CYTOCHROME P450;
DRUG CARRIER;
GLYCOPROTEIN P INHIBITOR;
PROTEIN;
APICAL MEMBRANE;
BASEMENT MEMBRANE;
BINDING AFFINITY;
BIOINFORMATICS;
CELL MEMBRANE;
CELL STRAIN CACO 2;
DRUG ABSORPTION;
DRUG BIOAVAILABILITY;
DRUG DELIVERY SYSTEM;
DRUG DISPOSITION;
DRUG DISTRIBUTION;
DRUG EFFICACY;
DRUG ELIMINATION;
DRUG INDUSTRY;
DRUG METABOLISM;
DRUG SAFETY;
DRUG SCREENING;
DRUG SOLUBILITY;
DRUG STABILITY;
DRUG TARGETING;
DRUG TRANSPORT;
EDITORIAL;
ENZYME INHIBITION;
ENZYME METABOLISM;
EPITHELIUM CELL;
GENE FUNCTION;
GENETIC TRANSFECTION;
GENOME;
HEALTH PROGRAM;
HUMAN;
IN VITRO STUDY;
IN VIVO STUDY;
INTESTINE ABSORPTION;
INTESTINE FUNCTION;
KIDNEY FUNCTION;
LIVER FUNCTION;
LIVER MICROSOME;
MEDICAL INFORMATION;
MOLECULAR BIOLOGY;
MOLECULAR INTERACTION;
PHYSICAL CHEMISTRY;
PREDICTION;
TISSUE DISTRIBUTION;
TOXICITY;
TOXICOLOGY;
BIOLOGICAL TRANSPORT;
DRUG DESIGN;
GENOME;
PHARMACEUTICAL PREPARATIONS;
PHARMACOKINETICS;
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
C.A. Lipinski Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Adv. Drug Deliv. Rev. 46 2001 3 26
K. Giacomini, Y. Sugiyama Membrane transporters and drug response L.L. Brunton Goodman & Gilman's, the pharmacological basis of therapeutics 11th edn. 2005 McGraw-Hill 41 70
Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and multidrug resistance-associated protein 2 (MRP2/ABCC2)
M. Sasaki Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and multidrug resistance-associated protein 2 (MRP2/ABCC2) J. Biol. Chem. 277 2002 6497 6503
Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2
Y. Cui Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2 Mol. Pharmacol. 60 2001 934 943
The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules
T. Imaoka The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules J. Am. Soc. Nephrol. 15 2004 2012 2022
A comprehensive strategy for ADME screening in drug discovery
R.T. Borchardt AAPS press *et al.
R.E. White A comprehensive strategy for ADME screening in drug discovery R.T. Borchardt Pharmaceutical profiling in drug discovery for lead selection 2004 AAPS press 431 450
Prediction of hepatic clearance in humans from experimental animals and in vitro data
M.B. Fisher Fontis Media and Marcel Dekker *et al.
M. Chiba Prediction of hepatic clearance in humans from experimental animals and in vitro data M.B. Fisher drug metabolizing enzymes: cytochrome P450 and other enzymes in drug discovery and development 2003 Fontis Media and Marcel Dekker 453 481
