Interleukin-10 and interleukin-18 promoter polymorphisms in an Italian cohort of patients with undifferentiated carcinoma of nasopharyngeal type

Cancer Immunology, Immunotherapy

Volumn 55, Issue 1, 2006, Pages 23-30

  Pratesi, Chiara ^a   Bortolin, Maria Teresa ^a   Bidoli, Ettore ^a   Tedeschi, Rosamaria ^a   Vaccher, Emanuela ^a   Dolcetti, Riccardo ^a   Guidoboni, Massimo ^a   Franchin, Gianni ^a   Barzan, Luigi ^b   Zanussi, Stefania ^a   Caruso, Calogero ^c   De Paoli, Paolo ^a  

^a CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^b Pordenone Hospital   (Italy)

^c UNIVERSITY OF PALERMO   (Italy)

Author keywords

Epstein Barr virus (EBV); Interleukin 10; Interleukin 18; Single nucleotide polymorphisms (SNPs); Undifferentiated carcinoma of nasopharyngeal type (UCNT)

Indexed keywords

CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 18; VIRUS DNA;

ADULT; ALLELE; ARTICLE; CANCER GROWTH; CAUCASIAN; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DNA DETERMINATION; DNA SEQUENCE; EPSTEIN BARR VIRUS; FEMALE; GENETIC ANALYSIS; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IMMUNOGENETICS; MAJOR CLINICAL STUDY; MALE; NASOPHARYNX CARCINOMA; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUALITATIVE ANALYSIS; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; UNDIFFERENTIATED CARCINOMA; VIREMIA;

CARCINOMA; CASE-CONTROL STUDIES; COHORT STUDIES; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INFLAMMATION; INTERLEUKIN-10; INTERLEUKIN-8; ITALY; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; PROMOTER REGIONS (GENETICS); RISK FACTORS;

EID: 28944454612     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-005-0688-z     Document Type: Article

References (41)

