Evaluation of the anticarcinogenic activity of Swertia chirata Buch.Ham, an Indian medicinal plant, on DMBA-induced mouse skin carcinogenesis model

Phytotherapy Research

Volumn 18, Issue 5, 2004, Pages 373-378

  Saha, Prosenjit ^a   Mandal, Suvra ^b   Das, Ashes ^b   Das, Prabhas C ^b   Das, Sukta ^a  

^a CHITTARANJAN NATIONAL CANCER INSTITUTE   (India)

^b Central Research Institute Ayurveda   (India)

Author keywords

Amarogentin; Apoptosis; Cancer chemoprevention; Cell proliferation; Detoxification enzymes; Swertia chirata

Indexed keywords

AMAROGENTIN; ANTIOXIDANT; AYURVEDIC DRUG; CATALASE; DIMETHYLBENZ[A]ANTHRACENE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; HERBACEOUS AGENT; SUPEROXIDE DISMUTASE; SWERTIA CHIRATA EXTRACT; SWERTIA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOTRANSFORMATION; CANCER PREVENTION; CELL PROLIFERATION; CHIRATA; CONTROLLED STUDY; DETOXIFICATION; DRUG EFFECT; DRUG SCREENING; ENZYME ACTIVATION; ENZYME PURIFICATION; LIPID PEROXIDATION; MEDICINAL PLANT; METABOLIC ACTIVATION; MOUSE; NONHUMAN; SKIN CARCINOGENESIS; SKIN PAPILLOMA; SWERTIA;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL DIVISION; INDIA; MALE; MEDICINE, TRADITIONAL; MICE; PAPILLOMA; PHYTOTHERAPY; PLANT EXTRACTS; SKIN NEOPLASMS; SWERTIA;

SWERTIA;

EID: 2942532402     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1436     Document Type: Article

References (26)

1. Amonkar AJ, Adwankar MK 1997. Screening of anticancer drugs. In Techniques in Cancer Research - A Laboratory Manual, Deo MG, Seshadri R, Mulherker R, Bhisey AN (eds). NISCOM: New Delhi; 362.
2. Bland J. 1986. 1986 - A Year in Nutritional Medicine, Bland J. (ed.). Keats: New Canaan, CT; 293.
3. Chatterjee A, Pakrashi SC. 1995. The Treatise on Indian Medicinal Plants, Vol. 4. Publications and Information Directorate, CSIR: New Delhi; 92-94.
4. Habig WH, Pabst MJ, Jacoby WB. 1974. Glutathione-S-transferase: the first enzymatic step in mercapturic acid formation. J Biol Chem 249: 7130-7139.
5. Halliwell B, Gutteridge JMC. 1989. Free Radicals in Biology and Medicine. Clarendon Press: Oxford.
6. Karan M, Vasisht K, Handa SS. 1999a. Antihepatotoxic activity of Swertia chirata on paracetamol and galactosamine induced hepatotoxicity in rats. Phytother Res 13: 95-101.
7. Karan M, Vasisht K, Handa SS. 1999b. Antihepatotoxic activity of Swertia chirata on carbon tetrachloride induced hepatotoxicity in rats. Phytother Res 13: 24-30.
8. Khanom F, Kayahara H, Tadasa K. 2000. Superoxide scavenging and prolyl endopeptidase inhibitory activities of Bangladeshi indigenous medicinal plants. Biosc Biotechnol Biochem 64: 837-884.
9. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-276.
10. Luck H. 1963. A spectrophotometric method for the estimation of catalase. In Methods of Enzymatic Analysis, HV Bergmeyer (ed.). Academic Press: New York; 886-888.
11. Mandal S, Chatterjee A. 1987. Structure of chirantanin, a novel dimeric xanthone. Tetrahedron Lett 28: 1309-1310.
12. Mandal S, Das PC, Joshi PC, et al. 1992. Antiinflammatory action of Swertia chirata. Fitotherapia 63: 122-128.
13. Mandal S, Joshi PC, Das PC. 1997. Drug value of Swertia chirata and its phytoconstituents. Bull Medico EthnoBotany Res 18: 82-88.
14. Marklund S, Marklund G. 1974. Involvement of the superoxide anion radical in the auto oxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47: 469-474.
15. Medda S, Mukhopadhyay S, Basu MK. 1999. Evaluation of the in vivo activity and toxicity of amarogentin, an anti-leishmanial agent, in both liposomal and niosomal forms. J Antimicrob Chemother 44: 791-794.
16. Okhawa H, Ohishi N, Yagi K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Annal Biochem 95: 351-358.
17. Paglia DE, Valentine, WN. 1967. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70: 158-169.
18. Potten CS. 1981. Cell replacement in epidermis (Keratopoiesis) via discrete units of proliferation. Int Rev of Cytology 69: 271-317.
19. Potten CS. 1992. Cell images. In Oxford Text Book of Pathology, Vol. 1, McGee JO'D, Isaacson PG, Wright NA (eds). Oxford University Press: Oxford; 43-52.
20. Rafatullah S, Tariq M, Mossa JS, et al. 1993. Protective effect of Swertia chirata against indomethacin and other ulcerogenic agent induced gastric ulcers. Drugs Exp Clin Res 19: 69-73.
21. Ray S, Majumder HK, Chakravarty AK, et al. 1996. Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani. J Nat Prod 59: 27-29.
22. Richter C, Park JW, Ames BN. 1988. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sc USA 85: 6465-6467.
23. Sedlack J, Lindsay RN. 1968. Estimation of total protein bound and non-protein sulphydryl groups in tissues with Ellman reagent. Anal Biochem 25: 192-205.
24. Szarka CE, Pfeiffer GR, Hum ST, et al. 1995. Glutathione-S-transferase activity and glutathione-S transferase u expression in subjects with risk for colorectal cancer. Cancer Res 55:2789-2793.
25. Vang O, Rasmussen BF, Anderson O. 1997. Combined effects of complex mixtures of potentially anticarcinogenic compounds on antioxidant enzymes and carcinogen metabolizing enzymes in the rat. Cancer Lett 114: 283-286.
26. Vaux D, Korsmeyer S. 1999. Cell death in development. Cell 96: 245-254.