Future in vitro and animal studies: Development of pharmacokinetic and pharmacodynamic efficacy predictors for tissue-based antibiotics

Pharmacotherapy

Volumn 25, Issue 12 II, 2005, Pages

  Nightingale, Charles H ^a,b  

^a HARTFORD HOSPITAL   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Antibiotics; Efficacy predictors; Pharmacodynamics; Pharmacokinetics

Indexed keywords

ANTIBIOTIC AGENT; AZITHROMYCIN; CLARITHROMYCIN; KETOLIDE; MACROLIDE;

ANTIBIOTIC THERAPY; ANTIMICROBIAL ACTIVITY; AREA UNDER THE CURVE; BACTERICIDAL ACTIVITY; CONFERENCE PAPER; DRUG BLOOD LEVEL; DRUG PENETRATION; DRUG TISSUE LEVEL; EXPERIMENTAL MOUSE; IMMUNE DEFICIENCY; IMMUNOCOMPETENCE; IN VITRO STUDY; LUNG ALVEOLUS MACROPHAGE; LUNG FLUID; MICRODIALYSIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHARMACODYNAMICS; STREPTOCOCCUS PNEUMONIAE; SYSTEMATIC REVIEW;

ANIMALS; ANTI-BACTERIAL AGENTS; AREA UNDER CURVE; LUNG; MICROBIAL SENSITIVITY TESTS; PNEUMONIA, PNEUMOCOCCAL; STREPTOCOCCUS PNEUMONIAE; TISSUE DISTRIBUTION;

EID: 29044438557     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.2005.25.12part2.146S     Document Type: Conference Paper

References (12)

1. Liu P, Muller M, Derendorf H. Rational dosing of antibiotics: the use of plasma concentrations versus tissue concentrations, Int J Antimicrob Agents 2002;19:285-90.
2. Maglio D, Nicolau DP, Nightingale CH. Impact of pharmacodynamics on dosing of macrolides, azalides, and ketolides. Infect Dis Clin North Am 2003;17:563-77.
3. Drusano GL. Antimicrobial pharmacodynamics: critical interactions of "bug and drug." Nat Rev Microbiol 2004;2:289-300.
4. Bradley JS, Dudley MN, Drusano GL. Predicting efficacy of anti-infectives with pharmacodynamics and Monte Carlo simulation. Pediatr Infect Dis J 2003;22:982-92.
5. Detacher S, Derendorf H, Hollenstein U, et al. A combined in vivo pharmacokinetic-in vitro pharmacodynamic approach to simulate target site pharmacodynamics of antibiotics in humans. J Antimicrob Chemother 2000;46:733-9.
6. Muller M, dela Pena A, Derendorf H. Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: kill curves versus MIC. Antimicrob Agents Chemother 2004;48:369-77.
7. Muller M, dela Pena A, Derendorf H. Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: distribution in tissue. Antimicrob Agents Chemother 2004;48:1441-53.
8. Joukhadar C, Derendorf H, Muller M. Microdialysis: a novel tool for clinical studies of anti-infective agents. Eur J Clin Pharmacol 2001;57:211-19.
9. Andes D, Craig WA. Animal model pharmacokinetics and pharmacodynamics: a critical review. Int J Antimicrob Agents 2002;19:261-8.
10. Maglio D, Capitano B, Banavicius MA, Geng Q, Nightingale CH, Nicolau DP. Differential efficacy of clarithromycin in lung vs thigh infection models. Chemotherapy 2004;50:63-6.
11. Bearden DT, Rodvold KA. Penetration of macrolides into pulmonary sites of infection. Infect Med 1999;16(suppl A):480A-4.
12. Mouton JW. Impact of pharmacodynamics on breakpoint selection for susceptibility testing. Infect Dis Clin North Am 2003;17:579-98.