LIM-domain-binding protein 1: A multifunctional cofactor that interacts with diverse proteins

EMBO Reports

Volumn 4, Issue 12, 2003, Pages 1132-1137

  Matthews, Jacqueline M ^a   Visvader, Jane E ^b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b Bone Marrow Research Laboratories   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; BINDING PROTEIN; HOMEODOMAIN PROTEIN; LIM DOMAIN BINDING PROTEIN 1; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

CELL DIFFERENTIATION; CELL FATE; CONTROLLED STUDY; DIMERIZATION; GENE TARGETING; GENETIC CONSERVATION; HUMAN; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; CELL DIFFERENTIATION; DIMERIZATION; DNA-BINDING PROTEINS; HOMEODOMAIN PROTEINS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHYLOGENY; SPECIES SPECIFICITY; TRANSCRIPTION FACTORS;

EID: 0347093483     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.embor.7400030     Document Type: Review

References (38)

1. Agulnick, A.D., Taira, M., Breen, J.J., Tanaka, T., Dawid, I.B. & Westphal, H. (1996) Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature, 384, 270-272.
2. Bach, I. (2000) The LIM domain: regulation by association. Mech. Dev., 91, 5-17.
3. Bach, I., Carriere, C., Ostendorff, H.P., Andersen, B. & Rosenfeld, M.G. (1997) A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and OTX homeodomain proteins. Genes Dev., 11, 1370-1380.
4. Becker, T., Ostendorff, H.P., Bossenz, M., Schluter, A., Becker, C.G., Peirano, R.I. & Bach, I. (2002) Multiple functions of LIM domain-binding CLIM/NLI/Ldb cofactors during zebrafish development. Mech. Dev., 117, 75-85.
5. Cassata, G., Rohrig, S., Kuhn, F., Hauri, H.P., Baumeister, R. & Burglin, T.R. (2000) The Caenorhabditis elegans Ldb/NLI/CLIM orthologue Ldb-1 is required for neuronal function. Dev. Biol., 226, 45-56.
6. Chen, L., Segal, D., Hukriede, N.A., Podtelejnikov, A.V., Bayarsaihan, D., Kennison, J.A., Ogryzko, V.V., Dawid, I.B. & Westphal, H. (2002) Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development. Proc. Natl Acad. Sci. USA, 99, 14320-14325.
7. Dawid, I.B., Breen, J.J. & Toyama, R. (1998) Lim domains: multiple roles as adapters and functional modifiers in protein interactions. Trends Genet., 14, 156-162.
8. Deane, J.E., Mackay, J.P., Kwan, A.H., Sum, E.Y., Visvader, J.E. & Matthews, J.M. (2003) Structural basis for the recognition of Ldb1 by the N-terminal LIM domains of LMO2 and LMO4. EMBO J., 22, 2224-2233.
9. Fernandez-Funez, P., Lu, C.H., Rincon-Limas, D.E., Garcia-Bellido, A. & Botas, J. (1998) The relative expression amounts of apterous and its co-factor dLdb/Chip are critical for dorso-ventral compartmentalization in the Drosophila wing. EMBO J., 17, 6846-6853.
10. Gause, M., Morcillo, P. & Dorsett, D. (2001) Insulation of enhancer-promoter communication by a gypsy transposon insert in the Drosophila cut gene: cooperation between suppressor of hairy-wing and modifier of mdg4 proteins. Mol. Cell. Biol., 21, 4807-4817.
11. German, M.S., Wang, J., Chadwick, R.B. & Rutter, W.J. (1992) Synergistic activation of the insulin gene by a LIM-homeodomain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex. Genes Dev, 6, 2165-2176.
12. Gupta, B.P., Wang, M. & Sternberg, P.W. (2003) The C. elegans LIM homeobox gene lin-11 specifies multiple cell fates during vulval development. Development, 130, 2589-2601.
13. Heitzler, P., Vanolst, L., Biryukova, I. & Ramain, P. (2003) Enhancer-promoter communication mediated by Chip during Pannier-driven proneural patterning is regulated by OSA. Genes Dev., 17, 591-596.
14. Hobert, O. & Westphal, H. (2000) Functions of LIM-homeobox genes. Trends Genet., 16, 75-83.
15. Jurata, L.W. & Gill, G.N. (1997) Functional analysis of the nuclear LIM domain interactor NLI. Mol. Cell. Biol., 17, 5688-5698.
16. Jurata, L.W., Kenny, D.A. & Gill, G.N. (1996) Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development. Proc. Natl Acad. Sci. USA, 93, 11693-11698.
17. Jurata, L.W., Pfaff, S.L. & Gill, G.N. (1998) The nuclear LIM domain interactor NLI mediates home- and heterodimerization of lim domain transcription factors. J. Biol. Chem., 273, 3152-3157.
