Cleavage-dependent activation of a chlamydia-secreted protease

Molecular Microbiology

Volumn 52, Issue 5, 2004, Pages 1487-1494

  Dong, Feng ^a   Pirbhai, Mustak ^a   Zhong, Youmin ^a   Zhong, Guangming ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLAMYDIAL PROTEASOME LIKE ACTIVITY FACTOR; MUTANT PROTEIN; PROTEINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RFX5; UNCLASSIFIED DRUG;

ARTICLE; CHLAMYDIA; CHLAMYDIASIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME DEGRADATION; ESCHERICHIA COLI; EXPERIMENT; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN SYNTHESIS; TRANSGENE;

AMINO ACID SEQUENCE; ANIMALS; BACTERIAL PROTEINS; CHLAMYDIA; DNA-BINDING PROTEINS; ENDOPEPTIDASES; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENES, MHC CLASS II; HUMANS; MOLECULAR SEQUENCE DATA; OPEN READING FRAMES; SEQUENCE ALIGNMENT; TRANSCRIPTION FACTORS; TRANSGENES;

CHLAMYDIA; ESCHERICHIA COLI; MAMMALIA; NEGIBACTERIA; RICKETTSIALES;

EID: 2942598439     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2004.04072.x     Document Type: Article

References (24)

1. Barry, R., Moore, S., Alonso, A., Ausio, J., and Buckley, J.T. (2001) The channel-forming protein proaerolysin remains a dimer at low concentrations in solution. J Biol Chem 276: 551-554.
2. Boatright, K.M., and Salvesen, G.S. (2003) Caspase activation. Biochem Soc Symp 70: 233-242.
3. Fan, T., Lu, H., Hu, H., Shi, L., McClarty, G.A., Nance, D.M., et al. (1998) Inhibition of apoptosis in chlamydia-infected cells: blockade of mitochondrial cytochrome c release and caspase activation. J Exp Med 187: 487-496.
4. Fan, P., Dong, F., Huang, Y., and Zhong, G. (2002) Chlamydia pneumoniae secretion of a protease-like activity factor for degrading host cell transcription factors required for [correction of factors is required for] major histocompatibility complex antigen expression. Infect Immun 70: 345-349.
5. Gilbert, R.J., Jimenez, J.L., Chen, S., Tickle, I.J., Rossjohn, J., Parker, M., et al. (1999) Two structural transitions in membrane pore formation by pneumolysin, the pore-forming toxin of Streptococcus pneumoniae. Cell 97: 647-655.
6. Hackstadt, T., Fischer, E.R., Scidmore, M.A., Rockey, D.D., and Heinzen, R.A. (1997) Origins and functions of the chlamydial inclusion (see comments). Trends Microbiol 5: 288-293.
7. Heuer, D., Brinkmann, V., Meyer, T.F., and Szczepek, A.J. (2003) Expression and translocation of chlamydial protease during acute and persistent infection of the epithelial HEp-2 cells with Chlamydophila (Chlamydia) pneumoniae. Cell Microbiol 5: 315-322.
8. Maass, M., and Harig, U. (1995) Evaluation of culture conditions used for isolation of Chlamydia pneumoniae. Am J Clin Pathol 103: 141-148.
9. Malghani, M.S., Fang, Y., Cheley, S., Bayley, H., and Yang, J. (1999) Heptameric structures of two alpha-hemolysin mutants imaged with in situ atomic force microscopy. Microsc Res Tech 44: 353-356.
10. Miao, E.A., Brittnacher, M., Haraga, A., Jeng, R.L., Welch, M.D., and Miller, S.I. (2003) Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton. Mol Microbiol 48: 401-415.
11. Patzelt, C., Labrecque, A.D., Duguid, J.R., Carroll, R.J., Keim, P.S., Heinrikson, R.L., et al. (1978) Detection and kinetic behavior of preproinsulin in pancreatic islets. Proc Natl Acad Sci USA 75: 1260-1264.
12. Pirhonen, J., Sareneva, T., Julkunen, I., and Matikainen, S. (2001) Virus infection induces proteolytic processing of IL-18 in human macrophages via caspase-1 and caspase-3 activation. Eur J Immunol 3: 726-733.
13. Read, T.D., Brunham, R.C., Shen, C., Gill, S.R., Heidelberg, J.F., White, O., et al. (2000) Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39. Nucleic Acids Res 28: 1397-1406.
14. Sabet, S.F., Simmons, J., and Caldwell, H.D. (1984) Enhancement of Chlamydia trachomatis infectious progeny by cultivation of HeLa 229 cells treated with DEAE-dextran and cycloheximide. J Clin Microbiol 20: 217-222.
15. Shaw, A.C., Vandahl, B.B., Larsen, M.R., Roepstorff, P., Gevaert, K., Vandekerckhove, J., et al. (2002) Characterization of a secreted Chlamydia protease. Cell Microbiol 4: 411-424.
16. Stein, P.E., Boodhoo, A., Armstrong, G.D., Cockle, S.A., Klein, M.H., and Read, R.J. (1994) The crystal structure of pertussis toxin. Structure 2: 45-57.
17. Stennicke, H.R., and Salvesen, G.S. (2000) Caspases - controlling intracellular signals by protease zymogen activation. Biochim Biophys Acta 1477: 299-306.
18. Stephens, R.S., Kalman, S., Lammel, C., Fan, J., Marathe, R., Aravind, L., et al. (1998) Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis (see comments). Science 282: 754-759.
19. Zhong, G., Toth, I., Reid, R., and Brunham, B.C. (1993) Immunogenicity evaluation of a lipidic amino acid-based synthetic peptide vaccine for Chlamydia trachomatis. J Immunol 151: 3728-3736.
20. Zhong, G., Castellino, F., Romagnoli, P., and Germain, R.N. (1996) Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLIP). J Exp Med 184: 2061-2066.
21. Zhong, G., Reis e Sousa, C., and Germain, R.N. (1997) Production, specificity, and functionality of monoclonal antibodies to specific peptide-major histocompatibility complex class II complexes formed by processing of exogenous protein. Proc Natl Acad Sci USA 94: 13856-13861.
22. Zhong, G., Fan, T., and Liu, L. (1999) Chlamydia inhibits interferon gamma-inducibie major histocompatibility complex class II expression by degradation of upstream stimulatory factor 1. J Exp Med 189: 1931-1938.
23. Zhong, G., Liu, L., Fan, T., Fan, P., and Ji, H. (2000) Degradation of transcription factor RFX5 during the inhibition of both constitutive and interferon gamma-inducible major histocompatibility complex class i expression in Chlamydia-infected cells. J Exp Med 191: 1525-1534.
24. Zhong, G., Fan, P., Ji, H., Dong, F., and Huang, Y. (2001) Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors. J Exp Med 193: 935-942.