The role of lipidperoxidation in non alcoholic steatohepatitis;A lipidperoxidáció szerepe a nem alkoholos steatohepatitis kialakulásában

Orvosi Hetilap

Volumn 145, Issue 12, 2004, Pages 611-618

  Fraenkel, Emil ^a,d   Lazúrová, Ivica ^c   Fehér, János ^b  

^a Belosztály Ipolyság   (Slovakia)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c P J AFÁRIK UNIVERSITY   (Slovakia)

^d NONE   (Slovakia)

Author keywords

Non alcoholic; Oxidative stress; Steatohepatitis; Steatosis

Indexed keywords

ALCOHOL CONSUMPTION; ARTICLE; DISEASE COURSE; HUMAN; HYPERLIPIDEMIA; JEJUNOILEAL BYPASS; KUPFFER CELL; LIPID PEROXIDATION; LIVER CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; OBESITY; OXIDATIVE STRESS; PARENTERAL NUTRITION; PATHOGENESIS; PREGNANCY; RISK FACTOR; ANIMAL; DIABETES MELLITUS; ENZYME INDUCTION; FAT NECROSIS; FATTY LIVER; FEMALE; HEPATITIS; LIVER MITOCHONDRION; MALE; METABOLISM; PREGNANCY COMPLICATION; REVIEW;

CYTOCHROME P450 2E1;

ANIMALS; CYTOCHROME P-450 CYP2E1; DIABETES COMPLICATIONS; DIABETES MELLITUS; ENZYME INDUCTION; FAT NECROSIS; FATTY LIVER; FEMALE; HEPATITIS; HUMANS; LIPID PEROXIDATION; MALE; MITOCHONDRIA, LIVER; OBESITY; OXIDATIVE STRESS; PREGNANCY; PREGNANCY COMPLICATIONS; RISK FACTORS;

