Ethanol administration to cystic fibrosis knockout mice results in increased fatty acid ethyl ester production

Alcoholism: Clinical and Experimental Research

Volumn 29, Issue 11, 2005, Pages 2039-2045

  Blanco, Paola G ^a   Salem, Raneem O ^b   Ollero, Mario ^a   Zaman, Munir M ^a   Cluette Brown, Joanne E ^b   Freedman, Steven D ^a   Laposata, Michael ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Alcohol; CFTR; Fatty Acids; Lipids

Indexed keywords

ALCOHOL; FATTY ACID ESTER; OLEIC ACID;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC PANCREATITIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYSTIC FIBROSIS; GENE MUTATION; INJECTION; KNOCKOUT MOUSE; LIPID ANALYSIS; LIVER; MOUSE; NONHUMAN; PANCREAS; PRIORITY JOURNAL; WILD TYPE;

ANIMALS; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DISEASE MODELS, ANIMAL; ESTERS; ETHANOL; FATTY ACIDS; INJECTIONS, INTRAPERITONEAL; LIVER; MICE; MICE, INBRED CFTR; MICE, KNOCKOUT; MUTATION; OLEIC ACIDS; PANCREAS; PANCREATITIS, ALCOHOLIC;

ANIMALIA;

EID: 29044432395     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.alc.0000187593.86202.e8     Document Type: Article

References (55)

