The mRNA expression of hTERT in human breast carcinomas correlates with VEGF expression

Journal of Carcinogenesis

Volumn 3, Issue , 2004, Pages

  Kirkpatrick, Katharine L ^a   Newbold, Robert F ^b   Mokbel, Kefah ^a,b  

^a ST GEORGE S HOSPITAL   (United Kingdom)

^b BRUNEL UNIVERSITY   (United Kingdom)

Author keywords

Breast; Cancer; hTERT; PCNA; VEGF

Indexed keywords

CYCLINE; MESSENGER RNA; TELOMERASE REVERSE TRANSCRIPTASE; VASCULOTROPIN;

ANALYTIC METHOD; ARTICLE; BREAST CANCER; BREAST CARCINOMA; CANCER TISSUE; CONTROLLED STUDY; CORRELATION ANALYSIS; HUMAN; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; PROGNOSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; STATISTICAL SIGNIFICANCE;

EID: 2942601141     PISSN: 14773163     EISSN: None     Source Type: Journal    
DOI: 10.1186/1477-3163-3-1     Document Type: Article

References (38)

1. Mokbel K: The Role of Telomerase in Breast Cancer. European Journal of Surgical Oncology 2000, 26(5):509-14.
2. Zhu J, Wang H, Bishop J, Blackburn E: Telomerase Extends the Lifespan of Virus-Transformed Human Cells Without Net Telomere Lengthening. Proceedings of the National Academy of Sciences of the United States of America 1999, 96(7):3723-8.
3. Kirkpatrick K, Mokbel K: The Significance of Human Telomerase Reverse Transcriptase in Human Cancer. European Journal of Surgical Oncology 2001, 27:754-60.
4. Liu K, Schoonmaker MM, Levine BL, June CH, Hodes RJ, Weng NP: Constitutive and Regulated Expression of Telomerase Reverse Transcriptase (HTERT) in Human Lymphocytes. Proceedings of the National Academy of Sciences of the United States of America 1999, 96(9):5147-52.
5. Wu A, Ichihashi M, Ueda M: Correlation of the Expression of Human Telomerase Subunits With Telomerase Activity in Normal Skin and Skin Tumors. Cancer 1999, 86(10):2038-44.
6. Kanaya T, Kyo S, Takakura M, Ito H, Namiki M, Inoue M: HTERT Is a Critical Determinant of Telomerase Activity in Renal-Cell Carcinoma. International Journal of Cancer 1998, 78(5):539-43.
7. Bodnar A, Ouellette M, Frolkis M, Holt S, Chiu C, Morin G, Harley C, Shay J, Lichtsteiner S, Wright W: Extension of Life-Span by Introduction of Telomerase into Normal Human Cells. Science 1998, 279:349-52.
8. Kirkpatrick KL, Clark G, Ghilchick M, Newbold RF, Mokbel K: hTERT mRNA expression correlates with telomerose activity in human breast cancer. Eur J Surg Oncol 2003, 29:321-326.
9. Dome JS, Chung S, Bergemann T, Umbricht CB, Saji M, Carey LA, Grundy PE, Perlman EJ, Breslow NE, Sukumar S: High Telomerase Reverse Transcriptase (HTERT) Messenger RNA Level Correlates With Tumor Recurrence in Patients With Favorable Histology Wilms' Tumor. Cancer Research 1999, 59(17):4301-7.
10. Xu D, Gruber A, Peterson C, Pisa P: Telomerase Activity and the Expression of Telomerase Components in Acute Myelogenous Leukaemia. British Journal of Haematology 1998, 102(5):1367-75.
11. Komiya T, Kawase I, Nitta T, Yasumitsu T, Kikui M, Fukuoka M, Nakagawa K, Hirashima T: Prognostic Significance of HTERT Expression in Non-Small Cell Lung Cancer. International Journal of Oncology 2000, 16(6):1173-7.
12. Bieche I, Nogues C, Paradis V, Olivi M, Bedossa P, Lidereau R, Vidaud M: Quantitation of HTERT Gene Expression in Sporadic Breast Tumors With a Real-Time Reverse Transcription-Polymerase Chain Reaction Assay. Clinical Cancer Research 2000, 6(2):452-9.
13. Kirkpatrick KL: The Significantly of Human Telomerase Reverse Transcuptase (hTERT) in Cancer. European Journal of Surgical Oncology 2001, 27:776-83.
14. Kirkpatrick K, Ongunkulade W, Elkak A, Bustin SA, Jenkins P, Ghilchik M, Newbold RF, Mokbel K: HTERT Expression in Human Breast Cancer and Adjacent Non-Cancerous Tissue: Correlation With Tumour Stage and C-Myc Expression. Breast Cancer Res Treat 2003, 77:277-84.
15. Greb R, Wallweiner D, Kiesel L: Vascular Endothelial Growth Factor A (VEGF-A) MRNA Expression Levels Decrease After Menopause in Normal Breast Tissue but Not in Breast Cancer Lesions. British Journal of Cancer 1999, 81(2):225-31.
16. Ruohola J, Valve E, Karkkainen M, Joukov V, Alitalo K, Harkonen P: Vascular Endothelial Growth Factors Are Differentially Regulated by Steroid Hormones and Antiestrogens in Breast Cancer Cells. Molecular and Cellular Endocrinology 1999, 149:29-40.
17. Scott PA, Smith K, Poulsom R, De Benedetti A, Bicknell R, Harris AL: Differential Expression of Vascular Endothelial Growth Factor MRNA Vs Protein Isoform Expression in Human Breast Cancer and Relationship to EIF-4E. British Journal of Cancer 1998, 77(12):2120-8.
