The manganese-responsive repressor Mur of the Rhizobium leguminosarum is a member of the Fur-superfamily that recognizes an unusual operator sequence

Microbiology

Volumn 151, Issue 12, 2005, Pages 4071-4078

  Díaz Mireles, Edit ^a   Wexler, Margaret ^a   Todd, Jonathan D ^a   Bellini, Dominico ^a   Johnston, Andew W B ^a   Sawers, R Gary ^b  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b JOHN INNES CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; BACTERIAL PROTEIN; DEOXYRIBONUCLEASE I; DNA BINDING PROTEIN; IRON; IRON REGULATORY FACTOR; MANGANESE; MANGANESE UPTAKE REGULATOR; RNA POLYMERASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; BRADYRHIZOBIUM JAPONICUM; CONTROLLED STUDY; DNA SEQUENCE; GENETIC CODE; GENETIC TRANSCRIPTION; IN VITRO STUDY; NONHUMAN; OPERATOR GENE; OPERON; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN TRANSPORT; RHIZOBIUM LEGUMINOSARUM; SEQUENCE HOMOLOGY;

BACTERIAL PROTEINS; BINDING SITES; DNA; GENE EXPRESSION REGULATION, BACTERIAL; IRON; MANGANESE; OPERATOR REGIONS (GENETICS); OPERON; REPRESSOR PROTEINS; RHIZOBIUM LEGUMINOSARUM; TRANSCRIPTION, GENETIC;

BACTERIA (MICROORGANISMS); BRADYRHIZOBIUM JAPONICUM; RHIZOBIUM LEGUMINOSARUM;

EID: 29244471715     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.28342-0     Document Type: Article

References (27)

