Homocysteine-induced inhibition of nitric oxide production in platelets: A study on healthy and diabetic subjects

Diabetologia

Volumn 44, Issue 8, 2001, Pages 979-982

  Mutus, B ^a   Rabini, R A ^a   Staffolani, R ^a   Ricciotti, R ^a   Fumelli, P ^a   Moretti, N ^a   Martarelli, D ^a   Mazzanti, L ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Diabetes mellitus; Homocysteine; Nitric oxide; Platelets

Indexed keywords

HOMOCYSTEINE; NITRIC OXIDE; THROMBIN;

ADULT; ARTICLE; ATHEROGENESIS; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION FUNCTION; DIABETES MELLITUS; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPERHOMOCYSTEINEMIA; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

ADULT; BLOOD PLATELETS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COHORT STUDIES; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; FEMALE; HOMOCYSTEINE; HUMANS; MALE; MIDDLE AGED; NITRIC OXIDE; PLATELET ACTIVATION; PLATELET AGGREGATION; THROMBIN;

EID: 0034887928     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250100581     Document Type: Article

References (10)

1. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease
2. Homocysteine and atherotrombosis
3. Effects of methionine-induced hyperhomocysteinemia on endothelium-dependent vasodilation and oxidative status in healthy adults
4. Homocysteine provokes leukocyte-endothelium interaction by downregulation of nitric oxide
5. An L-arginine/nitric oxide pathway present in human platelets regulates aggregation
6. Decreased nitric oxide synthase activity in platelets from IDDM and NIDDM patients
7. High performance liquid chromatography method for rapid and accurate determination of homocysteine in plasma and serum
8. Constitutive nitric oxide synthase expression in retinal vascular endothelial cells is suppressed by high glucose and advanced glycation end products
9. Homocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells
10. Homocysteine-induced inhibition of endothelium-dependent relaxation in rabbit aorta. Role for superoxide anions