EID: 2942594760     PISSN: 00306002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Angulo, P., Keach, J., Batts, K. és mtsa: Independent predictors of liver fibrosis in patients with non-alcoholic steatohepatitis. Herpetology, 1999, 30, 1356-1362.
2. Bacon, B., Farahvash, M., Janney, C. és mtsa: Nonalcoholic steatohepatitis: an expanded clinical entity. Gastroenterology, 1994, 107, 1103-1111.
3. Bergman, R. N., Ader, M.: Free fatty acids and pathogenesis of type 2 diabetes mellitus. Trends Endocr. Metab., 2000, 11, 351-356.
4. Bignamini, A. A.: Metadoxil. Alcoholic liver disease, a new multifactorial therapeutic approach. Eurodrug Laboratories. The Hague, 1998.
5. Blázovics, A., Abaza, M., Sípos, P. és mtsa: Biochemical and morphological changes in liver and gallbladder bile of broiler chicken exposed to heavy metals (cadmium, lead, mercury). Trace Elements and Electrolytes, 2001, 18, 4.
6. Blázovics, A., Lugasi, T., Kemény, K. és mtsa: Membrane stabilizing effects of natural polyphenols and flavonoids from S. Tectorum on hepatic microsomal P450 system in hyperlipidemic rats. J. Ethnopharmacology, 2000, 73, 479-485.
7. Bonkovsky, H., Jawaid, Q., Tortorelli, K. és mtsa: Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis. J. Hepatol., 1999, 31, 421-429.
8. Brunt, E. M., Janney, C. G., Di Bisceglie, A. M. és mtsai: Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am. J. Gastroenterol, 1999, 94, 2467-2474.
9. Caballeria, J., Pares, A., Brú, C. és mtsai: Metadoxin accelerates fatty liver recovery in alcoholic patients: results of randomized, double blind, placebo control trial. J. Hepatol., 1998, 28, 54-60.
10. Caldwell, S., Oelsner, D., Iezzoni, D. és mtsai: Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease. Hepatology, 1999, 29, 664-669.
11. Caldwell, S. H., Swerdlow, R. H., Khan, E. M. és mtsai: Mitochondrial abnormalities in nonalcoholic steatohepatitis. J. Hepatol., 1999, 31, 430-434.
12. Cheeseman, K. H.: Lipid peroxidation and cancer. In B. Haliwell, O.I. Aruoma (eas.): DNA and free radicals. Ellis Horwood, New-York, London, 1993, 109-144. old.
13. Chojkier, M., Houglum, K., Solis Herruzo, J. és mtsa: Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. A role for lipid peroxidation? J. Biol. Chem., 1989, 264, 16957-16962.
14. Cortez-Pinto, H., Baptista, A., Camilo, M. és mtsa: Nonalcoholic steatohepatitis. Clinicopathological comparison with alcoholic hepatitis in ambulatory and hospitalized patients. Dig. Dis. Sci., 1996, 41, 172-179.
15. Cortez Pinto, H., Chatham, J., Chacko, V. és mtsai: Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis- a pilot study. JAMA, 1999, 282, 1659-1664.
16. Diehl, A., Goodman, Z., Ishak, K.: Alcohol like liver disease in non-alcoholics. A clinical and histologic comparison with alcohol induced liver injury. Gastroenterology, 1988, 95, 1056-1062.
17. Dixon, J., Bhathal, S. O., Brien, P.: Nonalcoholic fatty liver disease: Predictors of Nonalcoholic Steatohepatitis and Liver fibrosis in the severely obese. Gastroenterology, 2001, 121, 91-100.
18. Drenick, E., Fisler, J., Johnson, D.: Hepatic steatosis after intestinal bypass-prevention and reversal by metronidazoie irrespective of protein caloric malnutrition. Gastroenterology, 1982, 82, 535-548.
19. Esterbauer, R., Schaur, R. J., Zollner, H.: Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Rad. Biol. Med., 1991, 11, 81-128.
20. Fantone, J. C., Ward, P. A.: Role of oxygen derived free radicals and metabolites in leukocyte-dependent inflammatory reactions. Am. J. Pathol., 1982, 107, 397-418.
21. Fehér, J., Lengyel, G., Blázovics, A.: Oxidative stress in liver and biliary tract diseases. Scand. J. Gastroenterol., 1988, 228 (Suppl), 38-48.
22. Fehér, J., Lengyel, G.: A New Approach to Drug Therapy in Non-alcoholic Steatohepatitis (NASH). J. Int. Med. Res., 2003, 31, 537-551.
23. Fehér, J., Romics, L., Jakab, L. és mtsa: Serum lipids and lipoproteins in chronic liver disease. Acta Med. Acad. Sci. Hung., 1976, 33, 217-223.
24. Fenton, H. J. H.: Oxidation of certain organic acids in the presence of ferrous salts. Proc. Chem. Soc., 1999, 15, 224-228.
25. Fong, D., Nehra, V., Lindor, K. és mtsa: Buchman A. Metabolic and nutritional considerations in nonalcoholic fatty liver. Hepatology, 2000, 32, 3-10.
