Of mice, men, and hormones

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 24, Issue 6, 2004, Pages 995-997

  Miller, Virginia M ^a   Tindall, Donald J ^a   Liu, Peter Y ^a  

^a Mayo Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA;

ATHEROMA; ATHEROSCLEROSIS; EDITORIAL; ENVIRONMENTAL FACTOR; GENDER; HEART PROTECTION; HEREDITY; HORMONAL REGULATION; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; TESTIS FUNCTION;

ANIMALS; ARTERIOSCLEROSIS; COHORT STUDIES; DISEASE SUSCEPTIBILITY; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGENS; FEMALE; HUMANS; MALE; MICE; MODELS, BIOLOGICAL; ORCHIECTOMY; RECEPTORS, ESTROGEN; SEX CHARACTERISTICS; SPECIES SPECIFICITY; TESTOSTERONE;

EID: 2942605834     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000130660.53541.a4     Document Type: Editorial

References (37)

1. Vargas CM, Burt VL, Gillum RF. Cardiovascular disease in the NHANES III. Ann Epidemil. 1997;7:523-525.
2. Nagel SC, vom Saal FS. Endocrine control of sexual differentiation: effects of the matemal-fetal environment and endocrine disrupting chemicals. In: VM Miller and M Hay, eds. Principles of Sex-Based Differences in Physiology. Volume 34 of: EG Bittar, Series Ed. Advances in Molecular and Cell Biology. The Netherlands: Elsevier Science; 2004:15-37.
3. Liu PY, Death AK, Handelsman DJ. Androgens and cardiovascular disease. Endocrine Reviews. 2003;24:313-340.
4. Villablanca A, Lubahn D, Shelby L, Lloyd K, Barthold S. Susceptibility to early atherosclerosis in male mice is mediated by estrogen receptor α. Arterioscler Thromb Vasc Biol. 2004;24:1055-1061.
5. Barrett-Connor E, Bush TL. Estrogen and coronary heart disease in women. JAMA. 1991;265:1861-1867.
6. Kannel WB, Hjortland MC, McNamara PM, Gordon T. Menopause and risk of cardiovascular disease: the Framingham Study. Ann Int Med. 1976;85:447-452.
7. Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. N Engl J Med. 1999;340:1801-1811.
8. Lew R, Komesaroff PA, Williams M, Dawood T, Sudhir K. Endogenous estrogens influence endothelial function in young men. Circ Res. 2003;93: 1127-1133.
9. Hodges YK, Tung L, Yan X-D, Graham D, Horwitz KB, Horwitz LD. Estrogen receptors α and β. Prevalence of estrogen receptor β mRNA in human vascular smooth muscle and transcriptional effects. Circulation. 2000;101: 1792-1798.
10. Sudhir K, Chou TM, Messina LM, Hutchison SJ, Korach KS, Chatterjee K, Rubanyi GM. Endothelial dysfunction in a man with disruptive mutation in oestrogen-receptor gene. Lancet. 1997;349:1146-1147.
11. Shearman AM, Cupples LA, Demissie S, Peter I, Schmid CH, Karas RH, Mendelsohn ME, Housman DE, Levy D. Association between estrogen receptor α gene variation and cardiovascular disease. JAMA. 2003;290:2263-2270.
12. Sudhir K, Chou TM, Chatterjee K, Smith EP, Williams TC, Kane JP, Malloy MJ, Korach KS, Rubanyi GM. Premature coronary artery disease associated with a disruptive mutation in the estrogen receptor gene in a man. Circulation. 1997; 96:3774-3777.
13. Kunnas TA, Laippala P, Penttila A, Lehtimaki T, Karhunen PJ. Association of polymorphism of human α oestrogen receptor gene with coronary artery disease in men: A necropsy study. BMJ. 2000;321:273-274.
14. Couse JF, Curtis SW, Washburn TF, Lindzey J, Golding TS, Lubahn DB, Smithies O, Korach KS. Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene. Mol Endocrinol. 1995;9:1441-1454.
15. Toran-Allerand CD, Guan X, MacLusky NJ, Horvath TL, Diano S, Singh M, Connolly ESJ, Nethrapalli IS, Tinnikov AA. ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury. J Neurosci. 2002;22:8391-8401.
16. Pare G, Krust A, Karas RH, Dupont S, Aronovitz M, Chambon P, Mendelsohn ME. Estrogen receptor-α mediates the protective effects of estrogen against vascular injury. Circ Res. 2002;90:1087-1092.
17. Shearman AM. Hormone receptor polymorphisms. In: VM Miller and M Hay, eds. Principles of Sex-Based Differences in Physiology. Volume 34 of: EG Bittar, Series Ed. Advances in Molecular and Cell Biology The Netherlands: Elsevier Science; 2004:59-69.
