The use of ciliary neurotrophic factor to promote recovery after peripheral nerve injury by delivering it at the site of the cell body

Acta Neurochirurgica

Volumn 148, Issue 1, 2006, Pages 55-60

  Kelleher, M O ^a   Myles, L M ^b   Al Abri, R K ^b   Glasby, M A ^b  

^a BEAUMONT HOSPITAL   (Ireland)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

CNTF; Intrathecal; Nerve repair; Neurotrophic factors

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; SODIUM CHLORIDE;

AMPLITUDE MODULATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CEREBROSPINAL FLUID; COMPARATIVE STUDY; CONTROLLED STUDY; ELECTROPHYSIOLOGY; IMPLANT; MEDIAN NERVE; MORPHOLOGY; MORPHOMETRICS; MUSCLE ISOMETRIC CONTRACTION; MUSCLE MASS; NERVE FIBER; NERVE FIBER REGENERATION; NONHUMAN; OSMOTIC PUMP; PERIKARYON; PERIPHERAL NERVE INJURY; PHYSIOLOGY; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; SHEEP; STATISTICAL SIGNIFICANCE; SUTURING METHOD; TETANUS; THICKNESS;

ANIMALS; CEREBROSPINAL FLUID; CERVICAL VERTEBRAE; CILIARY NEUROTROPHIC FACTOR; INFUSION PUMPS, IMPLANTABLE; INFUSIONS, INTRALESIONAL; MEDIAN NERVE; NERVE REGENERATION; NEURAL CONDUCTION; SHEEP;

EID: 29244468254     PISSN: 00016268     EISSN: 09420940     Source Type: Journal    
DOI: 10.1007/s00701-005-0631-2     Document Type: Article

References (27)

1. M Manthorpe S Skaper R Adler K Landa S Varon 1980 Cholinergic neuronotrophic factors: fractionation properties of an extract from selected chick embryonic eye tissues. J Neurochem 34 69 75
2. M Sendtner P Carroll B Holtmann RA Hughes H Thoenen 1994 Ciliary neurotrophic factor. J Neurobiol 25 1436 1453
3. RW Oppenheim D Prevette QW Yin F Collins J [tmp] MacDonald 1991 Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factor. Science 251 1616 1618
4. L Li RW Oppenheim M Lei LJ Houenou 1994 Neurotrophic agents prevent motoneuron death following sciatic nerve section in the neonatal mouse. J Neurobiol 25 759 766
5. M Sendtner GW Kreutzberg H Thoenen 1997 Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy. Nature 345 440 441
6. YW Kwon ME Gurney 1994 Systemic injections of ciliary neurotrophic factor induce sprouting by adult motor neurons. NeuroReport 5 789 792
7. ME Gurney H Yamamoto Y Kwon 1992 Induction of motor neuron sprouting in vivo by ciliary neurotrophic factor and basic fibroblast growth factor. J Neurosci 12 3241 3247
8. SL Lewin DS Utley ET Cheng AN Verity DJ Terris 1997 Simultaneous treatment with BDNF and CNTF after peripheral nerve transection and repair enhances rate of functional recovery compared with BDNF treatment alone. Laryngoscope 107 992 999
9. Z Sahenk J Seharaseyon JR Mendell 1994 CNTF potentiates peripheral nerve regeneration. Brain Res 655 246 250
10. F Dittrich H Thoenen M Sendtner 1994 Ciliary neurotrophic factor: pharmacokinetics and acute-phase response in rat. Ann Neurol 35 151 163
11. R Curtis KM Adryan Y Zhu PJ Harkness RM Lindsay PS DiStefano 1994 Retrograde anonal transport of ciliary neurotrophic factor is increased by peripheral nerve injury. Nature 365 253 255
12. DV Lenihan NM Sojitra M Ikeda AC Carter MA Glasby 1997 Stimulated jitter measurement in the assessment of recovery after peripheral nerve repair. J Hand Surg 22B 772 777
13. DV Lenihan NM Sojitra MA Glasby 1998 Stimulated jitter measurement in the assessment of recovery after different methods of peripheral nerve repair. J Hand Surg - Brit Vol 23B 12 16
14. KL [tmp] McDowall DV Lenihan A Busuttil MA Glasby 1998 The use of absolute refractory period in the estimation of early postmortem interval. Forensic Sci Int 91 163 170
15. Delisa J, Lee H, Baran E, Lai K, Spielholz N, MacKenzie K (1994) Manual of nerve conduction velocity and clinical neurophysiology. Raven Press, New York
16. Mayhew TM (1990) Efficient and unbiased sampling of nerve fibres for estimating fibre number and size. In: Conn PM (ed) Methods in neurosciences. Academic Press, London, pp 172-187
17. Kirkwood BR (1991) Comparison of several means - analysis of variance. In: Kirkwood BR (ed) Essentials of medical statistics. Blackwell Scientific Publications, Oxford, pp 46-55
18. AC Fullarton DV Lenihan LM Myles MA Glasby 2000 Obstetric brachial plexus palsy: a large animal model for traction injury and its repair. Part I age of the recipient. J Hand Surg 25B 52 57
19. A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis (1996) ALS CNTF Treatment Study Group. Neurology 46: 1244-1249
20. MW Sleeman KD Anderson PD Lambert GD Yancopoulos SJ Wiegand 2000 The ciliary neurotrophic factor and its receptor, CNTFR alpha. Pharm Acta Helv 74 265 272
21. RG Miller JH Petajan WW Bryan C Armon RJ Barohn JC Goodpasture RJ Hoagland GJ Parry MA Ross SC Stromatt 1996 A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. rhCNTF ALS Study Group. Ann Neurol 39 256 260
22. Kimura J (2001) Electrodiagnosis in diseases of nerve and muscle. F.A.Davis, Philadelphia
23. Kelly G (2002) The effects of neurotrophic factors in facial nerve repair. Ref type: Thesis/Dissertation
24. JT Aitken M Sharman JZ Young 1947 Maturation of regenerating nerve fibres with various peripheral connexions. J Anat 81 1 23
25. ME Peroulakis NG Forger 2000 Ciliary neurotrophic factor increases muscle fiber number in the developing levator ani muscle of female rats. Neurosci Lett 296 73 76
26. RD Penn JS Kroin MM York JM Cedarbaum 1997 Intrathecal ciliary neurotrophic factor delivery for treatment of amyotrophic lateral sclerosis (phase I trial). Neurosurgery 40 94 99
27. G Terenghi 1999 Peripheral nerve regeneration and neurotrophic factors. J Anat 194 Pt 1 1 14