A preferred synthesis of 1,2,4-oxadiazoles

Synthetic Communications

Volumn 34, Issue 10, 2004, Pages 1863-1870

  Pipik, Brenda ^a   Ho, Guo Jie ^a   Williams, J Michael ^a   Conlon, David A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

1,2,4 Oxadiazoles; Carboxylic acids; High yielding synthesis; Hydroxybenzotriazole

Indexed keywords

1,2,4 OXADIAZOLE DERIVATIVE; CARBOXYLIC ACID; OXIME; TRIAZOLE DERIVATIVE;

ARTICLE; CRYSTALLIZATION; CYCLIZATION; HYDROLYSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REPRODUCIBILITY; STEREOCHEMISTRY; SYNTHESIS;

EID: 2942558843     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1081/SCC-120034169     Document Type: Article

References (9)

1. Deschenes, D.; Dube, D.; Gallant, M.; Girard, Y.; Lacombe, P.; Macdonald, D.; Mastracchio, A.; Perrier, H. Substituted 8-Arylquinoline Phosphodiesterase-4 Inhibitors. International Patent WO2002060897, June 28, 2001.
2. Deegan, T.L.; Nitz, T.J.; Cebzanov, D.; Pufko, D.E.; Porco, J.A. Bioorg. Med. Chem. Lett. 1999, 9, 209-212.
3. Liang, G.-B.; Feng, D.D. Tetrahedron Lett. 1996, 37, 6627-6630.
4. Diana, G.D.; Volkots, D.L.; Hitz, T.J.; Bailey, T.R.; Long, M.A.; Vescio, N.; Aldous, S.; Pevear, D.C.; Dutko, F.J. J. Med. Chem. 1994, 37, 2421-2436.
5. Borg, S.; Estenne-Bouhtou, G.; Luthman, K.; Csoregh, I.; Hesselink, W.; Hacksell, U. J. Org. Chem. 1995, 60, 3112-3120.
6. (a) Rudolph, J.; Theis, H.; Hanke, R.; Endermann, R.; Johannsen, L.; Geschke, F.-U. J. Med. Chem. 2001, 44, 619-626;
7. (b) Nozaki, S. Chem. Lett. 1997, 1-2.
8. Eloy, F.; Lenaers, R. Chem. Rev. 1961, 62, 155-183.
9. Young, J.R.; DeVita, R.J. Tetrahedron Lett. 1998, 39, 3931-3934.