Different stereochemical requirements for CXCR4 binding and signaling functions as revealed by an anti-HIV, D-amino acid-containing SMM-chemokine ligand

Journal of Medicinal Chemistry

Volumn 48, Issue 25, 2005, Pages 7923-7924

  Dong, Chang Zhi ^a   Kumar, Santosh ^a   Choi, Won Tak ^a   Madani, Navid ^b   Tian, Shaomin ^a   An, Jing ^a,c   Sodroski, Joseph G ^b   Huang, Ziwei ^a,d  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Chemokine Pharmaceutical Inc   (United States)

^d BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; DEXTRO AMINO ACID; MACROPHAGE INFLAMMATORY PROTEIN 2; RCP 222; STROMAL CELL DERIVED FACTOR 1ALPHA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIVIRAL ACTIVITY; ARTICLE; CALCIUM TRANSPORT; DRUG RECEPTOR BINDING; HUMAN IMMUNODEFICIENCY VIRUS 1; PROTEIN MODIFICATION; STEREOCHEMISTRY;

AMINO ACID SEQUENCE; AMINO ACIDS; ANTI-HIV AGENTS; BINDING, COMPETITIVE; CALCIUM; CELL LINE; CHEMOKINES; CHEMOKINES, CXC; HIV-1; HUMANS; LIGANDS; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; RADIOLIGAND ASSAY; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION;

EID: 29144435997     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050829u     Document Type: Article

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