1. Andrews, S. C., Robinson, A. K. & Rodríguez-Quiñones, F. (2003). Bacterial iron homeostasis. FEMS Microbiol Rev 27, 215-237.
2. Baichoo, N. & Helmann, J. D. (2002). Recognition of DNA by Fur: a reinterpretation of the Fur box consensus sequence. J Bacteriol 184, 5826-5832.
3. Beringer, J. E. (1974). R factor transfer in Rhizobium leguminosarum. J Gen Microbiol 84, 188-198.
4. Chao, T.-C., Becker, A., Buhrmester, J., Pühler, A. & Weidner, S. (2004). The Sinorhizobium meliloti fur gene regulates in dependence of Mn(II) the transcription of the sitABCD operon encoding a metal type transporter. J Bacteriol 186, 3609-3620.
5. de Luca, N. G., Wexler, M., Pereira, M. J., Yeoman, K. H. & Johnston, A. W. B. (1998). Is the fur gene of Rhizobium leguminosarum essential? FEMS Microbiol Lett 168, 289-295.
6. 2+-responsive transcriptional regulator. Microbiology 150, 1447-1456.
7. Escolar, L., Pérez-Martín, J. & de Lorenzo, V. (1999). Opening the iron box: transcriptional metalloregulation by the Fur protein. J Bacteriol 181, 6223-6229.
8. Friedman, Y. E. & O'Brian, M. R. (2003). A novel DNA-binding site for the ferric uptake regulator (Fur) protein from Bradyrhizobium japonicum. J Biol Chem 278, 38395-38401.
9. Friedman, Y. E. & O'Brian, M. R. (2004). The ferric uptake regulator (Fur) protein from Bradyrhizobium japonicum is an iron-responsive transcriptional repressor in vitro. J Biol Chem 279, 32100-32105.
10. Fuangthong, M. & Helmann, J. D. (2003). Recognition of DNA by three ferric uptake regulator (Fur) homologs in Bacillus subtilis. J Bacteriol 185, 6348-6357.
11. Hamza, I., Qi, Z., King, N. D. & O'Brian, M. R. (2000). Furindependent regulation of iron metabolism by Irr in Bradyrhizobium japonicum. Microbiology 146, 669-676.
12. Hantke, K. (2001). Iron and metal regulation in bacteria. Curr Opin Microbiol 4, 172-177.
13. Johnston, A. W. B. (2004). Mechanisms and regulation of iron uptake in the rhizobia. In Iron Transport in Bacteria, pp. 469-488. Edited by J. H. Crosa, A. R. Mey & S. M. Payne. Washington, DC: American Society for Microbiology.
14. Massé E. & Gottesman, S. (2002). A small RNA regulates the expression of genes involved in iron metabolism in Escherichia coli. Proc Natl Acad Sci U S A 99, 4520-4625.
15. Park, S. Y., Kelminson, K. L., Lee, A. K., Zhang, P., Warner, R. E., Rehkopf, D. H., Calderwood, S. B. & Koehler, J. E. (2001). Identification, characterization, and functional analysis of a gene encoding the ferric uptake regulation protein in Bartonella species. J Bacteriol 183, 5751-5755.
16. Platero, R., Peixoto, L., O'Brian, M. R. & Fabiano, E. (2004). Fur is involved in manganese-dependent regulation of mntA (sitA) expression in Sinorhizobium meliloti. Appl Environ Microbiol 70, 4349-4355.
17. Pohl, E., Haller, J. C., Mijovilovich, A., Meyer-Klaucke, W., Garman, E. & Vasil, M. L. (2003). Architecture of a protein central to iron homeostasis: crystal structure and spectroscopic analysis of the ferric uptake regulator. Mol Microbiol 47, 903-915.
18. Rossen, L., Shearman, C. A., Johnston, A. W. B. & Downie, J. A. (1985). The nodD gene of Rhizobium leguminosarum is autoregulatory and in the presence of plant root exudate induces the nodABC genes. EMBO J 4, 3369-3374.
19. Sawers, G. & Böck, A. (1989). Novel transcriptional control of the pyruvate formate-lyase gene: upstream regulatory sequences and multiple promoters regulate anaerobic expression. J Bacteriol 171, 2485-2498.
20. Spaink, H. P., Okker, R. J. H., Wijffelman, C. A., Peas, E. & Lugtenberg, B. J. J. (1987). Promoters in the nodulation region of the Rhizobium leguminosarum symbiotic plasmid pRL1JI. Plant Mol Biol 9, 27-39.
21. Todd, J. D., Wexler, M., Sawers, G., Yeoman, K. H., Poole, P. S. & Johnston, A. W. B. (2002). RirA, an iron-responsive regulator in the symbiotic bacterium Rhizobium leguminosarum. Microbiology 148, 4059-4071.
22. Todd, J. D., Sawers, G. & Johnston, A. W. (2005). Proteomic analysis reveals the wide-ranging effects of the novel, iron-responsive regulator RirA in Rhizobium leguminosarum bv. viciae. Mol Genet Genomics 273, 197-206.
23. Tucker, N. P., D'Autreaux, B., Studholme, D. J., Spiro, S. & Dixon, R. (2004). DNA binding activity of the Escherichia coli nitric oxide sensor NorR suggests a conserved target sequence in diverse proteobacteria. J Bacteriol 186, 6656-6660.
24. Viguier, C. O., Cuiv, P., Clarke, P. & O'Connell, M. (2005). RirA is the iron response regulator of the rhizobactin 1021 biosynthesis and transport genes in Sinorhizobium meliloti 2011. FEMS Microbiol Lett 246, 235-242.
25. Wexler, M., Yeoman, K. H., Stevens, J. B., de Luca, N. G., Sawers, G. & Johnston, A. W. B. (2001). The Rhizobium leguminosarum tonB gene is required for the uptake of siderophore and haem as sources of iron. Mol Microbiol 41, 801-816.
26. Wexler, M., Todd, J. D., Kolade, O., Bellini, D., Hemmings, A. M., Sawers, G. & Johnston, A. W. B. (2003). Fur is not the global regulator of iron uptake genes in Rhizobium leguminosarum. Microbiology 149, 1357-1365.
27. Wood, W. B. (1966). Host specificity of DNA produced by Escherichia coli; bacterial mutations affecting the restriction and modification of DNA. Mol Biol 16, 118-133.