Effects of dorsomedial hypothalamic nuclei lesions on intake of an imbalanced amino acid diet

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 277, Issue 1 46-1, 1999, Pages

  Bellinger, Larry L ^a   Evans, James F ^a   Tillberg, Connie M ^a   Gietzen, Dorothy W ^b  

^a BAYLOR COLLEGE OF DENTISTRY   (United States)

^b Dept of Vet Medicine: Anatomy   (United States)

Author keywords

5 HT3; Body weight; Essential amino acid deficiency; Food intake; Rat; Serotonin receptor blockers; Serotonin receptors

Indexed keywords

TROPISETRON;

ADAPTATION; AMINO ACID DEFICIENCY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HYPOTHALAMUS LESION; HYPOTHALAMUS NUCLEUS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTAKE; RAT; WEIGHT GAIN;

EID: 0032791768     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1999.277.1.r250     Document Type: Article

References (46)

1. 3-R) in anorectic responses to a threonine imbalanced diet (Imb) (Abstract). Appetite 27: 263, 1996.
2. Bellinger, L. L. Ingestive behavior of rats with ibotenic acid lesions of the dorsomedial hypothalamus. Am. J. Physiol. 252 (Regulatory Integrative Comp. Physiol. 21): R938-R946, 1987.
3. Bellinger, L. L., and L. L. Bernardis. The effect of dorsomedial hypothalamic nuclei knife cuts on ingestive behavior. Am. J. Physiol. (In press).
4. Bellinger, L. L., L. L. Bernardis, and S. Brooks. The effect of dorsomedial hypothalamic nuclei lesions on body weight regulation. Neuroscience 4: 659-665, 1979.
5. Bellinger, L. L., T. W. Castonguay, and L. L. Bernardis. Hormone and somatic changes in rats pair-fed to growth retarded dorsomedial hypothalamic nuclei-lesioned rats. Brain Res. Bull. 34: 117-124, 1994.
6. Bellinger, L. L., J. F. Evans, and D. W. Gietzen. Dorsomedial hypothalamic lesions alter intake of an imbalanced amino acid diet in rats. J. Nutr. 128: 1213-1217, 1998.
7. Bellinger, L. L., and F. E. Williams. Aphagia and adipsia after kainic acid lesioning of the dorsomedial hypothalamic area. Am. J. Physiol. 244 (Regulatory Integrative Comp. Physiol. 13): R389-R399, 1983.
8. Bellinger, L. L., F. E. Williams, Q. R. Rogers, and D. W. Gietzen. Liver denervation attenuates the hypophagia produced by an imbalanced amino acid diet. Physiol. Behav. 59: 925-929, 1996.
9. Bernardis, L. L., and L. L. Bellinger. The dorsomedial hypothalamic nucleus revisited: 1986 update. Brain Res. Rev. 12: 321-381, 1987.
10. Beverly, J. L., D. W. Gietzen, and Q. R. Rogers. Effect of dietary limiting amino acid in prepyriform cortex on food intake. Am. J. Physiol. 259 (Regulatory Integrative Comp. Physiol. 28): R709-R715, 1990.
11. Beverly, J. L., D. W. Gietzen, and Q. R. Rogers. Effect of dietary limiting amino acid in prepyriform cortex on meal patterns. Am. J. Physiol. 259 (Regulatory Integrative Comp. Physiol. 28): R716-R723, 1990.
12. Dalton, L. D., R. G. Carpenter, and S. P. Grossman. Ingestive behavior in adult rats with dorsomedial hypothalamic lesions. Physiol. Behav. 26: 117-123, 1981.
13. Gietzen, D. W. Neural mechanisms in the responses to amino acid deficiency. J. Nutr. 123: 610-625, 1993.
14. Gietzen, D. W., L. F. Erecius, and Q. R. Rogers. Neurochemical changes after imbalanced diets suggest a brain circuit mediating anorectic responses to amino acid deficiency in rats. J. Nutr. 128: 771-781, 1998.
15. Gray, T. S., M. E. Carney, and D. J. Magnuson. Direct projections from the central amygdaloid nucleus to the hypothalamic paraventricular nucleus: possible role in stress-induced adrenocorticotropin release. Neuroendocrinology 50: 433-446, 1989.
16. 3 receptor antagonists block anorectic responses to amino acid imbalance. Am. J. Physiol. 259 (Regulatory Integrative Comp. Physiol. 28): R627-R636, 1990.
17. Hammer, V. A., D. W. Gietzen, V. D. Sworts, J. L. Beverly, and Q. R. Rogers. Adrenal hormones and the anorectic response and adaptation of rats to amino acid imbalance. J. Nutr. 120: 1617-1623, 1990.
18. Harper, A. E., N. J. Benevenga, and R. M. Wohlhueter. Effects of ingestion of disproportionate amounts of amino acids. Physiol. Rev. 50: 428-558, 1970.
19. Harper, A. E., and J. C. Peters. Protein intake, brain amino acid and serotonin concentrations and protein self-selection. J. Nutr. 119: 677-689, 1989.
20. Hrupka, B. J., D. W. Gietzen, and J. L. Beverly. ICS 205-930 and feeding responses to amino acid imbalance: a peripheral effect? Pharmacol. Biochem. Behav. 40: 83-87, 1991.
21. Hurley, K. M., H. Herbert, M. M. Moga, and C. B. Saper. Efferent projections of the infralimbic cortex of the rat. J. Comp. Neurol. 308: 249-276, 1991.
22. Konig, J. F. R., and R. A. Klippel. The Rat Brain. Huntington, NY: Kreiger, 1970.
