Effect of diazepam on adenosine 3′,5′-cyclic monophosphate (cAMP) plasma levels in anesthetized patients

Clinical Therapeutics

Volumn 26, Issue 5, 2004, Pages 737-743

  Carceles, Maria D ^a   Ribó, Antonio R ^b   Dávalos, Ramón ^a   Martinez, Teresa ^a   Hernández, Jesús ^b,c  

^a HOSPITAL UNIVERSITARIO VIRGEN DE LA ARRIXACA   (Spain)

^b Preventive Medicine and Public Health Unit   (Spain)

^c UNIVERSITY OF MURCIA   (Spain)

Author keywords

Anesthetized patients; cAMP plasma levels; Diazepam; Phosphodiesterase 4

Indexed keywords

ALCOHOL; CATECHOLAMINE DERIVATIVE; CISATRACURIUM; CYCLIC AMP; DIAZEPAM; ETOMIDATE; FENTANYL; OXYGEN; SEVOFLURANE; SODIUM CHLORIDE;

ADRENALIN BLOOD LEVEL; ADULT; ANESTHESIA; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFECT; ELECTIVE SURGERY; FEMALE; HEART MUSCLE REVASCULARIZATION; HEMOCONCENTRATION; HUMAN; MALE; PATIENT SCHEDULING; PROSPECTIVE STUDY; RANDOMIZATION; STATISTICAL SIGNIFICANCE;

EID: 2942544404     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/S0149-2918(04)90073-2     Document Type: Article

References (23)

1. Houslay MD. Adaptation in cyclic AMP signalling processes: A central role for cyclic AMP phosphodiesterases. Semin Cell Dev Biol 1998;9:161-167.
2. Conti M. Cyclic nucleotide phosphodiesterases. In: Conn PM, Means AR, eds. Principles of Molecular Regulations. Totowa, NJ: Humana Press; 2000:261-275.
3. Beavo JA. Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms. Physiol Rev. 1995;75:725-748.
4. Feldman AM, McNamara DM. Reevaluating the role of phosphodiesterase inhibitors in the treatment of cardiovascular disease. Clin Cardiol 2002;25:256-262.
5. Reynolds JEF. Martindale: Extra Pharmacopoeia. 31st ed. London, UK: Pharmaceutical Press; 1996.
6. Collado MC, Beleta J, Martinez E, et al. Functional and biochemical evidence for diazepam as a cyclic nucleotide phosphodiesterase type 4 inhibitor. Br J Pharmacol. 1998;123:1047-1054.
7. Cherry JA, Thompson BE, Pho V. Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse. Biochim Biophys Acta. 2001;1518:27-35.
8. Marín J, Hernández J. Diazepam potentiates the effects of endogenous catecholamines on contractility and cyclic AMP levels in rat ventricular myocardium. Naunyn Schmiedemergs Arch Pharmacol. 2002;365:260-268.
9. Galindo A, Vargas ML, García Estañ J, et al. Synergistic interaction of diazepam with 3′,5′-cyclic adenosine monophosphate-elevating agents on rat aortic rings. Eur J Pharmacol. 2001;428:269-275.
10. York MJ, Davies LP. The effect of diazepam on adenosine uptake and adenosine-stimulated adenylate cyclase in guinea-pig brain. Can J Physiol Pharmacol. 1982;60: 302-307.
11. Vargas ML, Abella C, Hernandez J. Diazepam increases the hypothalamic-pituitary-adrenocortical (HPA) axis activity by a cyclic AMP-dependent mechanism. Br J Pharmacol. 2001;133:1355-1361.
12. Samuelson PN, Reves JG, Kouchoukos NT, et al. Hemodynamic responses to anesthetic induction with midazolam or diazepam in patients with ischemic heart disease. Anesth Analg. 1981;60:802-809.
13. Madsen SN, Moller F, Christiansen C, et al. Cyclic AMP, adrenaline and noradrenaline in plasma during surgery. Br J Surg. 1978;65:191-193.
14. Lindhardt K, Gizurarson S, Stefansson SB, et al. Electroencephalographic effects and serum concentrations after intranasal and intravenous administration of diazepam to healthy volunteers. Br J Clin Pharmacol. 2001;52:521-527.
15. Nishiyama T, Misawa K, Yokoyama T, Hanaoka K. Effects of combining midazolam and barbiturate on the response to tracheal intubation: Changes in autonomic nervous system. J Clin Anesth. 2002;14:344-348.
16. Löfgren A, Hjemdahl P, Olund A, et al. Adrenaline, cyclic AMP and potassium during general anaesthesia with and without epidural analgesia. Eur J Anaesthesiol. 1995;12:487-494.
17. Orlov SN, Maksimova NV. Efflux of cyclic adenosine monophosphate from cells: Mechanisms and physiological implications. Biochemistry. 1999;64:127-135.
18. Thomas NJ, Carcillo JA, Herzer WA, et al. Type IV phosphodiesterase inhibition improves cardiac contractility in endotoxemic rats. Eur J Pharmacol. 2003; 465:133-139.
19. Hoehe M, Duka T. Opiates increase plasma catecholamines in humans. Psychoneuroendocrinology. 1993;18: 141-148.
20. Philipsen EK, Myhre J, Larsen S, et al. The relationship between some beta-adrenergic mediated responses and plasma concentrations of adrenaline and cyclic AMP in man. Acta Endocrinol (Copenh). 1990;122:115-120.
21. Kammer GM. The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response. Immunol Today. 1998;9:222-229.
22. Teixeira MM, Gristwood RW, Cooper N, Hellewell PG. Phosphodiesterase (PDE)4 inhibitors: Antiinflammatory drugs of the future? Trends Pharmacol Sci. 1997;18:164-171.
23. Pawlikowski M. Immunomodulating effects of peripherally acting benzodiazepines. In: Giesen-Crouse E, ed. Peripheral Benzodiazepine Receptors. London, UK: Academic Press; 1993:125-135.