Improved solid-phase synthesis of α,α-dialkylated amino acid-rich peptides with antimicrobial activity

Journal of Peptide Research

Volumn 66, Issue 6, 2005, Pages 333-347

  Haynes, S R ^a,b   Hagius, S D ^a   Juban, M M ^a   Elzer, P H ^a   Hammer, R P ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b XAVIER UNIVERSITY   (United States)

Author keywords

, dialkylated amino acids; aminoisobutyric acid; 3 helix; Amphipathic peptides; Antimicrobial; Circular dichroism spectroscopy

Indexed keywords

2 AMINO 2 METHYLPROPIONIC ACID; 4 AMINOPIPERIDINE 4 CARBOXYLIC ACID; ACLPI 10; ACLPI 9; ACLPIDAB 9; ACLPIDAP 9; ACLPIORN 9; AMINO ACID; ANTIINFECTIVE AGENT; CARBOXYLIC ACID DERIVATIVE; IPI 10; IPI 9; IPIDAB 9; IPIDAP 9; IPIORN 9; LYSINE DERIVATIVE; PEPTIDE; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SYNTHESIS; AMINO TERMINAL SEQUENCE; ANTIMICROBIAL ACTIVITY; ARTICLE; CYTOTOXICITY; ESCHERICHIA COLI; MACROPHAGE; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; SOLID PHASE SYNTHESIS; STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTI-BACTERIAL AGENTS; CELLS, CULTURED; CIRCULAR DICHROISM; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; MICROBIAL SENSITIVITY TESTS; PEPTIDE FRAGMENTS; PEPTIDES; PROINSULIN; STAPHYLOCOCCUS AUREUS;

ESCHERICHIA COLI; MURINAE; STAPHYLOCOCCUS AUREUS;

EID: 28944447379     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3011.2005.00312.x     Document Type: Article

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