Investigation of DNA-binding properties of an aminoglycoside-polyamine library using Quantitative Structure-Activity Relationship (QSAR) models

Journal of Chemical Information and Modeling

Volumn 45, Issue 6, 2005, Pages 1854-1863

  Rege, Kaushal ^a   Ladiwala, Asif ^a   Hu, Shanghui ^a,b   Breneman, M ^a   Dordick, Jonathan S ^a,c   Cramer, Steven M ^a  

^a RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^b Research Rensselaer Polytechnic Institute   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; DATA ACQUISITION; DERIVATIVES; DNA; HYDROGEN BONDS; MOLECULAR STRUCTURE;

AMINE CENTRES; DERIVATIZATION; MOLECULAR SIZE; POLYAMINES;

AMINES;

2'-DEOXYADENOSINE; AMINOGLYCOSIDE; DEOXYADENOSINE; DEOXYADENOSINE DERIVATIVE; DNA; LIGAND; POLYAMINE;

ARTICLE; CARBOHYDRATE ANALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG SCREENING; METABOLISM; MOLECULAR GENETICS; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

AMINOGLYCOSIDES; CARBOHYDRATE SEQUENCE; DEOXYADENOSINES; DNA; DRUG EVALUATION, PRECLINICAL; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POLYAMINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 28944444772     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci050082g     Document Type: Conference Paper

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