Disruption of the RAD51 gene sensitizes S. cerevisiae cells to the toxic and mutagenic effects of hydrogen peroxide

Folia Microbiologica

Volumn 49, Issue 3, 2004, Pages 259-264

  Dudasova Z ^a   Dudas A ^a   Alemayehu, A ^b   Vlasakova D ^a   Markova E ^a   Chovanec, M ^a   Vlckova V ^b   Brozmanova J ^a  

^a CANCER RESEARCH INSTITUTE   (Slovakia)

^b Physics and Informatics   (Slovakia)

Author keywords

[No Author keywords available]

Indexed keywords

PROKARYOTA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 2942614997     PISSN: 00155632     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02931040     Document Type: Article

References (35)

1. ABE H., WADA M., KOHNO K., KUVANO M.: Altered drug sensitivities to anticancer agents in radiation-sensitive DNA repair deficient yeast mutants. Anticancer Res. 14, 1807-1810 (1994).
2. BASILE G., AKER M., MORTIMER R.K.: Nucleotide sequence and transcriptional regulation by the yeast recombinational repair gene RAD51. Mol.Cell.Biol. 12, 3235-3246 (1992).
3. BAUMANN P., WEST S.C.: Role of the human RAD51 protein in homologous recombination and double-stranded break repair. Trends Biochem.Sci. 23, 247-251 (1998).
4. BIANCO P.R., TRACY R.B., KOWALCZYKOWSKI S.C.: DNA strand exchange proteins: a biochemical and physical comparison. Front. Biosci. 3, 570-603 (1998).
5. BROZMANOVÁ J., VLČKOVÁ V., FARKAŠOVÁ E., DUDÁŠ A., VLASÁKOVÁ D., CHOVANEC M., MIKULOVSKÁ Z., FRIDRICHOVÁ I., SAFFI J., HENRIQUES J.A.P.: Increased DNA double strand breakage is responsible for sensitivity of the pso3-1 mutant of Saccharomyces cerevisiae to hydrogen peroxide. Mutat.Res. 485, 345-355 (2001).
6. + gene product is more important than catalase and superoxide dismutase in protecting Escherichia coli against hydrogen peroxide toxicity. J.Bacteriol. 142, 319-321 (1980).
7. DEMPLE B., HARRISON L.: Repair of oxidative damage to DNA: enzymology and biology. Ann.Rev.Biochem. 63, 915-948 (1994).
8. DOETSCH P.W., MOREY N.J., SWANSON R.L., JINKS-ROBERTSON S.: Yeast base excision repair: interconnections and networks. Progr.Nucl.Acids Res.Mol.Biol. 68, 29-39 (2001).
9. DONOVAN J.W., MILNE G.T., WEAVER D.T.: Homotypic and heterotypic protein associations control Rad51 function in double-strand break repair. Gene Dev. 8, 2552-2562 (1994).
10. DUDÁŠ A., CHOVANEC M.: DNA double-strand break repair by homologous recombination. Mutat.Res. 566, 131-167 (2004).
11. GAME J.C.: The Saccharomyces repair genes at the end of the century. Mutat.Res. 451, 277-293 (2000).
12. GAME J.C., MORTIMER R.K.: A genetic study of X-ray sensitive mutants in yeast. Mutat.Res. 24, 281-292 (1974).
13. GASCH A.P., HUANG M., METZNER S., BOTSTEIN D., ELLEDGE S.J., BROWN P.O.: Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p. Mol.Biol.Cell 12, 2987-3003 (2001).
14. HAGENSEE M.E., MOSES R.E.: Repair response of Escherichia coli to hydrogen peroxide DNA damage. J.Bacteriol. 168, 1059-1065 (1986).
15. IMLAY J.A., LINN S.: Mutagenesis and stress responses induced in Escherichia coli by hydrogen peroxide. J.Bacteriol. 169, 2967-2976 (1987).
16. KONOLA J.T., SARGENT K.E., GOW J.-B.: Efficient repair of hydrogen peroxide-induced DNA damage by Escherichia coli requires SOS induction of RecA and RuvA proteins. Mutat.Res. 459, 187-194 (2000).
