-
1
-
-
0027755282
-
Phosphorylation of the enantiomers of the carbocyclic analog of 2′-deoxyguanosine in cells infected with herpes simplex virus type 1 and in uninfected cells. Lack of enantiomeric selectivity with the viral thymidine kinase
-
Bennett L.L., Parker W.B., Allan P.W., Rose L.M., Shealy Y.F., Secrist J.A. III, Montgomery J.A., Arnett G., Kirkman R.L., Shannon W.M. Phosphorylation of the enantiomers of the carbocyclic analog of 2′-deoxyguanosine in cells infected with herpes simplex virus type 1 and in uninfected cells. Lack of enantiomeric selectivity with the viral thymidine kinase. Mol. Pharmacol. 44:1993;1258-1266
-
(1993)
Mol. Pharmacol.
, vol.44
, pp. 1258-1266
-
-
Bennett, L.L.1
Parker, W.B.2
Allan, P.W.3
Rose, L.M.4
Shealy, Y.F.5
Secrist III, J.A.6
Montgomery, J.A.7
Arnett, G.8
Kirkman, R.L.9
Shannon, W.M.10
-
2
-
-
0020446478
-
Molecular mechanics simulation of protein-ligand interactions: Binding of thyroid hormone analogs to prealbumin
-
Blaney J.M., Weiner P.K., Dearing A., Kollman P.A., Jorgensen E.C., Oatley S.J., Burridge J.M., Blake C.C.F. Molecular mechanics simulation of protein-ligand interactions: binding of thyroid hormone analogs to prealbumin. J. Am. Chem. Soc. 104:1982;6424-6434
-
(1982)
J. Am. Chem. Soc.
, vol.104
, pp. 6424-6434
-
-
Blaney, J.M.1
Weiner, P.K.2
Dearing, A.3
Kollman, P.A.4
Jorgensen, E.C.5
Oatley, S.J.6
Burridge, J.M.7
Blake, C.C.F.8
-
3
-
-
0036888780
-
Understanding the unique mechanism of L-FMAU (Clevudine) against hepatitis B virus: Molecular dynamics studies
-
Chong Y., Chu C.K. Understanding the unique mechanism of L-FMAU (Clevudine) against hepatitis B virus: molecular dynamics studies. Bioorg. Med. Chem. Lett. 12:2002;3459-3462
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, pp. 3459-3462
-
-
Chong, Y.1
Chu, C.K.2
-
4
-
-
0038240528
-
Molecular mechanism of DAPD/DXG against zidovudine- and lamivudine-drug resistant mutants: A molecular modelling approach
-
Chong Y., Borroto-Esoda K., Furman P.A., Schinazi R.F., Chu C.K. Molecular mechanism of DAPD/DXG against zidovudine- and lamivudine-drug resistant mutants: a molecular modelling approach. Antivir. Chem. Chemother. 13:2002a;115-128
-
(2002)
Antivir. Chem. Chemother.
, vol.13
, pp. 115-128
-
-
Chong, Y.1
Borroto-Esoda, K.2
Furman, P.A.3
Schinazi, R.F.4
Chu, C.K.5
-
5
-
-
0037168035
-
Stereoselective synthesis and antiviral activity of D-2′,3′- didehydro-2′,3′-dideoxy-2′-fluoro-4′-thionucleosides
-
Chong Y., Choo H., Choi Y., Matthew J., Schinazi R.F., Chu C.K. Stereoselective synthesis and antiviral activity of D-2′, 3′-didehydro-2′, 3′-dideoxy-2′-fluoro-4′- thionucleosides. J. Med. Chem. 45:2002b;4888-4898
-
(2002)
J. Med. Chem.
, vol.45
, pp. 4888-4898
-
-
Chong, Y.1
Choo, H.2
Choi, Y.3
Matthew, J.4
Schinazi, R.F.5
Chu, C.K.6
-
6
-
-
2942611906
-
-
abstr. 611.
-
Chong, Y., Schinazi, R.F., Chu, C.K., 2003. Abstr. 10th CROI, abstr. 611.
-
(2003)
Abstr. 10th CROI
-
-
Chong, Y.1
Schinazi, R.F.2
Chu, C.K.3
-
7
-
-
0026541703
-
The separated enantiomers of 2′-deoxy-3′-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro
-
Coates J.A.V., Cammack N., Jenkinson H.J., Mutton I.M., Pearson B.A., Storer R., Cameron J.M., Penn C.R. The separated enantiomers of 2′-deoxy-3′-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro. Antimicrob. Agents Chemother. 36:1992;202-205
-
(1992)
Antimicrob. Agents Chemother.
