., Bardo M.T. Prefrontal cortex lesions differentially disrupt cocaine-reinforced conditioned place preference but not conditioned taste aversion. Behav. Neurosci. 103:1989;345-355
45. Jaskiw G.E., Weinberger D.R. Ibotenic acid lesions of medial prefrontal cortex augment swim-stress-induced locomotion. Pharmacol. Biochem. Behav. 41:1992;607-609
46. Braun A.R., Jaskiw G.E., Vladar K., Sexton R.H., Kolachana B.S., Weinberger D.R. Effects of ibotenic acid lesion of the medial prefrontal cortex on dopamine agonist-related behaviors in the rat. Pharmacol. Biochem. Behav. 46:1993;51-60