18. Death AK, McGrath KC, Sader MA, Nakhla S, Jessup W, Handelsman DJ, Celermajer DS. Dihydrotestosterone promotes vascular cell adhesion molecule-1 expression in male human endothelial cells via a nuclear factor{kappa}B-dependent pathway. Endocrinology. 2004;145:1889-1897.
19. Wang X, Barber DA, Lewis DA, McGregor CGA, Sieck GC, Fitzpatrick LA, Miller VM. Gender and transcriptional regulation of endothelial nitric oxide synthase and endothelin-1 in porcine aortic endothelial cells. Am J Physiol. 1998;273:H1962-H1967.
20. Barber DA, Miller VM. Gender differences in endothelium dependent relaxations do not involve NO in porcine coronary arteries. Am J Physiol. 1997;273: H2325-H2332.
21. Barber DA, Burnett JC Jr., Fitzpatrick LA, Sieck GC, Miller VM. Gender and relaxation to C-Type natriuretic peptide in porcine coronary arteries. J Cardiovasc Pharmacol. 1998;32:5-11.
22. Miller VM, Lewis DA, Barber DA. Gender differences and endothelium- and platelet-derived factors in the coronary circulation. Clin Exp Pharmacol Physiol. 1999;26:132-136.
23. Woodham C, Birch L, Prins GS. Neonatal estrogen down-regulates prostatic androgen receptor through a proteosome-mediated protein degradation pathway. Endocrinology. 2003;144:4841-4850.
24. Kumar MV, Leo ME, Tindall DJ. Modulation of androgen receptor transcriptional activity by the estrogen receptor. J Androl. 1994;15:534-542.
25. Cardenas H, Pope WF. Attenuation of estrogenic effects by dihydrotestosterone in the pig uterus is associated with downregulation of the estrogen receptors. Biol Reprod. 2004;70:297-302.
26. Chatrath R, Ronningen KL, Severson SR, LaBreche P, Jayachandran M, Bracamonte MP, Miller VM. Endothelium-dependent responses in coronary arteries are changed with puberty in male pigs. Am J Physiol. 2003;285: H1168-H1176.
27. Chambliss KL, Shaul PW. Estrogen modulation of endothelial nitric oxide synthase. Endocrine Reviews. 2002;23:665-686.
28. Hatakeyama H, Nishizawa M, Nakagawa A, Nakano S, Kigoshi T, Uchida K. Testosterone inhibits tumor necrosis factor-α-induced vascular cell adhesion molecule-1expression in human aortic endothelial cells. FEBS Lett. 2002;530: 129-132.
29. Ling S, Dai A, Williams MRI, Myles K, Dilley RJ, Komesaroff PA, Sudhir K. Testosterone (T) enhances apoptosis-related damage in human vascular endothelial cells. Endocrinology. 2002;143:1119-1125.
30. Swinnen JV, Heemers H,Heyns W. Androgen regulation of lipogenesis. Adv Exp Med Biol. 2002;506(Pt. A):379-387.
31. Lopez D, Sanchez MD, Shea-Eaton W, McLean MP. Estrogen activates the high-density lipoprotein receptor gene via binding to estrogen response elements and interaction with sterol regulatory element binding protein-1A. Endocrinology. 2002;143:2155-2168.
32. Machinal-Quelin F, Dieudonne MN, Pecquery R, Leneveu MC, Giudicelli Y. Direct in vitro effects of androgens and estrogens on ob gene expression and leptin secretion in human adipose tissue. Endocrine. 2002;18:179-184.
33. Watanabe T, Akishita M, Nakaoka T, Kozaki K, Miyahara Y, He H, Ohike Y, Ogita T, Inoue S, Muramatsu M, Yamashita N, Ouchi Y. Estrogen receptor β mediates the inhibitory effect of estradiol on vascular smooth muscle cell proliferation. Cardiovasc Res. 2003;59:734-744.
34. Tschugguel W, Dietrich W, Zhegu Z, Stonek F, Kolbus A, Huber JC. Differential regulation of proteasome-dependent estrogen receptor α and β turnover in cultured human uterine artery endothelial cells. J Clin Endocrinol Metab. 2003; 88:2281-2287.
35. Naaz A, Zakroczymski M, Heine P, Taylor J, Saunders P, Lubahn DB, Cooke PS. Effect of ovariectomy on adipose tissue of mice in the absence of estrogen receptor α (ERα): A potential role for estrogen receptor β (ERβ). Hormone and Metabolic Research. 2002;34:758-763.
36. Jayachandran M, Miller VM. Human platelets contain estrogen receptor α, caveolin-1 and estrogen receptor associated proteins. Platelets. 2003;14:75-81.
37. Jayachandran M, Owen WG, Miller VM. Effects of ovariectomy on aggregation, secretion, and metalloproteinases in porcine platelets. Am J Physiol. 2003;284: H1679-H1685.