Fatty acid ethyl esters in the blood as markers for ethanol intake

JAMA

Volumn 276, Issue 14, 1996, Pages 1152-1156

  Doyle, Kay M ^a,b   Cluette Brown, Joanne E ^a   Dube, David M ^a   Bernhardt, Thomas G ^a   Morse, Christopher R ^a   Laposata, Michael ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MASSACHUSETTS LOWELL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; FATTY ACID ESTER;

ADULT; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; FEMALE; HUMAN; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SINGLE BLIND PROCEDURE;

EID: 0029781952     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.276.14.1152     Document Type: Article

References (23)

1. Newsome WH, Rattray JBM. The enzymatic esterification of ethanol with fatty acids. Can J Biochem. 1965;43:1223-1233.
2. Patton S, McCarthy RD. Conversion of alcohol to ethyl esters of fatty acids by the lactating goat Nature. 1966;209:616-617.
3. Lange LG, Bergmann SR, Sobel BE. Identification of fatty acid ethyl esters as products of rabbit myocardial ethanol metabolism. J Biol Chem. 1981; 256:12968-12973.
4. Laposata EA, Lange LG. Presence of nonoxidative ethanol metabolism in human organs commonly damaged by ethanol abuse. Science. 1986;231:497-499.
5. Lieber CS, DeCarli LM. Ethanol oxidation by hepatic microsomes: adaptive increase after ethanol feeding. Science. 1968;162:917-918.
6. Lochner A, Cowley R, Brink AJ. Effect of ethanol on metabolism and function of perfused rat heart. Am Heart J. 1969;78:770-780.
7. Raskin NH, Sokoloff L. Enzymes catalyzing ethanol metabolism in neural and somatic tissues of the rat. J Neurochem. 1972;19:273-282.
8. Hamamoto T, Yamada S, Hirayama C. Nonoxidative metabolism of ethanol in the pancreas: implication in alcoholic pancreatic damage. Biochem Pharmacol. 1990;39:241-245.
9. Szczepiorkowski ZM, Dickerson GR, Laposata M. Fatty acid ethyl esters decrease human hepatoblastoma cell proliferation and protein synthesis. Gastroenterology. 1995;108:515-522.
10. Lange LG, Sobel BE. Mitochondrial dysfunction induced by fatty acid ethyl esters, myocardial metabolites of ethanol. J Clin Invest. 1983;72:724-731.
11. Haber PS, Wilson JS, Apte MV, Pirola RC. Fatty acid ethyl esters increase rat pancreatic lysosomal fragility. J Lab Clin Med. 1993;121:259-264.
12. Doyle KM, Bird DA, Al-Salihi S, et al. Fatty acid ethyl esters are present in human serum after ethanol ingestion. J Lipid Res. 1994;35:428-437.
13. Khavari KA, Farber PD. A profile instrument for the quantification and assessment of alcohol consumption: the Khavari Alcohol Test. J Stud Alcohol. 1978;39:1525-1539.
14. Harris JA, Benedict FG. Biometric Studies of Basal Metabolism in Man. Washington, DC: Carnegie Institute of Washington; 1919. Publication No. 279.
15. Schroeder TJ. Alcohol screen. In: Kaplan LA, Pesce AJ, eds. Clinical Chemistry Theory, Analysis and Correlation. St Louis, Mo: CV Mosby Co; 1984: 1332-1336.
16. Bernhardt TG, Cannistraro PA, Bird DA, Doyle KM, Laposata M. Purification of fatty acid ethyl esters by solid phase extraction and HPLC. J Chromatogr B Biomed Appl. 1995;675:189-196.
17. Laposata M, Szczepiorkowshi ZM, Cluette-Brown JE. Fatty acid ethyl esters: non-oridative metabolites of ethanol. Prostaglandins Leukot Essent Fatty Acids. 1995;52:87-91.
18. Aleryani S, Kabakibi A, Cluette-Brown JE, Laposata M. Fatty acid ethyl ester synthase, an enzyme for nonoxidative ethanol metabolism, is present in serum after liver and pancreatic injury. Clin Chem. 1996;42:24-27.
19. Penn R, Worthington DJ. Is serum gamma-glutamyltransferase a misleading test? BMJ. 1983;286: 531-535.
20. Chick J, Kreitman N, Plant M. Mean cell volume and gamma-glutamyl-transpeptidase as markers of drinking in working men. Lancet. 1981;1:1249-1251.
21. Stibler H. Carbohydrate-deficient transferrin in serum: a new marker of potentially harmful alcohol consumption reviewed. Clin Chem. 1991;37: 2029-2037.
22. Eosman AS, Lieber CS. An overview of current and emerging markers of alcoholism. In: Litten RZ, Allen JP, eds. Measuring Alcohol Consumption. Totowa, NJ: Humana Press; 1992:99-134.
23. Mihas AA, Tavassoli M. Laboratory markers of ethanol intake and abuse: a critical appraisal. Am J Med Sci. 1992;303:415-428.