Role of HSPs and telomerase in radiotherapy

International Journal of Hyperthermia

Volumn 21, Issue 8, 2005, Pages 689-694

  Pandita, Tej K ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

HSP70; HSP90; Telomerase; Telomeres

Indexed keywords

CHAPERONE; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; TELOMERASE;

CANCER INHIBITION; CANCER RADIOTHERAPY; CANCER THERAPY; CATALYSIS; CHROMOSOMAL INSTABILITY; CONFERENCE PAPER; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; IONIZING RADIATION; NONHUMAN; PROTEIN INTERACTION; SOMATIC CELL; TELOMERE; TREATMENT FAILURE; TUMOR CELL; TUMOR GROWTH;

ANIMALS; CELL LINE; DNA REPAIR; HSP70 HEAT-SHOCK PROTEINS; HUMANS; NEOPLASMS; RADIOTHERAPY; TELOMERASE;

EID: 29144523099     PISSN: 02656736     EISSN: 14645157     Source Type: Journal    
DOI: 10.1080/02656730500271700     Document Type: Conference Paper

References (27)

1. Hunt C, Moritmoto RI. Conserved features of eukaryotic HSP70 genes revealed by comparison with the nucleotide sequence of human HSP70. Proceedings of the National Academy of Sciences (USA) 1985;82:6455-6459.
2. Luft JC, Benjamin IJ, Mestril R, Dix DJ. Heat shock factor 1-mediated thermotolerance prevents cell death and results in G2/M cell cycle arrest. Cell Stress Chaperones 2001;6:326-336.
3. Sarge KD, Cullen KE. Regulation of hsp expression during rodent spermatogenesis. Cell & Molecular Life Science 1997;53:191-197.
4. Bukau B, Deuerling E, Pfund C, Craig EA. Getting newly synthesized proteins into shape. Cell 2000;101:119-122.
5. Georgopoulos C, Welch WJ. Role of the major heat shock proteins as molecular chaperones. Annual Review of Cell Biology 1993;9:601-634.
6. Hartl FU. Molecular chaperones in cellular protein folding. Nature 1996;381:571-579.
7. Kenny MK, Mendez F, Sandigursky M, Kureekattil RP, Goldman JD, Franklin WA, Bases R. Heat shock protein 70 binds to human apurinic/apyrimidinic endonuclease and stimulates endonuclease activity at abasic sites. Journal of Biological Chemistry 2001;276:9532-9536.
8. Brondani Da Rocha A, Regner A, Grivicich I, Pretto Schunemann D, Diel C, Kovaleski G, Brunetto De Farias C, Mondadori E, Almeida L, Braga Filho A, Schwartsmann G. Radioresistance is associated to increased Hsp70 content in human glioblastoma cell lines. International Journal of Oncology 2004;25:777-785.
9. Hunt CR, Dix DJ, Sharma GG, Pandita RK, Gupta A, Funk M, Pandita TK. Genomic instability and enhanced radiosensitivity in Hsp70.1- and Hsp70.3-deficient mice. Molecular Cellular Biology 2004;24:899-911.
10. Hand JW, Walker H, Hornsey S, Field SB. Effects of hyperthermia on the mouse testis and its response to X-rays, as assayed by weight loss. International Journal of Radiation Biology 1979;35:521-528.
11. Huang L, Mivechi NF, Moskophidis D. Insights into regulation and function of the major stress-induced hsp70 molecular chaperone in vivo: Analysis of mice with targeted gene disruption of the hsp70.1 or hsp70.3 gene. Molecular Cellular Biology 2001;21:8575-8591.
12. Hunt C, Calderwood S. Characterization and sequence of a mouse hsp70 gene and its expression in mouse cell lines. Gene 1990;87:199-204.
13. Pandita TK, Hall EJ, Hei TK, Piatyszek MA, Wright WE, Piao CQ, Pandita RK, Willey JC, Geard CR, Kastan MB, Shay JW. Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles simulating radon progeny. Oncogene 1996;13:1423-1430.
14. Pandita TK. ATM function and telomere stability. Oncogene 2002;21:611-618.
15. Wood LD, Halvorsen TL, Dhar S, Baur JA, Pandita RK, Wright WE, Hande MP, Calaf G, Hei TK, Levine F, Shay JW, Wang JJ, Pandita TK. Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression. Oncogene 2001;20:278-288.
16. Pandita TK. Telomeres and telomerase. Encyclopedia of Cancer 2002;4:355-362.
17. Holt SE, Aisner DL, Baur J, et al. Functional requirement of p23 and HSP90 in telomerase complexes. Genes Development 1999;13:817-826.
18. Kim JH, Park SM, Kang MR, Oh SY, Lee TH, Muller MT, Chung IK. Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT. Genes Development 2005;19:776-781.
19. Barker K, Khayat M, Miller N, et al. Immortal and mortal clonal lymphocyte lines from channel catfish: Comparison of telomere length, telomerase activity, tumor suppressor and heat shock protein expression. Development and Computations in Immunology 2002;26:45-51.
20. Martinez JL, Sanchez-Elsner T, Morcillo G, Diez JL. Heat shock regulatory elements are present in telomeric repeats of Chironomous thummi. Nucleic Acids Research 2001;29:4760-4766.
21. Forsythe HL, Jarvis JL, Turner JW, et al. Stable association of hsp90 and p23, but not hsp70, with active human telomerase. Journal of Biological Chemistry 2001;276:15571-15574.
22. Sharma GG, Gupta A, Wang H, Scherthan H, Dhar S, Gandhi V, Iliakis G, Shay JW, Young CS, Pandita TK. hTERT associates with human telomeres and enhances genomic stability and DNA repair. Oncogene 2003;22:131-146.
23. Kim NW, Piatyszek ME, Prowse KR, Harley CD, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW. Specific association of human telomerase activity with immortal cells and cancer. Science 1994;266:2011-2015.
24. Sun D, Lopez-Guajardo CC, Quada J, Hurley LH, Von Hoff DD. Regulation of catalytic activity and processivity of humantelomerase. Biochemistry 1999;38:4037-4044.
25. Herbert B, Pitts AE, Baker SI, Hamilton SE, Wright WE, Shay JW, Corey DR. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proceedings of the National Academy of Sciences (USA) 1999;96:14276-14281.
26. Elayadi AN, Braasch DA, Corey DR. Implications of high-affinity hybridization by locked nucleic acid oligomers for inhibition of human telomerase. Biochemistry 2002;41:9973-9981.
27. Pandita TK, RotiRoti JL. Telomerase activity and radiocurablity. Oncology Reports 2003;10:263-270.