, vol.36
, pp. 202-205
-
-
Coates, J.A.V.1
Cammack, N.2
Jenkinson, H.J.3
Mutton, I.M.4
Pearson, B.A.5
Storer, R.6
Cameron, J.M.7
Penn, C.R.8
-
8
-
-
0029011701
-
A second generation force field for the simulation of proteins, nucleic acids, and organic molecules
-
Cornell W.D., Cieplak P., Bayly C.I., Gould I.R., Merz K.M. Jr., Ferguson D.M., Spellmeyer D.C., Fox T., Caldwell J.W., Kollman P.A. A second generation force field for the simulation of proteins, nucleic acids, and organic molecules. J. Am. Chem. Soc. 117:1995;5179-5197
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 5179-5197
-
-
Cornell, W.D.1
Cieplak, P.2
Bayly, C.I.3
Gould, I.R.4
Merz Jr., K.M.5
Ferguson, D.M.6
Spellmeyer, D.C.7
Fox, T.8
Caldwell, J.W.9
Kollman, P.A.10
-
9
-
-
0030937244
-
Organic fluorine hardly ever accepts hydrogen bonds
-
Dunitz J.D., Taylor R. Organic fluorine hardly ever accepts hydrogen bonds. Chem. Eur. J. 3:1997;89-98
-
(1997)
Chem. Eur. J.
, vol.3
, pp. 89-98
-
-
Dunitz, J.D.1
Taylor, R.2
-
10
-
-
0029094279
-
Stereospecificity of human DNA-polymerases-α, -β, -γ, -δ And -ε, HIV-reverse transcriptase, HSV-1 DNA-polymerase, calf thymus terminal transferase and Escherichia coli DNA-polymerase 1 in recognizing D- and L-thymidine 5′-triphosphate as substrate
-
Focher F., Maga G., Bendiscioli A., Capobianco M., Colonna F., Garbesi A., Spadari S. Stereospecificity of human DNA-polymerases-α, -β, -γ, -δ and -ε, HIV-reverse transcriptase, HSV-1 DNA-polymerase, calf thymus terminal transferase and Escherichia coli DNA-polymerase 1 in recognizing D- and L-thymidine 5′-triphosphate as substrate. Nucleic Acids Res. 23:1995;2840-2847
-
(1995)
Nucleic Acids Res.
, vol.23
, pp. 2840-2847
-
-
Focher, F.1
Maga, G.2
Bendiscioli, A.3
Capobianco, M.4
Colonna, F.5
Garbesi, A.6
Spadari, S.7
-
11
-
-
0032951562
-
Sensitivity of L-(-)2′,3′-dideoxythiacytidine resistant hepatitis B virus to other antiviral nucleoside analogues
-
Fu L., Liu S.-H., Cheng Y.-C. Sensitivity of L-(-)2′, 3′-dideoxythiacytidine resistant hepatitis B virus to other antiviral nucleoside analogues. Biochem. Pharmacol. 57:1999;1351-1359
-
(1999)
Biochem. Pharmacol.
, vol.57
, pp. 1351-1359
-
-
Fu, L.1
Liu, S.-H.2
Cheng, Y.-C.3
-
12
-
-
0026469165
-
The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1, 3-oxathiolan-5-yl] cytosine
-
Furman P.A., Davis M., Liotta D.C., Paff M., Frick L.W., Nelson D.J., Dornsife R.E., Wurster J.A., Wilson L.J., Fyfe J.A., Tuttle J.V., Miller W.H., Condreay L., Averett D.R., Schinazi R.F., Painter G.R. The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1, 3-oxathiolan-5-yl] cytosine. Antimicrob. Agents Chemother. 36:1992;2686-2692
-
(1992)
Antimicrob. Agents Chemother.
, vol.36
, pp. 2686-2692
-
-
Furman, P.A.1
Davis, M.2
Liotta, D.C.3
Paff, M.4
Frick, L.W.5
Nelson, D.J.6
Dornsife, R.E.7
Wurster, J.A.8
Wilson, L.J.9
Fyfe, J.A.10
Tuttle, J.V.11
Miller, W.H.12
Condreay, L.13
Averett, D.R.14
Schinazi, R.F.15
Painter, G.R.16
-
13
-
-
0035162759
-
Mechanism of action of 1-β-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-β-D-dioxolane guanosine
-
Furman P.A., Jeffrey J., Keifer L.L., Feng J.Y., Anderson J.S., Borroto-Esoda K., Hill E., Copeland W.C., Chu C.K., Sommadossi J.P., Liberman I., Schinazi R.F., Painter G.R. Mechanism of action of 1-β-D-2, 6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-β-D-dioxolane guanosine. Antimicrob. Agents Chemother. 45:2001;158-165
-
(2001)
Antimicrob. Agents Chemother.
