New function for NF1 tumor suppressor

Journal of Investigative Dermatology

Volumn 114, Issue 3, 2000, Pages 473-479

  Koivunen, Jussi ^a   Ylä Outinen, Heli ^a   Korkiamäki, Timo ^a   Karvonen, Seija Liisa ^a   Pöyhönen, Minna ^b   Laato, Matti ^c   Karvonen, Jaakko ^a   Peltonen, Sirkku ^c   Peltonen, Juha ^a,c  

^a UNIVERSITY OF OULU   (Finland)

^b Vaestoliitto   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

Author keywords

Cell adhesion; Cytoskeleton; Desmosome; Neurofibromatosis

Indexed keywords

CALCIUM ION; NEUROFIBROMIN;

ADULT; AGED; ARTICLE; CELL DIFFERENTIATION; CELL JUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; DESMOSOME; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERMEDIATE FILAMENT; KERATINOCYTE; NEUROFIBROMATOSIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TUMOR SUPPRESSOR GENE;

EID: 0034047118     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2000.00882.x     Document Type: Article

References (43)

1. Aaltonen V, Boström PJ, Söderström K-O, et al: Urinary bladder transitional cell carcinogenesis is associated with down-regulation of Nf1 tumor suppressor gene in vivo and in vitro. Am J Pathol 154:755-765, 1999
2. Basu TN, Gutmann DH, Fletcher JA, Glower TW, Collins FS, Downward J: Aberrant regulation of ras proteins in malignant tumour cells from type I neurofibromatosis patients. Nature 356:713-715, 1992
3. Blatt J, Jaffe R, Deutsch M, Adkins JC: Neurofibromatosis and childhood tumors. Cancer 57:1225-1229, 1986
4. Bollag G, McCormick F: NF is enough of GAP. Nature 35:663-664, 1992
5. Bollag G, McCormick F, Clark R: Characterization of full-length neurofibromin: tubulin inhibits Ras-GAP activity. EMBO J 12:1923-1927, 1993
6. Boyce ST, Ham RG: Cultivation, frozen storage, and clonal growth of normal human keratinocytes in serum free media. J Tissue Cult Meth 9:83-93, 1985
7. DeClue JE, Papageorge AG, Fletcher JA, Diehl SR, Ratner N, Vass WC, Lowy D: Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type I) neurofibromatosis. Cell 69:265-273, 1992
8. Eckert RL, Crish JF, Robinson NA: The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation. Physiol Rev 77:397-424, 1997
9. Fey EG, Wan KM, Penman S: Epithelial cytoskeletal framework and nuclear matrix-intermediate filament scaffold: three-dimensional organization and protein composition. J Cell Biol 98:1973-1984, 1984
10. Garrod DR: Desmosomes and hemidesmosomes. Curr Opin Cell Biol 5:30-40, 1993
11. Garrod D, Chidgey M, North A: Desmosomes: differentiation, development, dynamics and disease. Curr Opin Cell Biol 8:670-678, 1996
12. Green KJ, Geiger B, Jones JC, Talian JC, Goldman RD: The relationship between intermediate filaments and microfilaments before and during the formation of desmosomes and adherens type junctions in mouse epidermal keratinocytes. J Cell Biol 104:1389-1402, 1987
13. Gregory PE, Gutmann DH, Mitchell A, et al: Neurofibromatosis type 1 gene product (neurofibromin) associates with microtubules. Somat Cell Mol Genet 19:265-274, 1993
14. Griesser J, Kaufmann D, Eisenbarth I, Bauerle C, Krone W: Ras-GTP regulation is not altered in cultured melanocytes with reduced levels of neurofibromin derived from patients with neurofibromatosis 1 (NF1). Biol Chem Hoppe Seyler 376:91-101, 1995
15. Griesser J, Kaufmann D, Maier B, Mailhammer R, Kuehl P, Krone W: Posttranscriptional regulation of neurofibromin level in cultured human melanocytes in response to growth factors. J Invest Dermatol 108:275-280, 1997
16. Guo HF, The I, Hannan F, Bernards A, Zhong Y: Requirement of Drosophila NF1 for activation of adenylyl cyclase by PACAP38-like neuropeptides. Science 276:795-798, 1997
17. Gutmann DH, Wood DL, Collins FS: Identification of the neurofibromatosis type 1 gene product. Proc Natl Acad Sci USA 88:9658-9662, 1991
18. Gutmann DH, Geist RT, Rose K, Wallin G, Moley JF: Loss of neurofibromatosis type 1 (NF1) gene expression in pheochromocytomas from patients without NF1. Genes, Chromosomes Cancer 13:104-109, 1995a
19. Gutmann DH, Geist RT, Rose K, Wright DE: Expression of two new protein isoforms of the neurofibromatosis type 1 gene product, neurofibromin, in muscle tissues. Dev Dyn 202:302-311, 1995b