1. Agarwal P, Oldenburg MC, Czarneski JE, Morse RM, Hameed MR, Cohen S, Fernandes H (2000) Comparison study for identifying promoter allelic polymorphism in interleukin 10 and tumor necrosis factor alpha genes. Diagn Mol Pathol 9:158-164
2. Baumforth KR, Young LS, Flavell KJ, Constantinidou C, Murray PG (1999) The Epstein-Barr virus and its association with human cancers. Mol Pathol 52:307-322
3. Behars OH, Henson DE, Hutter RVP, Kennedy BJ (1992) Pharynx 33-8. In: manual for staging of cancer. JB Lippincott, Philadelphia
4. Blackwell JM (2001) Genetics and genomics in infectious disease susceptibility. Trends Mol Med 7:521-526
5. Breslow NE, Day NE (1980) Statistical methods in cancer research, vol I. The analysis of case-control studies. IARC Sci Publ 32:335-338
6. Budiani DR, Hutahaean S, Haryana SM, Soesatyo MH, Sosroseno W (2002) Interleukin-10 levels in Epstein-Barr virus-associated nasopharyngeal carcinoma. J Microbiol Immunol Infect 35:265-268
7. Cardoso SM, DeFor TE, Tilley LA, Bidwell JL, Weisdorf DJ, MacMillan ML (2004) Patient interleukin-18 GCG haplotype associates with improved survival and decreased transplant-related mortality after unrelated-donor bone marrow transplantation. Br J Haematol 126:704-710
8. Chan KC, Zhang J, Chan AT, Lei KI, Leung SF, Chan LY, Chow KC, Lo YM (2003) Molecular characterization of circulating EBV DNA in the plasma of nasopharyngeal carcinoma and lymphoma patients. Cancer Res 63:2028-2032
9. Comar M, Simonelli C, Zanussi S, De Paoli P, Vaccher E, Tirelli U, Giacca M (1997) Dynamics of HIV-1 mRNA expression in patients with long-term nonprogressive HIV-1 infection. J Clin Invest 100:893-903
10. Cooke GS, Hill AV (2001) Genetics of susceptibility to human infectious diseases. Nat Rev Genet 2:967-977
11. Crawford DH (2001) Biology and disease associations of Epstein-Barr virus. Philos Trans R Soc Lond B Biol Sci 356:461-473
12. Eskdale J, Kube D, Gallagher G (1996) A second polymorphic dinucleotide repeat in the 5′ flanking region of the human IL10 gene. Immunogenetics 45:82-83
13. Eskdale J, Gallagher G, Verweij CL, Keijsers V, Westendorp RG, Huizinga TW (1998) Interleukin 10 secretion in relation to human IL-10 locus haplotypes. Proc Natl Acad Sci U S A 95:9465-9470
14. Fliss-Jaber L, Houissa-Kastally R, Bouzouita K, Khediri N, Khelifa R (2004) Cytokine and immunoglobulin production by PWM-stimulated peripheral and tumor-infiltrating lymphocytes of undifferentiated nasopharyngeal carcinoma (NPC) patients. BMC Cancer 4(1):68-77
15. Fujieda S, Lee K, Sunaga H, Tsuzuki H, Ikawa H, Fan GK, Imanaka M, Takenaka H, Saito H (1999) Staining of interleukin-10 predicts clinical outcome in patients with nasopharyngeal carcinoma. Cancer 85:1439-1445
16. Giedraitis V, He B, Huang WX, Hillert J (2001) Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation. J Neuroimmunol 112:146-152
17. Haanpaa M, Nurmikko T, Hurme M (2002) Polymorphism of the IL-10 gene is associated with susceptibility to herpes zoster. Scand J Infect Dis 34:112-114
18. Helminen M, Kilpinen S, Virta M, Hurme M (2001) Susceptibility to primary EBV infection is associated with IL-10 gene promoter polymorphism. J Infect Dis 184:777-780
19. Herrmann K, Niedobitek G (2003) Epstein-Barr virus- associated carcinomas: facts and fiction. J Pathol 199:140-145
20. Hohler T, Kruger A, Gerken G (1998) A TNF-alpha promoter polymorphism is associated with chronic hepatitis B infection. Clin Exp Immunol 11:579-582
21. Howell WM, Turner SJ, Bateman AC, Theaker JM (2001) IL-10 promoter polymorphisms influence tumor development in cutaneous malignant melanoma. Genes Immun 2:25-31
22. Hu H, Tang KF, Chua YN, Lu J, Feng P, Chew CT, Chan SH (2004) Expression of interleukin-18 by nasopharyngeal carcinoma cells: a factor that possibly initiates the massive leukocyte infiltration. Hum Pathol 35:722-728
23. Hurme M, Lahdenpohja N, Santtila S (1998) Gene polymorphisms of interleukins 1 and 10 in infectious and autoimmune diseases. Ann Med 30:469-73
24. Janssen R, Grutters JC, Ruven HJ, Zanen P, Sato H, Welsh KI, du Bois RM, van den Bosch JM (2004) No association between interleukin-18 gene polymorphisms and haplotypes in Dutch sarcoidosis patients. Tissue Antigens 63:578-583
25. Karhukorpi J, Karttunen R (2001) Genotyping interleukin-10 high and low producers with single-tube bidirectional allele-specific amplification. Exp Clin Immunogenet 18:67-70
26. Lio D, Scola L, Crivello A, Colonna-Romano G, Candore G, Bonafe M, Cavallone L, Franceschi C, Caruso C (2002) Gender-specific association between -1082 IL-10 promoter polymorphism and longevity. Genes Immun 3:30-33
27. Lo YM, Chan LY, Chan A, Leung S, Lo K, Zhang J, Lee J, Hjelm M, Johnson P, Huang D (1999) Quantitative and temporal correlation between circulating cell-free EBV-DNA and tumor recurrence in nasopharingeal carcinoma. Cancer Res 59:5452-5455
28. Muti G, Klersy C, Baldanti F, Granata S, Oreste P, Pezzetti L, Gatti M, Gargantini L, Caramella M, Mancini V, Gerna G, Morra E (2003) EBV load and IL-10 in EBV-positive and EBV-negative post-transplant lymphoproliferative disorders. Br J Haematol 122:927-33
29. Mutirangura A, Pornthanakasem W, Theamboonlers A, Sriuranpong V, Lertsanguanisinchi P, Yenrudi S, Voravud N, Suphyabun P, Poovorawan Y (1998) Epstein-Barr viral DNA in serum of patients with nasopharingeal carcinoma. Clin Cancer Res 4:665-669
30. Poli F, Nocco A, Berra S, Scalamogna M, Taioli E, Longhi E, Sirchia G (2002) Allele frequencies of polymorphisms of TNFA, IL-6, IL-10 and IFNG in an Italian Caucasian population. Eur J Immunogenet 29:237-240
31. Pratesi C, Bortolin MT, D'Andrea M, Vaccher E, Barzan L, Bidoli E, Tedeschi R, Zanussi S, De Paoli P (2003) Quantitative plasma/serum EBV DNA load by LMP2a determination in an Italian cohort of NPC patients. J Clin Virol 28:155-164
32. Scola L, Crivello A, Marino V, Gioia V, Serauto A, Candore G, Colonna-Romano G, Caruso C, Lio D (2003) IL-10 and TNF-alpha polymorphisms in a sample of Sicilian patients affected by tuberculosis: implication for ageing and life span expectancy. Mech Ageing Dev 124:569-572
33. Shanmugaratnam K, Sobin LH (1991) Histological typing of tumors of the upper respiratory tract and ear. World Health Organization: international histological classification of tumors. Springer Berlin Heidelberg New York
34. Stassen NA, Breit CM, Norfleet LA, Polk HC Jr (2003) IL-18 promoter polymorphisms correlate with the development of post-injury sepsis. Surgery 134:351-356
35. Terwilliger JD, Ott J (1994) Linkage disequilibrium between alleles at marker loci 188-193. In: Handbook of human genetics linkage. The John Hopkins University Press, Baltimore
36. Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV (1997) An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet 24:1-8
37. Uboldi de Capei MU, Dametto E, Fasano ME, Rendine S, Curtoni ES (2003) Genotyping for cytokine polymorphisms: allele frequencies in the Italian population. Eur J Immunogenet 30:5-10
38. Vokes EE, Liebowitz DN, Weichselbaum RR (1997) Nasopharingeal carcinoma. Lancet 350:1087-1091
39. Wu M, Huang S, Shun T, Chang M, Lin M., Wang P, Lin J (2002) TNF-α and IL-10 promoter polymorphisms in EBV-associated gastric carcinoma. J Infect Dis 185:106-109
40. Yao M, Ohshima K, Suzumiya J, Kume T, Shiroshita T, Kikuchi M (1997) Interleukin-10 expression and cytotoxic-T-cell response in Epstein-Barr-virus- associated nasopharyngeal carcinoma. Int J Cancer 72:398-402
41. Zanussi S, Vaccher E, Caffau C, Pratesi C, Crepaldi C, Bortolin MT, Tedeschi R, Politi D, Barzan L, Tirelli U, De Paoli P (2003) Interferon-γ secretion and perforin expression are impaired in CD8+ lymphocytes from patients with UCNT. Cancer Immunol Immunother 52:28-32