Alternative splicing of mammalian Intersectin 1: Domain associations and tissue specificities

Genomics

Volumn 84, Issue 1, 2004, Pages 106-113

  Tsyba, Lyudmyla ^a   Skrypkina, Inessa ^a   Rynditch, Alla ^a   Nikolaienko, Oleksii ^a   Ferenets, Ganna ^a   Fortna, Andrew ^b   Gardiner, Katheleen ^b  

^a INSTITUTE OF MOLECULAR BIOLOGY AND GENETICS   (Ukraine)

^b UNIVERSITY OF DENVER   (United States)

Author keywords

Alternative splicing; Brain specific splicing; Intersectin 1; SH3 domain; Transcriptional isoforms

Indexed keywords

INTERSECTIN; INTERSECTIN 1; ISOPROTEIN; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FETUS; GENETIC CONSERVATION; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN VARIANT; TISSUE SPECIFICITY;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ALTERNATIVE SPLICING; ANIMALS; BASE SEQUENCE; CLATHRIN; ENDOCYTOSIS; EXONS; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MOLECULAR SEQUENCE DATA; ORGAN SPECIFICITY; PROTEIN ISOFORMS; RATS;

MAMMALIA;

EID: 2942588871     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ygeno.2004.02.005     Document Type: Article

References (25)

1. McPherson P.S., Kay B.K., Hussain N.K. Signaling on the endocytic pathway. Traffic. 2:2001;375-384
2. Hussain N.K., et al. Splice variants of Intersectin are components of the endocytic machinery in neurons and nonneuronal cells. J. Biol. Chem. 274:1999;15671-15677
3. Guipponi M., et al. Two isoforms of a human intersectin (ITSN) protein are produced by brain-specific alternative splicing in a stop codon. Genomics. 53:1998;369-376
4. Adams A., Thorn J.M., Yamabhai M., Kay B.K., O'Bryan J.P. Intersectin, an adaptor protein involved in clathrin mediated endocytosis, activates mitogenic signaling pathways. J. Biol. Chem. 275:2000;27414-27420
5. Hussain N., et al. Endocytic protein Intersectin-1 regulates actin assembly via Cdc42 and N-WASP. Nat. Cell Biol. 3:2001;927-932
6. Jenna S., et al. The activity of the GTPase-activating protein CdGAP is regulated by the endocytic protein Intersectin. J. Biol. Chem. 277:2002;6366-6372
7. Tong X.-K., et al. The endocytic protein Intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain. EMBO J. 19:2000;1263-1271
8. Tong X.-K., Hussain N.K., Adams A.G., O'Bryan J.P., McPherson P.S. Intersectin can regulate the Ras/MAP kinase pathway independent of its role in endocytosis. J. Biol. Chem. 275:2000;29892-29899
9. Okamoto M., Schoch S., Sudhoff T.C. EHSH1/Intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. J. Biol. Chem. 274:1999;18446-18454
10. Yamabhai M., et al. Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains. J. Biol. Chem. 273:1998;31401-31407
11. Sengar A.S., Want W., Bishay J., Cohen S., Egan S.E. The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15. EMBO J. 18:1999;1159-1171
12. Snyder J.T., et al. Quantitative analysis of the effect of phosphoinositide interactions on the function of Db1 family proteins. J. Biol. Chem. 276:2001;45868-45875
13. Pucharcos C., Casas C., Nadal M., Estivill X., de la Luna S. The human intersectin genes and their splice variants are differentially expressed. Biochim. Biophys. Acta. 1521:2001;1-11
14. Altschul S.F., et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25:1997;3389-3402
15. Pennisi E. Human genome: a low number wins the GeneSweep Pool. Science. 300:2003;1484
16. Modrek B., Lee C. A genomic view of alternative splicing. Nat. Genet. 30:2002;13-19
17. Martina J.A., Bonangelino C.J., Aguilar R.C., Bonifacino J.S. Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery. J. Cell Biol. 153:2001;1111-1120
18. Martinez R., Mathey-Prevot B., Bernards A., Baltimore D. Neuronal pp60c-src contains a six-amino acid insertion relative to its non-neuronal counterpart. Science. 237:1987;411-415
19. Noble M.E.M., Musacchio A., Saraste M., Courtneidge S.A., Wierenga R.K. Crystal structure of the SH3 domain in human Fyn: comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin. EMBO J. 12:1993;2617-2624
20. Lim W.A., Richards F.M., Fox R.O. Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains. Nature. 372:1994;375-379
21. Owen D.J., et al. Crystal structure of the amphiphysin-2 SH3 domain and its role in the prevention of dynamin ring formation. EMBO J. 17:1998;5273-5285
22. Simpson F., et al. SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation. Nat. Cell Biol. 1:1999;119-124
23. Wagner E., Lykke-Andersen J. mRNA surveillance: the perfect persist. J. Cell Sci. 115:2002;3033-3038
24. Danckwardt S., et al. Abnormally spliced β-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decay. Blood. 99:2002;1811-1816
25. Yu H., et al. Solution structure of the SH3 domain of Src and identification of its ligand-binding site. Science. 258:1992;1665-1668