Cerivastatin does not prevent oxidative injury of human aortic endothelial cells

Texas Heart Institute Journal

Volumn 31, Issue 2, 2004, Pages 127-131

  Al Ruzzeh, Sharif ^b   Schmidt, Ilona ^b   Nakamura, Koki ^b   Chester, Adrian ^b   Ilsley, Charles ^b   Amrani, Mohamed ^a  

^a HAREFIELD HOSPITAL   (United Kingdom)

^b NONE

Author keywords

Cells, cultured; Cerivastatin; Cycloheximide; Diethylthiocarbamate; Endothelium, vascular; Hydrogen peroxide; Hydroxymethylglutaryl CoA reductase inhibitors pharmacology; Ischemia reperfusion; N acetyl L cysteine; Oxidative stress

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACETYLCYSTEINE; CERIVASTATIN; DIETHYLTHIOCARBAMATE; HYDROGEN PEROXIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; SUPEROXIDE DISMUTASE;

ANTIOXIDANT ACTIVITY; AORTA; ARTICLE; ATHEROGENESIS; CELL CULTURE; CELL DAMAGE; CELL PROTECTION; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; HUMAN; HUMAN CELL; ISCHEMIA; MICROSCOPY; MITOCHONDRION; OXIDATIVE STRESS; REPERFUSION INJURY; VASCULAR ENDOTHELIUM;

AORTA; ENDOTHELIUM; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; OXIDATIVE STRESS; PYRIDINES;

EID: 2942595717     PISSN: 07302347     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Delanty N, Vaughan CJ. Vascular effects of statins in stroke. Stroke 1997;28:2315-20.
2. Vaughan CJ, Delanty N. Neuroprotective properties of statins in cerebral ischemia and stroke. Stroke 1999;30: 1969-73.
3. Laufs U, La Fata V, Plutzky J, Liao JK. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation 1998;97:1129-35.
4. Laufs U, Fata VL, Liao JK. Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase. J Biol Chem 1997;272:31725-9.
5. Weber C, Erl W, Weber KS, Weber PC. HMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemia. J Am Coll Cardiol 1997;30: 1212-7.
6. Negre-Aminou P, van Vliet AK, van Erck M, van Thiel GC, van Leeuwen RE, Cohen LH. Inhibition of proliferation of human smooth muscle cells by various HMG-CoA reductase inhibitors; comparison with other human cell types. Biochim Biophys Acta 1997;1345:259-68.
7. Park YS, Guijarro C, Kim Y, Massy ZA, Kasiske BL, Keane WF, O'Donnell MP. Lovastatin reduces glomerular macrophage influx and expression of monocyte chemoattractant protein-1 mRNA in nephrotic rats. Am J Kidney Dis 1998; 31:190-4.
8. Rauch U, Osende JI, Chesebro JH, Fuster V, Vorchheimer DA, Harris K, et al. Statins and cardiovascular diseases: the multiple effects of lipid-lowering therapy by statins. Atherosclerosis 2000;153:181-9.
9. Fraile ML, Conde MV, Sanz L, Moreno MJ, Marco EJ, Lopez de Pablo AL. Different influence of superoxide anions and hydrogen peroxide on endothelial function of isolated cat cerebral and pulmonary arteries. Gen Pharmacol 1994;25:1197-205.
10. Wagner AH, Kohler T, Ruckschloss U, Just I, Hecker M. Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation. Arterioscler Thromb Vasc Biol 2000;20:61-9.
11. Ballinger SW, Patterson C, Yan CN, Doan R, Burow DL, Young CG, et al. Hydrogen peroxide- and peroxynitrite-induced mitochondrial DNA damage and dysfunction in vascular endothelial and smooth muscle cells. Circ Res 2000; 86:960-6.
12. Liao JK, Shin WS, Lee WY, Clark SL. Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase. J Biol Chem 1995;270:319-24.
13. Ballinger SW, Van Houten B, Jin GF, Conklin CA, Godley BF. Hydrogen peroxide causes significant mitochondrial DNA damage in human RPE cells. Exp Eye Res 1999;68: 765-72.
14. Nordoy A, Bonaa KH, Nilsen H, Berge RK, Hansen JB, Ingebretsen OC. Effects of Simvastatin and omega-3 fatty acids on plasma lipoproteins and lipid peroxidation in patients with combined hyperlipidaemia. J Intern Med 1998; 243:163-70.
15. Endres M, Laufs U, Huang Z, Nakamura T, Huang P, Moskowitz MA, Liao JK. Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc Natl Acad Sci U S A 1998;95:8880-5.
16. Yamada M, Huang Z, Dalkara T, Endres M, Laufs U, Waeber C, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab 2000;20: 709-17.
17. Laufs U, Endres M, Custodis F, Gertz K, Nickenig G, Liao JK, Bohm M. Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription. Circulation 2000;102:3104-10.
18. Palombo C, Lubrano V, Sampietro T. Oxidative stress, F2-isoprostanes and endothelial dysfunction in hypercholesterolemia. Cardiovasc Res 1999;44:474-6.
19. Dobrucki LW, Kalinowski L, Dobrucki IT, Malinski T. Statin-stimulated nitric oxide release from endothelium. Med Sci Monit 2001;7:622-7.
20. Di Napoli P, Maggi A, Spina R, Barsotti L, Taccardi AA, Stuppia L, et al. Simvastatin and ischemia-reperfusion damage: its effects on apoptotic myocyte death and on the endothelial expression of nitric-oxide synthetase in an experimental model of the isolated rat heart [in Italian]. Cardiologia 1999;44:69-74.
21. Bischoff H, Heller AH. Preclinical and clinical pharmacology of cerivastatin. Am J Cardiol 1998;82(4B):18J-25J.
22. Laaksonen R, Jokelainen K, Laakso J, Sahi T, Harkonen M, Tikkanen MJ, Himberg JJ. The effect of simvastatin treatment on natural antioxidants in low-density lipoproteins and high-energy phosphates and ubiquinone in skeletal muscle. Am J Cardiol 1996;77:851-4.