26. Friedman, S. L.: The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N. Eng. J. Med., 1993, 328, 1828-1835.
27. Friedman, J. M.: Leptin, leptin receptors, and the control of body weight. Nutrition Rev., 1997, 56, S38-S46.
28. George, D., Goldwurm, S., MacDonald, G. és mtsai: Incresed hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis. Gastroenterology, 1998, 114, 311-318.
29. Itoh, S., Yougel, T., Kawagoe, K.: Comparison between nonalcoholic steatohepatitis and alcoholic hepatitis. Am. J. Gastroenterol, 1987, 82, 650-654.
30. James, O., Day, C.: Steatohepatitis: a tale of two hits? Gastroenterology, 1998, 114, 842-845.
31. Kappus, H.: Overview of enzyme systems involved in bioreduction of drugs in redox cycling. Biochem. Pharmacol., 1986, 35, 1-6.
32. Jonsson, J. R., Clouston, D. A., Ando, Y. és mtsa: Angiotensin-Converting Enzyme Inhibition Attenuates the progression of rat hepatic fibrosis. Gastroenterology, 2001, 121, 148-155.
33. Leclercq, I. A., Farell, G. C., Field, J. és mtsa: CYP 2E1 and CYP 4A as microsomal catalysts of lipid peroxides in murine non-alcoholic steatohepatitis. J. Clin. Invest., 2000, 105, 1067-1075.
34. Lieber, C. S., De Carli, L. M.: Hepatic microsomal ethanol oxidizing system. In vitro characteristics and adaptive properties in vivo. J. Biol. Chem., 1970, 245, 2505-2512.
35. Ludwig, J., Viggiano, T., McGill, D. és mtsa: Nonalcoholic steatohepatitis. Mayo clinic experiences with a hitherto unnamed disease. Mayo Clin. Proc., 1980, 55, 434-438.
36. McCord, J. M.: Oxygen derived free radicals in postischemic tissue injury. N. Engl. J. Med., 1985, 312, 159-163.
37. Mezey, E.: Fatty liver. In Schiffs diseases of the liver. 8th ed. Szerk.: Schiff, E., Sorell, M., Maddrey, W. Lippincott Raven, Philadelphia, PA. 1999, 1185-1197. old.
38. Nonomura, A., Mizukami, Y., Unoura, M. és mtsai: Clinicopathologic study of alcohol-like liver disease in non-alcoholics, non-alcoholic steatohepatitis and fibrosis. Gastroenterol. Jpn., 1992, 27, 521-528.
39. Orrenius, S., McConkey, D. J., Bellomo, G. és mtsa: Role of calcium in toxic cell killing. Trends Pharmacol. Sci., 1989, 10, 281-285.
40. Orrenius, S., Nicotera, P.: Biochemical mechanisms of oxidative liver cell injury. Bull. Eur. Physiopathol. Respir., 1987, 23, 291-295.
41. Perez-Carreera, M., Del Hoyo, P., Ma, M. és mtsai: Activity of the mitochondrial respiratory chain enzymes is decreased in the liver of patients with nonalcoholic steatohepatitis (abstr.). Hepatology, 1999, 30, 873.
42. Pietrangelo, A., Gualdi, R., Casalgrandi, G. és mtsai: Enhanced hepatic collagen typ I mRNA expression into fat-storing cells in a rodent model of hemochromatosis. Hepatology, 1994, 19, 714-721.
43. Schmidt, J., Diehl, A.: Cytokines and alcoholic liver disease. Semin. Liver Dis., 1993, 13, 170-182.
44. Potter, J., Womack, L., Mezey, E. és mtsa: Transdifferentiation of rat hepatic stellate cells results in leptin expression. Biochem. Biophys. Res. Commun., 1998, 244, 178-182.
45. Samsheer, K. S., Farell, D., Campbell, S. és mtsai: Clinicopathological features and predictors of fibrosis in non alcoholic fatty liver disease (NAFLD) patients in the south west of England. J. Hepatol., 2003, 38 (Suppl 2), A 4177.
46. Sanyal, A. J., Campbell-Sargent, C., Mirshahi, F. és mtsa: Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology, 2001, 120, 1183-1192.
47. Stega, T. E.: Acetaldehyde-induced lipid peroxidation in isolated hepatocytes. Res. Commun. Chem. Pathol. Pharmacol, 1982, 36, 287-292.
48. Reid, E.: Nonalcoholic steatohepatitis. Gastroenterology, 2001, 121, 710-723.
49. Ursini, F., Maiorino, M., Sevanian, A.: Membrane hydroperoxides. In Szerk.: Sies, H. Oxidative stress. Oxidants and antioxidants. Academic Press, London, 1991, 319-336. old.
50. Wanless, I., Lentz, J.: Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology, 1990, 12, 1106-1110.
51. Weltman, M. D., Farell, G. C., Hall, P. és mtsai: Hepatic cytochrome P450 2E1 is increased in patients with non-alcoholic steatohepatitis. Hepatology, 1998, 27, 128-133.
52. Zhang, C. Y., Baffy, G., Perret, P. és mtsai: Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, b-cell dysfunction and type 2 diabetes. Cell, 2001, 105, 745-755.