20. Gutmann DH, Giordano MJ, Mahadeo DK, Lau N, Silbergeld D, Guha A: Increased neurofibromatosis 1 gene expression in astrocytic tumors: positive regulation by p21-ras. Oncogene 12:2121-2127, 1996
21. Gutmann DH, Aylsworth A, Carey JC, Korf B, Marks J, Pyeritz RE, Rubenstein A, Viskochil D: The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2. JAMA 278:51-57, 1997
22. Haftek M, Hansen MU, Kaiser HW, Kreysel HW, Schmitt D: Interkeratinocyte adherens junctions: immunocytochemical visualization of cell-cell junctional structures, distinct from desmosomes, in human epidermis. J Invest Dermatol 106:498-504, 1996
23. Hattori S, Maekawa M, Nakamura S: Identification of neurofibromatosis type I gene product as an insoluble GTPase-activating protein toward ras p21. Oncogene 7:481-485, 1992
24. Hermonen J, Hirvonen O, Ylä-Outinen H, et al: Neurofibromin: expression by normal human keratinocytes in vivo and in vitro, and in epidermal malignancies. Lab Invest 73:221-228, 1995
25. Jaakkola S, Muona P, James W, Hannuksela M, Karvonen J, Peltonen J, Uitto J: Segmental neurofibromatosis: Immunocytochemical analysis of cutaneous lesions. J Am Acad Dermatol 22:617-621, 1990
26. Johnson MR, Look AT, DeClue JE, Valentine MB, Lowy DR: Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras. Proc Natl Acad Sci USA 90:5539-5543, 1993
27. Johnson MR, DeClue JE, Felzmann S, Vass WC, Xu G, White R, Lowy DR: Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function. Mol Cell Biol 14:641-645, 1994
28. Jones JCR, Goldman RD: Intermediate filaments and the initiation of desmosome assembly. J Cell Biol 101:506-517, 1985
29. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685, 1970
30. Legius E, Marchuk DA, Collins FS, Glover TW: Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis. Nat Genet 3:122-126, 1993
31. Li Y, White R: Suppression of a human colon cancer cell line by introduction of an exogenous NF1 gene. Cancer Res 56:2872-2876, 1996
32. Li Y, Bollag G, Clark R, et al: Somatic mutations in the neurofibromatosis 1 gene in human tumors. Cell 69:275-281, 1992
33. Malhotra R, Ratner N: Localization of neurofibromin to keratinocytes and melanocytes in developing rat and human skin. J Invest Dermatol 102:812-818, 1994
34. Marchuk DA, Saulino AM, Tavakkol R, et al: CDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product. Genomics 11:931-940, 1991
35. Metheny LJ, Cappione AJ, Skuse GR: Genetic and epigenetic mechanisms in the pathogenesis of neurofibromatosis type I. J Neurolpathol Exp Neurol 54:753-760, 1995
36. Pasdar M, Nelson WJ: Kinetics of desmosome assembly in Madin-Darby canine kidney epithelial cells: temporal and spatial regulation of desmoplakin organization and stabilization upon cell-cell contact. I. Biochemical analysis. J Cell Biol 106:677-685, 1988
37. Peltonen J, Foidart JM, Aho HJ: Type IV and V collagens in von Recklinghausen's neurofibromas. An immunohistochemical and electrophoretical study. Virchows Arch B Cell Pathol Ind Mol Pathol 47:291-301, 1984
38. Peltonen J, Jaakkola S, Lebwohl M, Renvall S, Risteli L, Virtanen I, Uitto J: Cellular differentiation and expression of matrix genes in type 1 neurofibromatosis. Lab Invest 59:760-771, 1988
39. Peltonen J, Karvonen S-L, Ylä-Outinen H, Hirvonen O, Karvonen J: Lesional psoriatic epidermis displays reduced neurofibromin immunoreactivity. J Invest Dermatol 105:664-667, 1995
40. Riccardi V: Von Recklinghausen neurofibromatosis. N Engl J Med 305:1617-1627, 1981
41. Ryynänen J, Jaakkola S, Engvall E, Peltonen J, Uitto J: Expression of β4-integrins in human skin: Comparison of epidermal distribution with β1-integrin epitopes, and modulation by calcium and vitamin D3 in cultured keratinocytes. J Invest Dermatol 97:562-567, 1991
42. The I, Hannigan GE, Cowley GS, et al: Rescue of a Drosophila NF1 mutant phenotype by protein kinase A. Science 276:791-794, 1997
43. Xu GF, Lin B, Tanaka K, et al: The catalytic domain of neurofibromatosis type I gene product stimulates ras GTPase and complements ira mutants of S. Cerevisae Cell 63:835-841, 1990