Functional expression of NF1 tumor suppressor protein: Association with keratin intermediate filaments during the early development of human epidermis

BMC Dermatology

Volumn 2, Issue , 2002, Pages

  Malminen, Maria ^a   Peltonen, Sirkku ^a   Koivunen, Jussi ^b   Peltonen, Juha ^a,b  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF OULU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ALPHA TUBULIN; CYTOKERATIN 14; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; KERATIN; NEUROFIBROMIN; PROTEIN P21; RAS PROTEIN; TUMOR SUPPRESSOR PROTEIN; MESSENGER RNA;

ARTICLE; BASAL CELL; BASEMENT MEMBRANE; CELL DIFFERENTIATION; CELL JUNCTION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOSKELETON; DESMOSOME; EPIDERMIS; FETUS; FETUS DEVELOPMENT; GENE MUTATION; GESTATIONAL AGE; HEMIDESMOSOME; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOELECTRON MICROSCOPY; IMMUNOFLUORESCENCE; IN SITU HYBRIDIZATION; INTERMEDIATE FILAMENT; KERATINOCYTE; NEUROFIBROMATOSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; ADULT; ANIMAL; CELL CULTURE; CONFOCAL MICROSCOPY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; PRENATAL DEVELOPMENT;

ADULT; ANIMALS; CELLS, CULTURED; EPIDERMIS; FLUORESCENT ANTIBODY TECHNIQUE; GESTATIONAL AGE; HUMANS; IN SITU HYBRIDIZATION; INTERMEDIATE FILAMENTS; KERATINOCYTES; KERATINS; MICROSCOPY, CONFOCAL; MICROSCOPY, IMMUNOELECTRON; NEUROFIBROMIN 1; RNA, MESSENGER;

EID: 2942527028     PISSN: 14715945     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-5945-2-10     Document Type: Article

References (33)

