The human chorionic gonadotropin molecule from patients with trophoblastic diseases has a high thyrotropic activity but is less active in the ovary

Gynecological Endocrinology

Volumn 18, Issue 5, 2004, Pages 269-277

  Kato, K ^a,b   Mostafa, M H ^a,c   Mann, K ^a   Schindler, A E ^a   Hoermann, R ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b Maternity Hospital ^*  (Germany)

^c AIN SHAMS UNIVERSITY   (Egypt)

Author keywords

Chinese Hamster Ovary; Human Chorionic Gonadotropin; Hyperthyroidism; Thyroid; Trophoblastic Disease

Indexed keywords

CHORIONIC GONADOTROPIN; CYCLIC AMP; LUTEINIZING HORMONE RECEPTOR; THYROTROPIN RECEPTOR;

ADOLESCENT; ADULT; ANIMAL CELL; ARTICLE; CELL LINE; CHINESE HAMSTER; CHORIOCARCINOMA; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HORMONE ACTION; HUMAN; HYPERTHYROIDISM; NONHUMAN; OVARY; PREGNANCY; PRIORITY JOURNAL; TROPHOBLASTIC DISEASE;

ADOLESCENT; ADULT; ANIMALS; CHO CELLS; CHORIOCARCINOMA; CHORIONIC GONADOTROPIN; CRICETINAE; CYCLIC AMP; ESTRADIOL; FEMALE; HUMANS; HYDATIDIFORM MOLE; HYPERTHYROIDISM; MIDDLE AGED; OVARY; PREGNANCY; PROGESTERONE; RECEPTORS, LH; THYROTROPIN; THYROXINE; UTERINE NEOPLASMS;

EID: 2942536686     PISSN: 09513590     EISSN: None     Source Type: Journal    
DOI: 10.1080/09513590410001667247     Document Type: Article

References (28)

1. Berkowitz RS, Goldstein DP. Chorionic tumors. N Engl J Med 1996;335:1740-8
2. Seckl M, Fisher RA, Salerno G, et al. Choriocarcinoma and partial hydatidiform moles. Lancet 2000;356:36-9
3. Goodwin TM, Hershman JM. Hyperthyroidism due to inappropriate production of human chorionic gonadotropin. Clin Obstet Gynecol 1997;40:32-44
4. Franz CR, Dagogo-Jack S, Ladenson JH, et al. Thyroid function during pregnancy. Clin Chem 1999;45:2250-8
5. Okamoto T, Matsuo K, Niu R, et al. Human chorionic gonadotropin (hCG) β-core fragment is produced by degradation of hCG or free hCGjβ in gestational trophoblastic tumors: a possible marker for early detection of persistent postmolar gestational trophoblastic disease. J Endocrinol 2001;171:435-43
6. Talbot JA, Lambert A, Anobiles CJ, et al. The nature of human chorionic gonadotrophin glycoforms in gestational thyrotoxicosis. Clin Endocrinol 2001;55:33-9
7. Cole LA, Shahabi S, Butler SA, et al. Utility of commonly used commercial human chorionic gonadotropin immunoassays in the diagnosis and management of trophoblastic diseases. Clin Chem 2001;47:308-15
8. Elliot MM, Kardana A, Lustbader JW, et al. Carbohydrate and peptide structure of the alpha-and beta-subunits of human chorionic gonadotropin from normal and aberrant pregnancy and choriocarcinoma. Endocrine 1997;7:15-32
9. Lustbader JW, Lobel L, Wu H, et al. Structural and molecular studies of human chorionic gonadotropin and its receptor. Rec Prog Horm Res 1998;53:395-425
10. Kraiem Z, Lahat N, Sadeh O, et al. Desialylated and deglycosylated human chorionic gonadotropin are superagonists of native human chorionic gonadotropin in human thyroid follicle. Thyroid 1997;7:783-8
11. Hoermann R, Brocker M, Grossmann M, et al. Interaction of human chorionic gonadotropin (hCG) and asialo-hCG with recombinant human thyrotropin receptors. J Clin Endocrinol Metab 1994;78:933-8
12. Hoermann R, Poertl S, Liss I, et al. Variation in the thyrotropic activity of human chorionic gonadotropin in Chinese hamster ovary cells arises from differential expression of the human thyrotropin receptor and microheterogeneity of the hormone. J Clin Endocrinol Metab 1995;80:1605-10
13. Kato K, Mostafa MH, Mann K, et al. Immunological and biological activity of different commercial preparations of human chorionic gonadotropin. Zentralbl Gynaekol 2002;124:123-7
14. Kato K, Mostafa MH, Mann K, et al. Human chorionic gonadotropin exhibits normal biological activity in patients with recurrent pregnancy loss. Gynecol Endocrinol 2002;16:179-86
15. Schulz A, Schöneberg T, Paschke R, et al. Role of the third intracellular loop for the activation of gonadotropin receptors. Mol Endocrinol 1999;13:181-90
16. Lazarus J, Kokandi A. Thyroid disease in relation to preganancy: a decade of change. Clin Endocrinol 2000;53:265-78
17. Jordan V, Grebe SKG, Cooke RR, et al. Acidic isoforms of chorionic gonadotrophin in European and Samoan women are associated with hyperemesis gravidarum and may be thyrotrophic. Clin Endocrinol 1999;50:619-27
18. Kenimer JG, Hershman JM, Higgins HP, et al. The thyrotropin in hydatidiform moles is human chorionic gonadotropin. J Clin Endocrinol Metab 1975;40:482-91
19. Azukizawa M, Kurtzman G, Pekary AE, et al. Comparison of the binding characteristics of bovine thyrotropin and human chorionic gonadotropin to thyroid membranes. Endocrinology 1977;101:1880-9
20. Yoshimura M, Nishikawa M, Mori Y, et al. Human chorionic gonadotropin induces c-myc mRNA expression via TSH receptor in FRTL-5 rat thyroid cells. Thyroid 1992;2:315-19
21. Poertl S, Liss I, Mann K, et al. Crude urinary human chorionic gonadotropin contains variant forms of hCG with low sialic acid content that exhibit an increased thyrotropic activity in CHO cells expressing the human TSH receptor. Exp Clin Endocrinol 1995;103:168-74
22. Hershman JM. Role of human chorionic gonadotropin as a thyroid stimulator. J Clin Endocrinol Metab 1992;74:258-9
23. Grün JP, Meuris S, De Nayer P, et al. The thyrotropic role of human chorionic gonadotropin (hCG) in the early stages of twin (versus single) pregnancies. Clin Endocrinol 1997;46:719-25
24. Foulk RA, Musci TJ, Schriock ED, et al. Does human chorionic gonadotropin have human thyrotropic activity in vivo? Gynecol Endocrinol 1997;11:195-201
25. Sakaguchi N, Yoshimura M, Nishikawa M, et al. Maternal thyroid function in multiple pregnancy: the variable thyrotropic activity of human chorionic gonadotropin. Horm Metab Res 1998;30:689-93
26. Khan S, Katabuchi H, Araki M, et al. The molar vesicle fluid contains the beta-core fragment of human chorionic gonadotropin. Placenta 2000;21:79-87
27. Mungan T, Kuscu E, Ugur M, et al. Screening of persistant trophoblastic disease with various serum markers. Eur J Gynecol Oncol 1998;19:495-7
28. Nishimura R, Koizumi T, Yokotani T, et al. Molecular heterogeneity of hCGβ-related glycoproteins and the clinical relevance in trophoblastic and non-trophoblastic tumors. Int J Gynaecol Obstet 1998;60(Suppl 1):29-32