Improved hepatic regeneration with reduced injury by redox factor-1 in a rat small-sized liver transplant model

American Journal of Transplantation

Volumn 4, Issue 6, 2004, Pages 879-887

  Guo, Lei ^a   Haga, Sanae ^b   Enosawa, Shin ^b   Naruse, Katsutoshi ^a   Harihara, Yasushi ^a   Sugawara, Yasuhiko ^a   Irani, Kaikobad ^c   Makuuchi, Masatoshi ^a   Ozaki, Michitaka ^b,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Ischemia reperfusion injury; Redox factor 1 (Ref 1); Regeneration; Small size liver transplant; Stat3

Indexed keywords

ADENOVIRUS VECTOR; ALANINE AMINOTRANSFERASE; BILIRUBIN; REDOX EFFECTOR FACTOR 1; STAT3 PROTEIN; TRANSCRIPTION FACTOR AP 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; EX VIVO STUDY; GENE OVEREXPRESSION; HISTOLOGY; HUMAN; HUMAN CELL; LIVER GRAFT; LIVER INJURY; LIVER PERFUSION; LIVER REGENERATION; LIVER RESECTION; LIVER TRANSPLANTATION; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT;

ADENOVIRIDAE; ALANINE TRANSAMINASE; ANIMALS; BILIRUBIN; CELL DIVISION; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; DNA-BINDING PROTEINS; LIVER; LIVER DISEASES; LIVER REGENERATION; LIVER TRANSPLANTATION; MALE; MODELS, ANIMAL; RATS; RATS, INBRED LEW; REPERFUSION INJURY; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION FACTOR AP-1; TRANSFECTION;

EID: 2942557009     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2004.00444.x     Document Type: Article

References (31)