1. Bernhardt TG, Cannistraro PA, Bird DA Doyle KM, Laposata M (1996) Purification of fatty acid ethyl esters by solid-phase extraction and high-performance liquid chromatography. J Chromatogr B Biomed Appl 675:189-196.
2. Best CA, Cluette-Brown JE, Teruya M, Teruya A, Laposata M (2003) Red blood cell fatty acid ethyl esters: a significant component of fatty acid ethyl esters in the blood. J Lipid Res 44:612-620.
3. Bhat HK, Ansari GA (1990) Cholesterol ester hydrolase mediated conjugation of haloethanols with fatty acids. Chem Res Toxicol 3:311-317.
4. Bhura-Bandali FN, Suh M, Paul Man SF, Clandinin MT (2000) The ΔF508 mutation in the cystic fibrosis transmembrane conductance regulator alters control of essential fatty acid utilization in epithelial cells. J Nutr 130:2870-2875.
5. Christophe A, Robberecht E, DeBaets F, Franckx H (1992) Increase of Long Chain Omega-3 Fatty Acids in the Major Serum Lipid Classes of Patients with Cystic Fibrosis. Ann Nutr Metab 36:304-312.
6. Cohn JA, Strong TV, Picciotto MR, Nairn AC, Collins FS, Fitz JG (1993) Localization of the cystic fibrosis transmembrane conductance regulator in human bile duct epithelial cells. Gastroenterology 105:1857-1864.
7. Colombo C, Battezzati PM, Strazzabosco M, Podda M (1998) Liver and biliary problems in cystic fibrosis. Semin Liver Dis 18:227-235.
8. Dan L, Cluette-Brown JE, Kabakibi A, Laposata M (1998) Quantitation of the mass of fatty acid ethyl esters synthesized by Hep G2 cells incubated with ethanol. Alcohol Clin Exp Res 22:1125-1131.
9. Day CP, Bassendine MF (1992) Genetic predisposition to alcoholic liver disease. Gut 33:1444-1447.
10. Doyle KM, Bird DA, al-Salihi S, Hallaq Y, Cluette-Brown JE, Goss KA, Laposata M (1994) Fatty acid ethyl esters are present in human serum after ethanol ingestion. J Lipid Res 35:428-437.
11. Doyle KM, Cluette-Brown JE, Dube DM, Bernhardt TG, Morse CR, Laposata M (1996) Fatty acid ethyl esters in the blood as markers for ethanol intake. Jama 276:1152-1156.
12. Farrell PM, Mischler EH, Engle MJ, Brown DJ, Lau SM (1985) Fatty acid abnormalities in cystic fibrosis. Pediatr. Res 19:104-109.
13. Freedman S, Kern H, Scheele G (2001) Pancreatic acinar cell dysfunction in cftr(-/-) mice is associated with altered luminal pH and endocytosis at the apical plasma membrane. Gastroenterology 121:950-957.
14. Gorski NP, Nouraldin H, Dube DM, Preffer FI, Dombkowski DM, Villa EM, Lewandrowski KB, Weiss RD, Hufford C, Laposata M (1996) Reduced fatty acid ethyl ester synthase activity in the white blood cells of alcoholics. Alcohol Clin Exp Res 20:268-274.
15. Gukovskaya AS, Mouria M, Gukovsky I, Reyes CN, Kasho VN, Faller LD, Pandol SJ (2002) Ethanol metabolism and transcription factor activation in pancreatic acinar cells in rats. Gastroenterology 122:106-118.
16. Haber P, Wilson J, Apte M, Korsten M, Pirola R (1995) Individual susceptibility to alcoholic pancreatitis: still an enigma. J Lab Clin Med 125:305-312.
17. Haber PS, Norris MD, Apte MV, Rodgers SC, Norton ID, Pirola RC, Roberts-Thomson IC, Wilson JS (1999) Alcoholic pancreatitis and polymorphisms of the variable length polythymidine tract in the cystic fibrosis gene. Alcohol Clin Exp Res 23:509-512.
18. Haber PS, Warner R, Seth D, Gorrell MD, McCaughan GW (2003) Pathogenesis and management of alcoholic hepatitis. J Gastroenterol Hepatol 18:1332-1344.
19. Haber PS, Wilson JS, Apte MV, Pirola RC (1993) Fatty acid ethyl esters increase rat pancreatic lysosomal fragility. J Lab Clin Med 121:759-764.
20. Hungund BL, Goldstein DB, Villegas F, Cooper TB (1988) Formation of fatty acid ethyl esters during chronic ethanol treatment in mice. Biochem Pharmacol 37:3001-3004.
21. Kaluzny MA, Duncan LA, Merritt MV, Epps DE (1985) Rapid separation of lipid classes in high yield and purity using bonded phase columns. J Lipid Res 26:135-140.
22. Kaphalia BS, Fritz RR Ansari GA (1997) Purification and characterization of rat liver microsomal fatty acid ethyl and 2-chloroethyl ester synthase and their relationship with carboxylesterase (pI 6.1). Chem Res Toxicol 10:211-218.
23. Kopelman H, Durie P, Gaskin K, Weizman Z, Forstner G (1985) Pancreatic fluid secretion and protein hyperconcentration in cystic fibrosis. N Engl J Med 312:329-334.
24. Lange LG, Sobel BE (1983) Mitochondrial dysfunction induced by fatty acid ethyl esters, myocardial metabolites of ethanol. J Clin Invest 72:724-731.
25. Laposata EA, Lange LG (1986) Presence of nonoxidative ethanol metabolism in human organs commonly damaged by ethanol abuse. Science 231:497-499.
26. Laposata M, Kabakibi A, Walden MP, Cluette-Brown JE, Nanji AA, Refaai MA, Werner J (2000) Differences in the fatty acid composition of fatty acid ethyl esters in organs and their secretions. Alcohol Clin Exp Res 24:1488-1491.
27. Lee MG, Choi JY, Luo X, Strickland E, Thomas PJ, Muallem S (1999) Cystic fibrosis transmembrane conductance regulator regulates luminal Cl-/HCO3- exchange in mouse submandibular and pancreatic ducts. J Biol Chem 274:14670-14677.
28. Mack DR, Traystman MD, Colombo JL, Sammut PH, Kaufman SS, Vanderhoof JA, Antonson DL, Markin RS, Shaw Jr BW, Langnas AN (1995). Clinical denouement and mutation analysis of patients with cystic fibrosis undergoing liver transplantation for biliary cirrhosis. J Pediatr 127:881-887.