23. Krukoff, T. L., K. H. Harris, E. Linetsky, and J. H. Jhamandas. Expression of c-fos protein in rat brain elicited by electrical and chemical stimulation of the hypothalamic paraventricular nucleus. Neuroendocrinology 59: 590-602, 1994.
24. Leung, P. M. B., and Q. R. Rogers. Importance of prepyriform cortex in food-intake response of rats to amino acids. Am. J. Physiol. 221: 929-935, 1971.
25. Leung, P. M. B., and Q. R. Rogers. Effect of amygdaloid lesions on dietary intake of disproportionate amounts of amino acids. Physiol. Behav. 11: 221-226, 1973.
26. Leung, P. M. B., Q. R. Rogers, and A. E. Harper. Effect of amino acid imbalance on dietary choice in the rat. J. Nutr. 95: 483-492, 1968.
27. Luiten, P. G. M., and P. Room. Interrelations between lateral, dorsomedial and ventromedial hypothalamic nuclei in the rat. An HRP study. Brain Res. 190: 321-332, 1980.
28. Luiten, P. G. M., G. J. ter Horst, and A. B. Steffens. The hypothalamus, intrinsic connections and outflow pathways to the endocrine system in relation to the control of feeding and metabolism. Prog. Neurobiol. 28: 1-54, 1987.
29. Luskin, M. B., and J. L. Price. The topographic organization of associational fibers of the olfactory system in the rat, including centrifugal fibers to the olfactory bulb. J. Comp. Neurol. 216: 264-291, 1983.
30. Meliza, L. L., P. M. B. Leung, and Q. R. Rogers. Effect of anterior prepyriform and medial amygdaloid lesions on acquisition of taste-avoidance and response to dietary amino acid imbalance. Physiol. Behav. 26: 1031-1035, 1981.
31. Noda, K., and K. Chikamori. Effect of blood ammonia via prepyriform cortex on regulation of food intake in the rat. Am. J. Physiol. 231: 1263-1266, 1976.
32. Ottersen, O. P. Connections of the amygdala of the rat. IV. Corticoamygdaloid and intraamygdaloid connections as studied with axonal transport of horseradish peroxidase. J. Comp. Neurol. 205: 30-48, 1982.
33. Petrovich, G. D., P. Y. Risold, and L. W. Swanson. Organization of projections from the basomedial nucleus of the amygdala: a PHAL study in the rat. J. Comp. Neurol. 374: 387-420, 1996.
34. Price, J. L., F. T. Russchen, and D. G. Amaral. The limbic region. II. The amygdaloid complex. In: Handbook of Chemical Neuroanatomy, edited by A. Bjorklund, T. Hokfelt, and L. W. Swanson. New York: Elsevier, 1987, vol. 5, pt. I, p. 279-388.
35. Rogers, Q. R., and P. M. B. Leung. The control of food intake: when and how are amino acids involved? In: The Chemical Senses and Nutrition, edited by M. R. Kare and O. Maller. New York: Academic, 1977, p. 213-249.
36. Saper, C. B. Organization of cerebral cortical afferent systems in the rat. II. Hypothalamocortical projections. J. Comp. Neurol. 237: 21-46, 1985.
37. Sawchenko, P. E., and L. W. Swanson. The organization of forebrain afferents to the paraventicular and supraoptic nuclei of the rat. J. Comp. Neurol. 218: 121-144, 1983.
38. Swanson, L. W. The hypothalamus. In: Handbook of Chemical Neuroanatomy, edited by A. Bjorklund, T. Hokfelt, and L. W. Swanson. New York: Elsevier, 1987, vol. 5, pt. I, p. 1-124.
39. Swanson, L. W., and P. E. Sawchenko. Hypothalamic integration: organization of the paraventricular and supraoptic nuclei. Annu. Rev. Neurosci. 6: 269-324, 1983.
40. Ter Horst, G. J., and P. G. M. Luiten. The projections of the dorsomedial hypothalamic nucleus in the rat. Brain Res. Bull. 16: 231-248, 1986.
41. Ter Horst, G. J., and P. G. M. Luiten. Phaeolus vulgaris leuco-agglutinin tracing of intrahypothalamic connections of the lateral, ventromedial, dorsomedial and paraventricular hypothalamic nuclei in the rat. Brain Res. Bull. 18: 191-203, 1987.
42. 3 antagonists block aversion to saccharin in an amino acid-imbalanced diet. Am. J. Physiol. 268 (Regulatory Integrative Comp. Physiol. 37): R1203-R1208, 1995.
43. Thompson, R. H., N. S. Canteras, and L. W. Swanson. Organization of projections from the dorsomedial nucleus of the hypothalamus: a PHA-L study in the rat. J. Comp. Neurol. 376: 143-173, 1996.
44. Thompson, R. H., and L. W. Swanson. Organization of inputs to the the dorsomedial nucleus of the hypothalamus: a reexamination with Flurogold and PHAL in the rat. Brain Res. Rev. 27: 89-118, 1998.
45. Wang, Y., S. L. Cummings, and D. W. Gietzen. Temporalspatial pattern of c-FOS expression in the rat brain in response to indispensable amino acid deficiency. II. The learned taste aversion. Mol. Brain Res. 40: 35-41, 1996.
46. Washburn, B. S., J. C. Jiang, S. L. Cummings, and D. W. Gietzen. Anorectic responses to dietary amino acid imbalance: effects of vagotomy and tropisetron. Am. J. Physiol. 266 (Regulatory Integrative Comp. Physiol. 35): R1922-R1927, 1994.