Synthesis and controlled release of biocompatible prodrugs of β-cyclodextrin linked with PEG containing ibuprofen or indomethacin

Iranian Polymer Journal (English Edition)

Volumn 14, Issue 10, 2005, Pages 921-927

  Namazi, Hassan ^a   Bahrami, Seifali ^a   Entezami, Ali Akbar ^a  

^a UNIVERSITY OF TABRIZ   (Iran)

Author keywords

Cyclodextrin; Hydrolysis; Ibuprofen; Indomethacin; Prodrugs

Indexed keywords

BIOCOMPATIBILITY; PH EFFECTS; POLYETHYLENE GLYCOLS; REACTION KINETICS; SYNTHESIS (CHEMICAL); ULTRAVIOLET SPECTROPHOTOMETERS;

CYCLODEXTRIN; IBUPROFEN; INDOMETHACIN; PRODRUGS;

DRUG PRODUCTS;

EID: 29044433374     PISSN: 10261265     EISSN: 10261265     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Stoddart J.F., A novel-approach to the synthesis of some chemically-modified cyclodextrins, J. Org. Chem., 60, 3893-3903 (1995).
2. Breslow R., Halfon S., Zhang B., Molecular recognition by cyclodextrin dimmers, Tetrahedron, 51, 377-388 (1995).
3. Irie T., Uekama K., Pharmaceutical applications of cyclodextrins 3. Toxicological issues and safety evaluation, J. Pharm. Sci., 86, 147-161 (1997).
4. Davaran S., Entezami A., Acrylic type polymers containing ibuprofen and indomethacin with difunctional spacer group: Synthesis and hydrolysis, J. Control. Rci, 47, 41-49 (1997).
5. Harris F. W., Controlled release from polymers containing pendent bioactive substituents In: Medical application of controlled release, Langer R. S., Wise D.L., (eds.) CRC, Boca Raton, Florida (1984).
6. Boudreaux C. J., Bunyard W.C., McCormic C.L., Controlled activity polymer VIII. Copolymers of acrylic acid and isomeric N-alkyl acrylamide with pendent b-naphtol ester moieties: Synthesis and hydrolysis, J. Cont. Rel., 40, 223-233 (1996).
7. Davaran S., Entezami A., Synthesis and hydrolysis of polyurethanes containing ibuprofen pendent groups, J. Bioact. Compat. Polym., 12, 47-58 (1997).
8. Larsen C., Johansen M., Stability kinetic of hydrolysis of metronidazole monosuccinate in aqueous solution and in plasma, Int. J. Pharm., 27, 205-218 (1983).
9. Arshadi R., Polymer synthesis via activated esters: A new dimention of creativity macromolecular chemistry, Adv. Polym. Sci., 111, 1-41 (1993).
10. Hirayama F., Minami K., Uekama K., In-vitro evaluation of biphenylyl acetic acid-beta-cyclodextrin conjugates as colon-targeting prodrug-drug-release behaviour in rat biological media, J. Pharm. Sci., 48, 27-31 (1996).
11. Coats J.H., Easton C.J., Vaneky S.J., May B., Singh P., Licoln S. F., Chiral differentiation in the deacylation of 6A-O-(2-(4-(2-methyl propyl)phenyl) propanoyl)-betacyclodextrin, J. Chem. Soc., Chem. Commun., 759-760 (1991).
12. Coates J. H., Easton C. J., Fryer N. L., Licoln S. F., Complementary diastereoselectivity in the synthesis and hydrolysis of acylated cyclodextrins, Chem. Lett., 1153-1156 (1994).
13. Clare W. G., Brater D. C., Johnson A. R., Goth's Medical Pharmacology, 12 ed., Mosby CV, Washington D.C. (1988).
14. Chang C. H., Sheu Y. M., Hu W. P., Wang L. F., Chen J. S., Synthesis and properties of copolymers from 2-hydroxylethyl methacrylate-linked nonsteroidal agents with methacrylic acid. J. Polym. Sci., 36, 1481-1490 (1998).
15. Larsen C., Johansen M., Macromolecular prodrugs, regeneratio rate of various NSAIDs compounds from their corresponding dextran ester prodrugs in aqueous buffer and in different biological media, Acta. Pharm. Nordica., 2, 57-65 (1989).
16. Namazi H., Babazadeh M., Sarabi A., Entezami A., Synthesis and hydrolysis of acrylic type polymers containing nanosteroidal anti-inflammatory drugs, J. Polym. Mater., 18, 301-312 (2001).