Functional and biochemical evidence for diazepam as a cyclic nucleotide phosphodiesterase type 4 inhibitor

British Journal of Pharmacology

Volumn 123, Issue 6, 1998, Pages 1047-1054

  Collado, M Carmen ^a   Beleta, Jorge ^b   Martinez, Ester ^a   Miralpeix, Montse ^b   Domènech, Teresa ^b   Palacios, José Maria ^b   Hernández, Jesús ^c  

^a Medical School   (Spain)

^b Almirall Prodesfarma ^*  (Spain)

^c Facultad de Medicina   (Spain)

Author keywords

Benzodiazepines; Cardiac contractility; Cyclic AMP; Diazepam; Milrinone; Phosphodiesterase; Rolipram; SKandF 94120

Indexed keywords

4 AMINOBUTYRIC ACID; BENZODIAZEPINE DERIVATIVE; CYCLIC AMP; CYCLIC GMP PHOSPHODIESTERASE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; DIAZEPAM; DRUG RECEPTOR; ISOPRENALINE; MILRINONE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM; TRITIUM;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN MEMBRANE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; ENZYME INHIBITION; EOSINOPHIL; GUINEA PIG; HEART CONTRACTION; HEART RIGHT VENTRICLE; INOTROPISM; NONHUMAN; PRIORITY JOURNAL; RADIOASSAY;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; CHLORIDE CHANNELS; CYCLIC AMP; DIAZEPAM; DRUG INTERACTIONS; EOSINOPHILS; GAMMA-AMINOBUTYRIC ACID; GUINEA PIGS; HEART; ISOENZYMES; ISOPROTERENOL; MYOCARDIAL CONTRACTION; PHOSPHODIESTERASE INHIBITORS; PYRROLIDINONES; RATS; RECEPTORS, GABA-A; ROLIPRAM; TRITIUM;

EID: 0031886404     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701698     Document Type: Article

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