1. Holbrook KA, Odland GF: The fine structure of developing human epidermis: light, scanning, and transmission electron microscopy of the periderm. J Invest Dermatol 1975, 65:16-38
2. McMillan JR, Eady RA: Hemidesmosome ontogeny in digit skin of the human fetus. Arch Dermatol Res 1996, 288:91-97
3. Holbrook KA: Development of human skin. Retinoids 1997, 13:47-53
4. Dale BA, Holbrook KA, Kimball JR, M Hoff, Sun TT: Expression of epidermal keratins and filaggrin during human fetal skin development. J Cell Biol 1985, 101:1257-1269
5. Hentula M, Peltonen J, Peltonen S: Expression profiles of cell-cell and cell-matrix junction proteins in developing human epidermis. Arch Dermatol Res 2001, 293:259-267
6. Pummi K, Malminen M, Aho H, Karvonen SL, Peltonen J, Peltonen S: Epidermal tight junctions: ZO-1 and occludin are expressed in mature, developing, and affected skin and in vitro differentiating keratinocytes. J Invest Dermatol 2001, 117:1050-1058
7. Vasioukhin V, Bauer C, Degenstein L, Wise B, Fuchs E: Hyperproliferation and defects in epithelial polarity upon conditional ablation of α-catenin in skin. Cell 2001, 104:605-617
8. Gutmann DH, Wood DL, Collins FS: Identification of the neurofibromatosis type 1 gene product. Proc Natl Acad Sci U S A 1991, 88:9658-9662
9. Gutmann DH, Aylsworth A, Carey JC, Korf B, Marks J, Pyeritz RE, Rubenstein A, Viskochil D: The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2. JAMA 1997, 278:51-57
10. Marchuk DA, Saulino AM, Tavakkol R, Swaroop M, Wallace MR, Andersen LB, Mitchell AL, Gutmann DH, Boguski M, Collins FS: cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product. Genomics 1991, 11:931-940
11. Riccardi VM: Von Recklinghausen neurofibromatosis. N Engl J Med 1981, 305:1617-1627
12. Xu GF, Lin B, Tanaka K, Dunn D, Wood D, Gesteland R, White R, Weiss R, Tamanoi F: The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae. Cell 1990, 63:835-841
13. Bollag G, McCormick F: Ras regulation. NF is enough of GAP. Nature 1992, 356:663-664
14. Mercer JA: Intercellular junctions: downstream and upstream of Ras? Semin Cell Dev Biol 2000, 11:309-314
15. Legius E, Marchuk DA, Collins FS, Glover TW: Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis. Nat Genet 1993, 3:122-126
16. Li Y, Bollag G, Clark R, Stevens J, Conroy L, Fults D, Ward K, Friedman E, Samowitz W, Robertson M: Somatic mutations in the neurofibromatosis 1 gene in human tumors. Cell 1992, 69:275-281
17. Johnson MR, Look AT, DeClue JE, Valentine MB, Lowy DR: Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP-Ras. Proc Natl Acad Sci U S A 1993, 90:5539-5543
18. Gutmann DH, Geist RT, Rose K, Wallin G, Moley JF: Loss of neurofibromatosis type I (NF1) gene expression in pheochromocytomas from patients without NF1. Genes Chromosomes Cancer 1995, 13:104-109
19. Gutmann DH, Giordano MJ, Mahadeo DK, Lau N, Silbergeld D, Guha A: Increased neurofibromatosis 1 gene expression in astrocytic tumors: positive regulation by p21-ras. Oncogene 1996, 12:2121-2127
20. Hermonen J, Hirvonen O, Ylä-Outinen H, Lakkakorpi J, Björkstrand AS, Laurikainen L, Kallioinen M, Oikarinen A, Peltonen S, Peltonen J: Neurofibromin: expression by normal human keratinocytes in vivo and in vitro and in epidermal malignancies. Lab Invest 1995, 73:221-228
21. Peltonen J, Karvonen SL, Ylä-Outinen H, Hirvonen O, Karvonen J: Lesional psoriatic epidermis displays reduced neurofibromin immunoreactivity. J Invest Dermatol 1995, 105:664-667
22. Aaltonen V, Boström PJ, Söderström KO, Hirvonen O, Tuukkanen J, Nurmi M, Laato M, Peltonen J: Urinary bladder transitional cell carcinogenesis is associated with down-regulation of NF1 tumor suppressor gene in vivo and in vitro. Am J Pathol 1999, 154:755-765
23. Brannan CI, Perkins AS, Vogel KS, Ratner N, Nordlund ML, Reid SW, Buchberg AM, Jenkins NA, Parada LF, Copeland NG: Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev 1994, 8:1019-1029
24. Daston MM, Ratner N: Neurofibromin, a predominantly neuronal GTPase activating protein in the adult, is ubiquitously expressed during development. Dev Dyn 1992, 195:216-226
25. Hirvonen O, Lakkakorpi J, Aaltonen V, Hirvonen H, Rossi M, Karvonen SL, Ylä-Outinen H, Kalimo H, Peltonen J: Developmental regulation of NF1 tumor suppressor gene in human peripheral nerve. J Neurocytol 1998, 27:939-952
26. Baizer L, Ciment G, Hendrickson SK, Schafer GL: Regulated expression of the neurofibromin type I transcript in the developing chicken brain. J Neurochem 1993, 61:2054-2060
27. Huynh DP, Nechiporuk T, Pulst SM: Differential expression and tissue distribution of type I and type II neurofibromins during mouse fetal development. Dev Biol 1994, 161:538-551
28. Koivunen J, Ylä-Outinen H, Korkiamäki T, Karvonen SL, Pöyhönen M, Laato M, Karvonen J, Peltonen S, Peltonen J: New function for NF1 tumor suppressor. J Invest Dermatol 2000, 114:473-479
29. Li C, Cheng Y, Gutmann DA, Mangoura D: Differential localization of the neurofibromatosis 1 (NF1) gene product, neurofibromin, with the F-actin or microtubule cytoskeleton during differentiation of telencephalic neurons. Brain Res Dev Brain Res 2001, 130:231-248
30. Hsueh YP, Roberts AM, Volta M, Sheng M, Roberts RG: Bipartite interaction between neurofibromatosis type I protein (neurofibromin) and syndecan transmembrane heparan sulfate proteoglycans. J Neurosci 2001, 21:3764-3770
31. 2+-induced keratinocyte differentiation. Lab Invest 2002, 82:353-361
32. Hirvonen O, Lakkakorpi J, Aaltonen V, Hirvonen H, Rossi M, Karvonen SL, Ylä-Outinen H, Kalimo H, Peltonen J: Developmental regulation of NF1 tumor suppressor gene in human peripheral nerve. J Neurocytol 1998, 27:939-952
33. Malhotra R, Ratner N: Localization of neurofibromin to keratinocytes and melanocytes in developing rat and human skin. J Invest Dermatol 1994, 102:812-818