Different pharmacokinetics of tramadol in mothers treated for labour pain and in their neonates: Towards an increased knowledge of paediatric clinical pharmacology

European Journal of Clinical Pharmacology

Volumn 61, Issue 12, 2005, Pages 929-930

  Johnson, Trevor N ^a  

^a SHEFFIELD CHILDREN S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; CYTOCHROME P450 3A7; DEXTROMETHORPHAN; DRUG METABOLITE; O NORTRAMADOL; TRAMADOL; UNCLASSIFIED DRUG;

DEMETHYLATION; DRUG EFFECT; DRUG HALF LIFE; DRUG PENETRATION; GLOMERULUS FILTRATION RATE; HUMAN; LABOR PAIN; LETTER; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCIENTIFIC LITERATURE;

ANALGESICS, OPIOID; FEMALE; HUMANS; INFANT, NEWBORN; LABOR PAIN; METABOLIC CLEARANCE RATE; PEDIATRICS; PREGNANCY; TRAMADOL;

EID: 29144516219     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-005-0030-x     Document Type: Letter

References (15)

1. Claahsen-Van Der Grillten HL, Verbruggen I, Van Den Berg PP, Sporken JM, Kollee LA (2005) Different pharmacokinetics of tramadol in mothers treated for labour pain and in their neonates. Eur J Clin Pharmacol 61(7):523-529
2. Tateishi T, Nakura H, Asoh M, Watanabe M, Tanaka M, Kumai T, Takashima S, Imaoka S, Funae Y, Yabusaki Y, Kamataki T, Kobayashi S (1997) A comparison of hepatic cytochrome P450 protein expression between infancy and post-infancy. Life Sci 61:2567-2574
3. Treluyer JM, Jacqz-Aigrain E, Alvarez F, Cresteil T (1991) Expression of CYP2D6 in developing human liver. Eur J Biochem 202:583-588
4. Leeder JS, Gotschall RR, Gaedigk A, Adcock K, Wilson JT, Kearns GL (2000) Acquisition of functional CYP2D6 and CYP3A4 activities in vivo in the first year of life. Drug Metab Rev 32 (Suppl2):281
5. Allegaert K, Anderson BJ, Verbesselt R, Debeer A, De Hoon J, Devlieger H, Van Den Anker JN, Tibboel D (2005) Tramadol disposition in the very young: an attempt to assess in vivo cytochrome P-450 2D6 activity. Br J Anaesth 95:231-239
6. Abdel-Rahman SM, Leeder JS, Wilson JT, Gaedigk A, Gotschall RR, Medve R, Liao S, Spielberg SP, Kearns GL (2002) Concordance between tramadol and dextromethorphan parent/ metabolite ratios: the influence of CYP2D6 and non-CYP2D6 pathways on biotransformation. J Clin Pharmacol 42:24-29
7. Subrahmanyam V, Renwick AB, Walters DG, Young PJ, Price RJ, Tonelli AP, Lake BG (2001) Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes. Drug Metab Dispos 29:1146-1155
8. Alcorn J, Mcnamara PJ (2002) Ontogeny of hepatic and renal systemic clearance pathways in infants: part I. Clin Pharmacokinet 41:959-998
9. Lacroix D, Sonnier M, Moncion A, Cheron G, Cresteil T (1997) Expression of CYP3A in the human liver - evidence that the shift between CYP3A7 and CYP3A4 occurs immediately after birth. Eur J Biochem 247:625-634
10. Stevens JC, Hines RN, Gu C, Koukouritaki SB, Manro JR, Tandler PJ, Zaya MJ (2003) Developmental expression of the major human hepatic CYP3A enzymes. J Pharmacol Exp Ther 307:573-582
11. De Wildt SN, Kearns GL, Leeder JS, Van Den Anker JN (1999) Cytochrome P450 3A: ontogeny and drug disposition. Clin Pharmacokinet 37:485-505
12. Koukouritaki SB, Manro JR, Marsh SA, Stevens JC, Rettie AE, Mccarver DG, Hines RN (2004) Developmental expression of human hepatic CYP2C9 and CYP2C19. J Pharmacol Exp Ther 308:965-974
13. Hayton W (2002) Maturation and growth of renal function: dosing renally cleared drugs in children. AAPS Pharm Sci 2:1-7
14. Mccarver DG, Hines RN (2002) The ontogeny of human drug-metabolizing enzymes: phase II conjugation enzymes and regulatory mechanisms. J Pharmacol Exp Ther 300:361-366
15. Saint-Raymond A, Seigneuret N (2005) Medicines for children: time for Europe to act. Paed Perinat Drug Ther 6:142-146