DNA binding activity of the Escherichia coli nitric oxide sensor NorR suggests a conserved target sequence in diverse proteobacteria

Journal of Bacteriology

Volumn 186, Issue 19, 2004, Pages 6656-6660

  Tucker, Nicholas P ^a   D'Autréaux, Benoît ^a   Studholme, David J ^b   Spiro, Stephen ^c   Dixon, Ray ^a  

^a JOHN INNES CENTRE   (United Kingdom)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^c GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; NITRIC OXIDE; PROTEIN NORR; SPACER DNA; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DNA BINDING; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING;

AMINO ACID SEQUENCE; BINDING SITES; CONSERVED SEQUENCE; DNA; ESCHERICHIA COLI PROTEINS; MOLECULAR SEQUENCE DATA; NITRIC OXIDE; PROTEOBACTERIA; TRANS-ACTIVATORS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA; PROTEOBACTERIA;

EID: 4544366542     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.186.19.6656-6660.2004     Document Type: Article

References (26)

1. Austin, S., M. Buck, W. Cannon, T. Eydmann, and R. Dixon. 1994. Purification and in vitro activities of the native nitrogen fixation control proteins NIFA and NIFL. J. Bacteriol. 176:3460-3465.
2. Buck, M., and W. Cannon. 1992. Specific binding of the transcription factor sigma-54 to promoter DNA. Nature 358:422-424.
3. Cruz-Ramos, H., J. Crack, G. Wu, M. N. Hughes, C. Scott, A. J. Thomson, J. Green, and R. K. Poole. 2002. NO sensing by FNR: regulation of the Escherichia coli NO-detoxifying flavohaemoglobin, Hmp. EMBO J. 21:3235-3244.
4. Da Costa, P. N., M. Teixeira, and L. M. Saraiva. 2003. Regulation of the flavorubredoxin nitric oxide reductase gene in Escherichia coli: nitrate repression, nitrite induction, and possible post-transcription control. FEMS Microbiol. Lett. 218:385-393.
5. D'Autréaux, B., D. Touati, B. Bersch, J.-M. Latour, and I. Michaud-Soret. 2002. Direct inhibition by nitric oxide of the transcriptional ferric uptake regulation protein via nitrosylation of the iron. Proc. Natl. Acad. Sci. USA 99:16619-16624.
6. Ding, H., and B. Demple. 2000. Direct nitric oxide signal transduction via nitrosylation of iron-sulfur centers in the SoxR transcription activator. Proc. Natl. Acad. Sci. USA 97:5146-5150.
7. Eriksson, S., S. Lucchini, A. Thompson, M. Rhen, and J. C. Hinton. 2003. Unravelling the biology of macrophage infection by gene expression profiling of intracellular Salmonella enterica. Mol. Microbiol. 47:103-118.
8. Farez-Vidal, M., T. Wilson, B. Davidson, G. Howlett, S. Austin, and R. Dixon. 1996. Effector-induced self-association and conformational changes in the enhancer-binding protein NTRC. Mol. Microbiol. 22:779-788.
9. Gardner, A. M., and P. R. Gardner. 2002. Flavohemoglobin detoxifies nitric oxide in aerobic, but not anaerobic, Escherichia colL Evidence for a novel inducible anaerobic nitric oxide-scavenging activity. J. Biol. Chem. 277:8166-8171.
10. 54 in the nitric oxide stress response. J. Biol. Chem. 278:10081-10086.
11. Gardner, A. M., R. A. Helmick, and P. R. Gardner. 2002. Flavorubredoxin, an inducible catalyst for nitric oxide reduction and detoxification in Escherichia coli. J. Biol. Chem. 277:8172-8177.
12. Gerstel, U., C. Park, and U. Römling. 2003. Complex regulation of csgD promoter activity by global regulatory proteins. Mol. Microbiol. 49:639-654.
13. Gomes, C. M., A. Giuffre, E. Forte, J. B. Vicente, L. M. Saraiva, M. Brunori, and M. Teixeira. 2002. A novel type of nitric-oxide reductase, Escherichia coli flavorubredoxin. J. Biol. Chem. 277:25273-25276.
14. Hoover, T. R., E. Santero, S. Porter, and S. Kustu. 1990. The integration host factor stimulates interaction of RNA polymerase with NIFA, the transcriptional activator for nitrogen fixation operons. Cell 63:11-22.
15. Hutchings, M. I., N. Mandhana, and S. Spiro. 2002. The NorR protein of Escherichia coli activates expression of the flavorubredoxin gene norV in response to reactive nitrogen species. J. Bacteriol. 184:4640-4643.
16. Kim, S. O., K. Merchant, R. Nudelman, W. F. Beyer, Jr., T. Keng, J. DeAngelo, A. Hausladen, and J. S. Stamler. 2002. OxyR: a molecular code for redox-related signaling. Cell 109:383-896.
17. Moore, L. J., and P. J. Kiley. 2001. Characterization of the dimerization domain in the FNR transcription factor. J. Biol. Chem. 276:45744-45750.
18. Morett, E., and M. Buck. 1989. In vivo studies on the interaction of RNA polymerase-σ54 with the Klebsiella pneumoniae and Rhizobium meliloti nifH promoters: the role of NifA in the formation of an open promoter complex. J. Mol. Biol. 210:65-77.
19. Mukhopadhyay, P., M. Zheng, L. A. Bedzyk, R. A. LaRossa, and G. Storz. 2004. Prominent roles of the NorR and Fur regulators in the Escherichia coli transcriptional response to reactive nitrogen species. Proc. Natl. Acad. Sci. USA 101:745-750.
20. Pohlmann, A., R. Cramm, K. Schmelz, and B. Friedrich. 2000. A novel NO-responding regulator controls the reduction of nitric oxide in Ralstonia eutropha. Mol. Microbiol. 38:626-638.
21. Porter, S., A. North, A. Wedel, and S. Kustu. 1993. Oligomerization of NTRC at the glnA enhancer is required for transcriptional activation. Gen. Dev. 7:2258-2273.
22. Ramseier, T. M., R. M. Figge, and M. H. Saier, Jr. 1994. DNA sequence of a gene in Escherichia coli encoding a putative tripartite transcription factor with receiver, ATPase and DNA binding domains. DNA Seq. 5:17-24.
23. Rhodius, V. A., and R. A. LaRossa. 2003. Uses and pitfalls of microarrays for studying transcriptional regulation. Curr. Opin. Microbiol. 6:114-119.
24. Santero, E., T. R. Hoover, A. K. North, D. K. Berger, S. C. Porter, and S. Kustu. 1992. Role of integration host factor in stimulating transcription from the sigma 54-dependent nifH promoter. J. Mol. Biol. 227:602-620.
25. Studholme, D. J., and R. Dixon. 2003. Domain architectures of sigma54-dependent transcriptional activators. J. Bacteriol. 185:1757-1767.
26. Widdick, D., E. Farez Vidal, S. Austin, and R. Dixon. 1998. Properties of a mutant form of the prokaryotic enhancer binding protein, NTRC, which hydrolyses ATP in the absence of effectors. FEBS Lett. 437:70-74.