18. Milan, M. & Cohen, S.M. (1999) Regulation of LIM homeodomain activity in vivo: a tetramer of dLdb and apterous confers activity and capacity for regulation by dLMO. Mol. Cell, 4, 267-273.
19. Milan, M., Diaz-Benjumea, F.J. & Cohen, S.M. (1998) Beadex encodes an LMO protein that regulates apterous LIM-homeodomain activity in Drosophila wing development: a model for LMO oncogene function. Genes Dev, 12, 2912-2920.
20. Mizunuma, H., Miyazawa, J., Sanada, K. & Imai, K. (2003) The LIM-only protein, LMO4, and the LIM domain-binding protein, Ldb1, expression in squamous cell carcinomas of the oral cavity. Br. J. Cancer, 88, 1543-1548.
21. Mochizuki, T. et al. (2000) Xlim-1 and LIM domain binding protein 1 cooperate with various transcription factors in the regulation of the goosecoid promoter. Dev. Biol., 224, 470-485.
22. Morcillo, P., Rosen, C. & Dorsett, D. (1996) Genes regulating the remote wing margin enhancer in the Drosophila cut locus. Genetics, 144, 1143-1154.
23. Morcillo, P., Rosen, C., Baylies, M.K. & Dorsett, D. (1997) Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila. Genes Dev., 11, 2729-2740.
24. Mukhopadhyay, M. et al. (2003) Functional ablation of the mouse Ldb 1 gene results in severe patterning defects during gastrulation. Development, 130, 495-505.
25. Ostendorff, H.P., Peirano, R.I., Peters, M.A., Schluter, A., Bossenz, M., Scheffner, M. & Bach, I. (2002) Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. Nature, 416, 99-103.
26. Rabbitts T.H. (1998) LMOT-cell translocation oncogenes typify genes activated by chromosomal translocations that alter transcription and developmental processes. Genes Dev., 12, 2651-2657.
27. Ramain, P., Khechumian, R., Khechumian, K., Arbogast, N., Ackermann, C. & Heitzler, P. (2000) Interactions between Chip and the Achaete/Scute-Daughterless heterodimers are required for Pannier-driven proneural patterning. Mol. Cell, 6, 781-790.
28. Rincon-Limas, D.E., Lu, C.H., Canal, I. & Botas, J. (2000) The level of dLdb/Chip controls the activity of the LIM homeodomain protein Apterous: evidence for a functional tetramer complex in vivo. EMBO J., 19, 2602-2614.
29. Sanchez-Garcia, I., Osada, H., Forster, A. & Rabbitts, T.H. (1993) The cysteine-rich LIM domains inhibit DNA binding by the associated homeodomain in Isl-1. EMBO J., 12, 4243-4250.
30. Shoresh, M., Orgad, S., Shmueli, O., Werczberger, R., Gelbaum, D., Abiri, S. & Segal, D. (1998) Overexpression Beadex mutations and loss-of-function heldup-a mutations in Drosophila affect the 3πm regulatory and coding components, respectively, of the dLMO gene. Genetics, 150, 283-299.
31. Thaler, J.P. et al. (2002) LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions. Cell, 110, 237-249.
32. Torigoi, E., Bennani-Baiti, I.M., Rosen, C., Gonzalez, K., Morcillo, P., Ptashne, M. & Dorsett, D. (2000) Chip interacts with diverse homeodomain proteins and potentiates bicoid activity in vivo. Proc. Natl Acad. Sci. USA, 97, 2686-2691.
33. Valge-Archer, V., Forster, A. & Rabbitts, T.H. (1998) The LMO1 and Ldb1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(pl5;q11). Oncogene, 17, 3199-3202.
34. van Meyel, D.J., O'Keefe, D.D., Thor, S., Jurata, L.W., Gill, G.N. & Thomas, J.B. (2000) Chip is an essential cofactor for apterous in the regulation of axon guidance in Drosophila. Development, 127, 1823-1831.
35. van Meyel, D.J., Thomas, J.B. & Agulnick, A.D. (2003) Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo. Development, 130, 1915-1925.
36. Visvader, J.E., Mao, X., Fujiwara, Y., Hahm, K. & Orkin, S.H. (1997) The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. Proc. Natl Acad. Sci. USA, 94, 13707-13712.
37. Visvader, J.E. et al. (2001) The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer. Proc. Natl Acad. Sci. USA, 98, 14452-14457.
38. Zeng, C., Justice, N.J., Abdelilah, S., Chan, Y.M., Jan, L.Y. & Jan, Y.N. (1998) The Drosophila LIM-only gene, dLMO, is mutated in Beadex alleles and might represent an evolutionarily conserved function in appendage development. Proc. Natl Acad. Sci. USA, 95, 10637-10642.