, vol.45
, pp. 158-165
-
-
Furman, P.A.1
Jeffrey, J.2
Keifer, L.L.3
Feng, J.Y.4
Anderson, J.S.5
Borroto-Esoda, K.6
Hill, E.7
Copeland, W.C.8
Chu, C.K.9
Sommadossi, J.P.10
Liberman, I.11
Schinazi, R.F.12
Painter, G.R.13
-
14
-
-
0028877076
-
The effect of absolute configuration on the anti-HIV and anti-HBV activity of nucleoside analogues
-
Furman P.A., Wilson J.E., Reardon J.E., Painter G.R. The effect of absolute configuration on the anti-HIV and anti-HBV activity of nucleoside analogues. Antivir. Chem. Chemother. 6:1995;345-355
-
(1995)
Antivir. Chem. Chemother.
, vol.6
, pp. 345-355
-
-
Furman, P.A.1
Wilson, J.E.2
Reardon, J.E.3
Painter, G.R.4
-
15
-
-
49149147973
-
Iterative partial equalization of orbital electronegativity - A rapid access to atomic charges
-
Gästeiger J., Marsili M. Iterative partial equalization of orbital electronegativity - a rapid access to atomic charges. Tetrahedron. 36:1980;3219-3228
-
(1980)
Tetrahedron
, vol.36
, pp. 3219-3228
-
-
Gästeiger, J.1
Marsili, M.2
-
16
-
-
0032823357
-
Mechanism of action and in vitro activity of 1′,3′- dioxolanylpurine nucleoside analogues against sensitive and drug-resistant human immunodeficiency virus type 1 variants
-
Gu Z., Wainberg M.A., Nguyen-Ba N., L'Heureux L., De Muys J.M., Bowlin T.L., Rando R.F. Mechanism of action and in vitro activity of 1′, 3′-dioxolanylpurine nucleoside analogues against sensitive and drug-resistant human immunodeficiency virus type 1 variants. Antimicrob. Agents Chemother. 43:1999;2376-2382
-
(1999)
Antimicrob. Agents Chemother.
, vol.43
, pp. 2376-2382
-
-
Gu, Z.1
Wainberg, M.A.2
Nguyen-Ba, N.3
L'Heureux, L.4
De Muys, J.M.5
Bowlin, T.L.6
Rando, R.F.7
-
17
-
-
0032573488
-
Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: Implications for drug resistance
-
Huang H., Chopra R., Verdine G.L., Harrison S.C. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance. Science. 282:1998;1669-1675
-
(1998)
Science
, vol.282
, pp. 1669-1675
-
-
Huang, H.1
Chopra, R.2
Verdine, G.L.3
Harrison, S.C.4
-
18
-
-
0028841320
-
Genotypic and phenotypic characterization of HIV-1 isolated from patients receiving (-)-2′,3′-dideoxy-3′-thiacytidine
-
Kavlick M.F., Shirasaka T., Kojima E., Pluda J.M., Hui F. Jr., Yarchoan R., Mitsuya H. Genotypic and phenotypic characterization of HIV-1 isolated from patients receiving (-)-2′, 3′-dideoxy-3′-thiacytidine. Antivir. Res. 28:1995;133-146
-
(1995)
Antivir. Res.
, vol.28
, pp. 133-146
-
-
Kavlick, M.F.1
Shirasaka, T.2
Kojima, E.3
Pluda, J.M.4
Hui Jr., F.5
Yarchoan, R.6
Mitsuya, H.7
-
19
-
-
0026734306
-
Asymmetric synthesis of 1,3-dioxolane pyrimidine nucleosides and their anti-HIV activity
-
Kim H.O., Ahn S.K., Alves A.J., Beach J.W., Jeong L.S., Choi B.G., Van Roey P., Schinazi R.F., Chu C.K. Asymmetric synthesis of 1, 3-dioxolane pyrimidine nucleosides and their anti-HIV activity. J. Med. Chem. 35:1992;1987-1995
-
(1992)
J. Med. Chem.
, vol.35
, pp. 1987-1995
-
-
Kim, H.O.1
Ahn, S.K.2
Alves, A.J.3
Beach, J.W.4
Jeong, L.S.5
Choi, B.G.6
Van Roey, P.7
Schinazi, R.F.8
Chu, C.K.9
-
20
-
-
0029028067
-
Potential mechanisim for sustained antiretroviral efficacy of AZT-3TC combination therapy
-
Larder B.A., Kemp S.D., Harrigan P.R. Potential mechanisim for sustained antiretroviral efficacy of AZT-3TC combination therapy. Science. 269:1995;696-699
-
(1995)
Science
, vol.269
, pp. 696-699
-
-
Larder, B.A.1
Kemp, S.D.2
Harrigan, P.R.3
-
21
-
-
0035173806
-
Molecular modeling approach to understanding the mode of action of L-nucleosides as antiviral agents
-
Lee K., Chu C.K. Molecular modeling approach to understanding the mode of action of L-nucleosides as antiviral agents. Antimicrob. Agents Chemother. 45:2001;138-144
-
(2001)
Antimicrob. Agents Chemother.