29. Maher JJ (2002) Treatment of alcoholic hepatitis. J Gastroenterol Hepatol 17:448-455.
30. Malats N, Casals T, Porta M, Guarner L, Estivill X, Real FX (2001) Cystic fibrosis transmembrane regulator (CFTR) DeltaF508 mutation and 5T allele in patients with chronic pancreatitis and exocrine pancreatic cancer. PANKRAS II Study Group. Gut 48:70-74.
31. Martin S, Zielenski J, Kortan P, Freedman S, Bishop MD, Shea JC, Ross C, Ip WF, Kawasoe J, Corey M et al (2001) CFTR gene mutations in patients with alcohol induced chronic pancreatitis. Ped. Pulmonol. Supplement 22:342.
32. Nakahara T, Hashimoto K, Hirano M, Koll M, Martin CR, Preedy VR (2003) Acute and chronic effects of alcohol exposure on skeletal muscle c-myc, p53, and Bcl-2 mRNA expression. Am J Physiol Endocrinol Metab 285:E1273-1281.
33. Noone PG, Zhou Z, Silverman LM, Jowell PS, Knowles MR, Cohn JA (2001) Cystic fibrosis gene mutations and pancreatitis risk: relation to epithelial ion transport and trypsin inhibitor gene mutations. Gastroenterology 121:1310-1319.
34. Norton ID, Apte MV, Dixson H, Trent RJ, Haber PS, Pirola RC, Wilson JS (1998) Cystic fibrosis genotypes and alcoholic pancreatitis. J Gastroenterol Hepatol 13:496-499.
35. Okazaki K, Uchida K, Ohana M, Nakase H, Uose S, Inai M, Matsushima Y, Katamura K, Ohmori K, Chiba T (2000) Autoimmune-related pancreatitis is associated with autoantibodies and a Th1/Th2-type cellular immune response. Gastroenterology 118:573-581.
36. O'Sullivan BP, Linden MD, Frelinger 3rd AL, Barnard MR, Spencer-Manzon M, Morris JE, Salem RO, Laposata M, Michelson AD (2005) Platelet activation in cystic fibrosis. Blood 105:4635-4641.
37. Pfutzer RH, Tadic SD, Li HS, Thompson BS, Zhang JY, Ford ME, Eagon PK, Whitcomb DC (2002) Pancreatic cholesterol esterase, ES-10, and fatty acid ethyl ester synthase III gene expression are increased in the pancreas and liver but not in the brain or heart with long-term ethanol feeding in rats. Pancreas 25:101-106.
38. Pitchumoni CS (2001) Pathogenesis of alcohol-induced chronic pancreatitis: facts, perceptions, and misperceptions. Surg Clin North Am 81:379-390.
39. Refaai MA, Nguyen PN, Steffensen TS, Evans RJ, Cluette-Brown JE, Laposata M (2002) Liver and adipose tissue fatty acid ethyl esters obtained at autopsy are postmortem markers for premortem ethanol intake. Clin Chem 48:77-83.
40. Riordan JR, Rommens JM Kerem B, Alon N, Rozmahel R, Grzelczak Z, Zielenski J, Lok S, Plavsic N Chou JL et al (1989) Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 245:1066-1073.
41. Salem RO, Refaai MA, Cluette-Brown JE, Russo JW, Laposata M (2001) Fatty acid ethyl esters in liver and adipose tissues as postmortem markers for ethanol intake. Clin Chem 47:722-725.
42. Sarles H, Sahel J (1976) Pathology of chronic calcifying pancreatitis. Am J Gastroenterol 66:117-139.
43. Savolainen VT, Pajarinen J, Perola M, Penttila A, Karhunen PJ (1997) Polymorphism in the cytochrome P450 2E1 gene and the risk of alcoholic liver disease. J Hepatol 26:55-61.
44. Schneider A, Whitcomb DC Singer MV (2002) Animal models in alcoholic pancreatitis-what can we learn? Pancreatology 2:189-203.
45. Seicean A, Grigorescu M (2002) The pathogenesis of chronic alcoholic pancreatitis. Rom J Gastroenterol 11:19-24.
46. Simsek H, Singh M (1990) Effect of prolonged ethanol intake on pancreatic lipids in the rat pancreas. Pancreas 5:401-407.
47. Singh M, Simsek H (1990) Ethanol and the pancreas: current status. Gastroenterology 98:1051-1062.
48. Soderberg BL, Salem RO, Best CA, Cluette-Brown JE, Laposata M (2003) Fatty acid ethyl esters. Ethanol metabolites that reflect ethanol intake. Am J Clin Pathol 119 (Suppl):S94-99.
49. Soderberg BL, Sicinska ET, Blodget E, Cluette-Brown JE, Suter PM, Schuppisser T, Vetter W, Laposata M (1999) Preanalytical variables affecting the quantification of fatty acid ethyl esters in plasma and serum samples. Clin Chem 45:2183-2190.
50. Stranges S, Freudenheim JL, Muti P, Farinaro E, Russell M, Nochajski TH, Trevisan M (2004) Differential effects of alcohol drinking pattern on liver enzymes in men and women. Alcohol Clin Exp Res 28:949-956.
51. Szczepiorkowski ZM, Dickersin GR, Laposata M (1995) Fatty acid ethyl esters decrease human hepatoblastoma cell proliferation and protein synthesis. Gastroenterology 108:515-522.
52. Werner J, Laposata M, Fernandez-del Castillo C, Saghir M, Iozzo RV, Lewandrowski KB, Warshaw AL (1997) Pancreatic injury in rats induced by fatty acid ethyl ester, a nonoxidative metabolite of alcohol. Gastroenterology 113:286-294.
53. Werner J, Saghir M, Fernandez-del Castillo C, Warshaw AL, Laposata M (2001) Linkage of oxidative and nonoxidative ethanol metabolism in the pancreas and toxicity of nonoxidative ethanol metabolites for pancreatic acinar cells. Surgery 129:736-744.
54. Yang B, O'Reilly DA, Demaine AG, Kingsnorth AN (2001) Study of polymorphisms in the CYP2E1 gene in patients with alcoholic pancreatitis. Alcohol 23:91-97.
55. Zeng W, Lee MG, Yan M, Diaz J, Benjamin I, Marino CR, Kopito R, Freedman S, Cotton C, Muallem S et al (1997) Immuno and functional characterization of CFTR in submandibular and pancreatic acinar and duct cells. Am J Physiol 273:C442-C455.