17. KOWALCZYKOWSKI S.C., DIXON D.A., EGGLESTON A.K., LAUDER S.D., REHRAUER W.M.: Biochemistry of homologous recombination in Escherichia coli. Microbiol.Rev. 58, 401-465 (1994).
18. KRISTOFFER V., POVIRK L.F.: Regulation and mechanisms of mammalian double-strand break repair. Oncogene 22, 5792-5812 (2003).
19. LUNDIN C., SCHULTZ N., ARNAUDEAU C., MOHINDRA A., HANSEN L.T., HELLEDAY T.: RAD51 is involved in repair of damage associated with DNA replication in mammalian cells. J.Mol.Biol. 328, 521-535 (2003).
20. MEMISOGLU A., SAMSON L.: Base excision repair in yeast and mammals. Mutat.Res. 451, 39-51 (2000).
21. MERCIER G., DENIS Y., MARC P., PICARD L., DUTREIX M.: Transcriptional induction of repair genes during slowing of replication in irradiated Saccharomyces cerevisiae. Mutat.Res. 487, 157-172 (2001).
22. MOORE C.W.: Responses of radiation-sensitive mutants of Saccharomyces cerevisiae to lethal effects of bleomycin. Mutation Res. 51, 165-180 (1978).
23. MORAIS M.A., VICENTE E.J., BROZMANOVÁ J., SCHENBERG A.C., HENRIQUES J.A.P.: Further characterization of the yeast pso4-1 mutant: interaction with rad51 and rad52 mutants after photoinduced psoralen lesions. Curr.Genet. 29, 211-218 (1996).
24. MORAIS M.A., VLČKOVÁ V., FRIDRICHOVÁ I., SLANINOVÁ M., BROZMANOVÁ J., HENRIQUES J.A.P.: Effect of bacterial recA expression on DNA repair in the rad51 and rad52 mutants of Saccharomyces cerevisiae. Genet.Mol.Biol. 21, 3-9 (1998).
25. OGAWA T., SHINOHARA A., NABETANI A., IKEYA T., YU X., EGELMAN E.H., OGAWA H.: RecA-like recombination proteins in eukaryotes: functions and structures of RAD51 genes. Cold Spring Harbor Symp.Quant.Biol. 68, 567-576 (1993).
26. PAQUES F., HABER J.E.: Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol.Mol.Biol.Rev. 63, 349-404 (1999).
27. ŠKORVAGA M., ČERNÁKOVÁ L., CHOVANEC M., KLEIBL K., HENDRY J.H., MARGISON G.P., BROZMANOVÁ J.: Effect of expression of the Escherichia coli nth gene in Saccharomyces cerevisiae on the toxicity of ionizing radiation and hydrogen peroxide. Radiat.Res. 79, 747-755 (2003).
28. SUNG P., TRUJILLO K.M., VANKOMEN S.: Recombination factors of Saccharomyces cerevisiae. Mutat.Res. 451, 257-275 (2000).
29. SUNG P., KREJČI L., VANKOMEN S., SEHORN M.G.: Rad51 recombinase and recombination mediators. J.Biol.Chem. 278, 42729-42732 (2003).
30. SWANSON R.L., MOREY N.J., DOETSCH P.W., JINKS-ROBERTSON S.: Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae. Mol.Cell.Biol. 19, 2929-2935 (1999).
31. SYMINGTON L.S.: Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair. Microbiol.Mol.Biol.Rev. 66, 630-670 (2002).
32. VANDENBOSCH M., LOHMAN P.H.M., PASTINK A.: DNA double-strand break repair by homologous recombination. Biol.Chem. 383, 873-892 (2002).
33. VISPE S., DEFAIS M.: Mammalian Rad51 protein: a RecA homologue with pleiotropic functions. Biochimie 79, 587-592 (1997).
34. WALLACE S.S.: Enzymatic processing of radiation-induced free radical damage in DNA. Radiat.Res. 150, 60-79 (1998).
35. WALLACE S.S.: Biological consequences of free radical-damaged DNA bases. Free Radical Biol.Med. 33, 1-14 (2002).