, vol.45
, pp. 138-144
-
-
Lee, K.1
Chu, C.K.2
-
22
-
-
33751578897
-
A brief review and table of semiempirical parameters used in the Hückel molecular orbital method
-
Purcell W.P., Singer J.A. A brief review and table of semiempirical parameters used in the Hückel molecular orbital method. J. Chem. Eng. Data. 12:1967;235-246
-
(1967)
J. Chem. Eng. Data
, vol.12
, pp. 235-246
-
-
Purcell, W.P.1
Singer, J.A.2
-
23
-
-
0029036828
-
5-Iodo-2′-deoxy-L-uridine and (E)-5-(2-bromovinyl)-2′-deoxy- L-uridine: Selective phosphorylation by herpes-simplex virus type 1 thymidine kinase, antiherpetic activity, and cytotoxicity studies
-
Spadari S., Ciarrocchi G., Focher F., Verri A., Maga G., Arcamone F., Iafrate E., Manzini S., Garbesi A., Tondelli L. 5-Iodo-2′-deoxy-L-uridine and (E)-5-(2-bromovinyl)-2′-deoxy-L-uridine: selective phosphorylation by herpes-simplex virus type 1 thymidine kinase, antiherpetic activity, and cytotoxicity studies. Mol. Pharmacol. 47:1995;1231-1238
-
(1995)
Mol. Pharmacol.
, vol.47
, pp. 1231-1238
-
-
Spadari, S.1
Ciarrocchi, G.2
Focher, F.3
Verri, A.4
Maga, G.5
Arcamone, F.6
Iafrate, E.7
Manzini, S.8
Garbesi, A.9
Tondelli, L.10
-
24
-
-
0027285372
-
Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase
-
Tisdale M., Kemp S.D., Parry N.R., Larder B.A. Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase. Proc. Natl. Acad. Sci. U.S.A. 90:1993;5653-5656
-
(1993)
Proc. Natl. Acad. Sci. U.S.A.
, vol.90
, pp. 5653-5656
-
-
Tisdale, M.1
Kemp, S.D.2
Parry, N.R.3
Larder, B.A.4
-
25
-
-
0026491206
-
β-L-Thymidine 5′-triphosphate analogs as DNA polymerase substrates
-
Van Draanen N.A., Tucker S.C., Boyd F.L., Trotter B.W., Reardon J.E. β-L-Thymidine 5′-triphosphate analogs as DNA polymerase substrates. J. Biol. Chem. 267:1992;25019-25024
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 25019-25024
-
-
Van Draanen, N.A.1
Tucker, S.C.2
Boyd, F.L.3
Trotter, B.W.4
Reardon, J.E.5
-
26
-
-
84988053694
-
An all atom force-field for simulations of proteins and nucleic-acids
-
Weiner S.J., Kollman P.A., Nguyen D.T., Case D.A. An all atom force-field for simulations of proteins and nucleic-acids. J. Comp. Chem. 7:1986;230-252
-
(1986)
J. Comp. Chem.
, vol.7
, pp. 230-252
-
-
Weiner, S.J.1
Kollman, P.A.2
Nguyen, D.T.3
Case, D.A.4
-
27
-
-
0001154313
-
Molecular mechanics studies of enzyme-substrate interactions: The interaction of L- and D-N-acetyltryptophanamide with α-chymotrypsin
-
Wipff G., Dearing A., Weiner P.K., Blaney J.M., Kollman P.A. Molecular mechanics studies of enzyme-substrate interactions: the interaction of L- and D-N-acetyltryptophanamide with α-chymotrypsin. J. Am. Chem. Soc. 105:1983;997-1005
-
(1983)
J. Am. Chem. Soc.
, vol.105
, pp. 997-1005
-
-
Wipff, G.1
Dearing, A.2
Weiner, P.K.3
Blaney, J.M.4
Kollman, P.A.5
-
28
-
-
0028207542
-
Chiral discrimination of enantiomeric 2′-deoxythymidine 5′-triphosphate by HIV-1 reverse transcriptase and eukaryotic DNA polymerases. Synthetic nucleosides and nucleotides
-
Yamaguchi T., Iwanami N., Shudo K., Saneyoshi M. Chiral discrimination of enantiomeric 2′-deoxythymidine 5′-triphosphate by HIV-1 reverse transcriptase and eukaryotic DNA polymerases. Synthetic nucleosides and nucleotides. Biochem. Biophys. Res. Commun. 200:1994;1023-1027
-
(1994)
Biochem. Biophys. Res. Commun.
, vol.200
, pp. 1023-1027
-
-
Yamaguchi, T.1
Iwanami, N.2
Shudo, K.3
Saneyoshi, M.4
|