1. Hashikura Y, Makuuchi M, Kawasaki S et al. Successful living-related partial liver transplantation to an adult patient. Lancet 1994; 343: 1233-1234.
2. Makuuchi M, Kawarazaki H, Iwanaka T, Kamada N, Takayama T, Kumon M. Living related liver transplantation. Surg Today 1992; 22: 297-300.
3. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 1985; 312: 159-163.
4. Burke A, FitzGerald GA, Lucey MR. A prospective analysis of oxidative stress and liver transplantation. Transplantation 2002; 74: 217-221.
5. Barandier C, Tanguy S, Pucheu S, Boucher F, De Leiris J. Effect act of antioxidant trace elements on the response of cardiac tissue to oxidative stress. Ann N Y Acad Sci 1999; 874: 138-155.
6. Sindram D, Rudiger HA, Upadhya AG, Strasberg SM, Clavien PA, Ischemic preconditioning protects against cold ischemic injury through an oxidative stress dependent mechanism. J Hepatol 2002; 36: 78-84.
7. Rigattieri S, Buffon A, Ramazzotti V et al. Oxidative stress in ischemia-reperfusion injury: assessment by three independent biochemical markers. Ital Heart J 2000; 1: 68-72.
8. Ng CK, Deshpande SS, Irani K, Alevriadou BR. Adhesion of flowing monocytes to hypoxia-reoxygenation-exposed endothelial cells-role of Rac1, ROS, and VCAM-1. Am J Physiol Cell Physiol 2002; 283: C93-C102.
9. Sanlioglu S, Williams CM, Samavati L et al. Lipopolysaccharicle induces Racl-dependent reactive oxygen species formation and coordinates tumor necrosis factor-alpha secretion through IKK regulation of NF-kappa B. J Biol Chem 2001; 276: 30188-30198.
10. Deshpande SS, Angkeow P, Huang J, Ozaki M, Irani K. Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: dual regulation by reactive oxygen species. Faseb J 2000; 14: 1705-1714.
11. Ozaki M, Suzuki S, Irani K. Redox factor-1/APE suppresses oxidative stress by inhibiting the racl GTPase. Faseb J 2002; 16: 889-890.
12. Kim KS, Takeda K, Sethi R et al. Protection from reoxygenation injury by inhibition of racl. J Clin Invest 1998; 101: 1821-1826.
13. Demple B, Herman T, Chen DS. Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes. Proc Natl Acad Sci U S A 1991; 88: 11450-11454.
14. Yan M, Xu W, Lu L, Sun L, Liu X, Zheng Z. Induction of ref-1 ensures AP-1 activation in intracellular oxidative environment of IL-2-stimulated BA/F3beta cells. Biochem Biophys Res Commun 2000; 278: 462-469.
15. Jayaraman L, Murthy KG, Zhu C, Curran T, Xanthoudakis S, Prives C. Identification of redox/repair protein Ref-1 as a potent activator of p53. Genes 1997; 11: 558-570.
16. Diamond DA, Parsian A, Hunt CR et al. Redox factor-1 (Ref-1) mediates the activation of AP-1 in HeLa and NIH 3T3 cells in response to heat shock. J Biol Chem 1999; 274: 16959-16964.
17. Hirota K, Matsui M, Iwata S, Nishiyama A, Mori K, Yodoi J. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proc Natl Acad Sci U S A 1997; 94: 3633-3638,
18. Walton M, Lawlor P, Sirimanne E, Williams C, Gluckman P, Dragunow M. Loss of Ref-1 protein expression precedes DNA fragmentation in apoptotic neurons. Brain Res Mol Brain Res 1997; 44: 167-170.
19. Haga S, Terui K, Zhang HQ et al. Stat3 protects against Fas-mediated liver injury in redox-dependent and - independent mechanisms. J Clin Invest 2003; 112: 989-998.
20. Daily D, Vlamis-Gardikas A, Offen D et al. Glutaredoxin protects cerebellar granule neurons from dopamine-induced apoptosis by dual activation of the ras-phosphoinositide 3-kinase and jun n-terminal kinase pathways. J Biol Chem 2001; 276: 21618-21626.
21. Bernal-Mizrachi E, Wen W, Stahlhut S, Welling CM, Permutt MA. Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia. J Clin Invest 2001; 108: 1631-1638.
22. Shioi T, McMullen, Kang PM et al. Akt/protein kinase B promotes organ growth in transgenic mice. Mol Cell Biol 2002; 22: 2799-2809.
23. Shiojima I, Yefremashvili M, Luo Z et al. Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. J Biol Chem 2002; 277: 37670-37677.
24. Vanhaesebroeck B. Alessi DR. The PI3K-PDK1 connection: more than just a road to PKB. Biochem J 2000; 346: 561-576.
25. Ozaki M, Haga S, Zhang HQ, Irani K, Suzuki S. Inhibition of hypoxia/reoxygenation-induced and rac1-regulated oxidative stress in HGF-stimulated anti-apoptotic signaling role of PI3-K and Akt kinase. Cell Death Differ 2003; 10: 508-515.
26. Higgins GM, Anderson RM. Experimental pathology of the liverl Restoration of the liver of the white rat following partial surgical removal. Arch Pathol 1931; 12: 186-202.
27. Kamada N, RY. CalneA surgical experience with five hundred thirty liver transplants in the rat. Surgery 1983; 93: 64-69.
28. Cressman DE, Greenbaum LE, DeAngelis RA et al. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 1996; 274: 1379-1383.
29. Tacchini L, Fusar-Poli D, Bernelli-Zazzera A. Activation of transcription factors by drugs inducing oxidative stress in rat liver. Biochem Pharmacol 2002; 63: 139-148.
30. Stephanou A, Brar BK, Scarabelli TM et al. Ischemia-induced STAT-1 expression and activation play a critical role in cardiomyocyte apoptosis. J Biol Chem 2000; 275: 10002-10008.
31. Stephanou A, Scarabelli TM, Townsend PA et al. The carboxyl-terminal activation domain of the STAT-1 transcription factor enhances ischemia/reperfusion-induced apoptosis in cardiac myocytes. Faseb J 2002; 16: 1841-1843.