18. Brown L, Berse B, Jackman R, Tognazzi K, Guidi A, Dvorak H, Senger D, Connolly J, Schnitt S: Expression of Vascular Permeability Factor (Vascular Endothelial Growth Factor) and Its Receptors in Breast Cancer. Human Pathology 1995, 26:86-91.
19. Toi M, Hoshina T, Takayanagi T, Tominaga T: Association of Vascular Endothelial Growth Factor Expression With Tumor Angiogenesis and With Early Relapse in Primary Breast Cancer. Japanese Journal of Cancer Research 1994, 85:1045-9.
20. Gasparini G: Prognostic Value of Vascular Endothelial Growth Factor in Breast Cancer. Oncologist 2000, 5:Suppl-44.
21. Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, Fiddes JC, Abraham JA: The Human Gene for Vascular Endothelial Growth Factor. Multiple Protein Forms Are Encoded Through Alternative Exon Splicing. Journal of Biological Chemistry 1991, 266(18):11947-54.
22. Robinson C, Stringer S: The Splice Variants of Vascular Endothelial Growth Factor (VEGF) and Their Receptors. Journal of Cell Science 2000, 114:853-65.
23. Cardillo MR, Stamp GW, Pignatelli M: Proliferating Cell Nuclear Antigen in Benign Breast Diseases. European Journal of Gynaecological Oncology 1995, 16(6):476-81.
24. Sheen-Chen S-M, Eng H-L, Chou F-F, Chen W-J: The Prognostic Significance of Proliferating Cell Nuclear Antigen in Patients With Lymph Node-Positive Breast Cancer. Archives of Surgery 1997, 132:264-7.
25. Vidal H, Auboeuf D, DeVos P, Staels B, Riou J, Auwerx J, Laville M: Quantitation of Leptin MRNA in Human Adipose Tissue by RT-Competitive PCR. Qiagen News 1997, 2(1):.
26. Bustin SA, Gyselman VG, Williams NS, Dorudi S: Detection of Cytokeratins 19/20 and Guanylyl Cyclase C in Peripheral Blood of Colorectal Cancer Patients. British Journal of Cancer 1999, 79(11-12):1813-20.
27. Nakanishi K, Hiroi S, Kawai T, Aida S, Kasamatsu H, Aurues T, Ikeda T: Expression of Telomerase Catalytic Subunit (HTERT) MRNA Does Not Predict Survival in Patients With Transitional Cell Carcinoma of the Upper Urinary Tract. Modern Pathology 2001, 14(11):1073-8.
28. Okusa Y, Shinomiya N, Ichikura T, Mochizuki H: Correlation Between Telomerase Activity and DNA Ploidy in Gastric Cancer. Oncology 1998, 55(3):258-64.
29. Herbsleb M, Knudsen U, Orntoft T, Bichel P, Norrild B, Knudsen A, Mogensen O: Telomerase Activity, MIB-1, PCNA, HPV 16 and P53 As Diagnostic Markers for Cervical Intraepithelial Neoplasia. APMIS 2001, 109(9):607-17.
30. Mokbel K, Parris CN, Ghilchik M, Williams G, Newbold RF: The Association Between Telomerase, Histopathological Parameters, and KI-67 Expression in Breast Cancer. American Journal of Surgery 1999, 178(1):69-72.
31. Hiyama E, Gollahon L, Kataoka T, Kuroi K, Yokoyama T, Gazdar AF, Hiyama K, Piatyszek MA, Shay JW: Telomerase Activity in Human Breast Tumors. Journal of the National Cancer Institute 1996, 88(2):116-22.
32. Linderholm B, Lindahl T, Holmberg L, Klaar S, Lennerstrand J, Henriksson R, Bergh J: The Expression of Vascular Endothelial Growth Factor Correlates With Mutant P53 and Poor Prognosis in Human Breast Cancer. Cancer Research 2001, 61:2256-60.
33. Linderholm B, Tavelin B, Grankvist K, Henriksson R: Does Vascular Endothelial Growth Factor (VEGF) Predict Local Relapse and Survival in Radiotherapy-Treated Node-Negative Breast Cancer? British Journal of Cancer 1999, 81(4):727-32.
34. Linderholm B, Lindh B, Tavelin B, Grankvist K, Henriksson R: P53 and Vascular Endothelial Growth Factor (VEGF) Expression Predicts Outcome in 833 Patients With Primary Breast Carcinoma. International Journal of Cancer 2000, 89:51-62.
35. Linderholm B, Tavelin B, Grankvist K, Henriksson R: Vascular Endothelial Growth Factor Is of High Prognostic Value in Node-Negative Breast Carcinoma. Journal of Clinical Oncology 1998, 16:3121-8.
36. Tomii Y, Yamazaki H, Sawa N: Unique Properties of 189 Amino Acid Isoform of Vascular Endothelial Growth Factor in Tumourigenesis. International Journal of Oncology 2002, 21:1251-7.
37. Yuan A, Yu C, Kuo S-H, Chen W-J, Lin F-Y, Luh K-T, Yang P-C, Lee Y-C: Vascular Endothelial Growth Factor 189 MRNA Isoform Expression Specifically Correlates With Tumor Angiogenesis, Patient Survival and Postoperative Relapse in Non-Small Cell Lung Cancer. Journal of Clinical Oncology 2001, 19(2):432-41.
38. Zhang H-T, Scott PA, Morbidelli L, Peak S, Moore J, Turley H, Harris AL, Ziche M, Bicknell R: The 121 Amino Acid Isoform of Vascular Endothelial Growth Factor Is More Strongly Tumorigenic Than Other Splice Variants in Vivo. British Journal of Cancer 2000, 83(1):63-8.