The chemical development of the commercial route to sildenafil: A case history

Organic Process Research and Development

Volumn 4, Issue 1, 2000, Pages 17-22

  Dale, David J ^a   Dunn, Peter J ^a   Golightly, Clare ^a   Hughes, Michael L ^a   Levett, Philip C ^a   Pearce, Andrew K ^a   Searle, Patricia M ^a   Ward, Gordon ^a   Wood, Albert S ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0038600292     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op9900683     Document Type: Review

References (11)

1. NIH Consensus Development Panel on Impotence. Impotence. JAMA 1993, 270, 83-90.
2. Rajfer, J.; Aronson, W. J.; Bush, P. A.; Dorey, F. J.; Ignarro, L. J. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N. Eng. J. Med. 1992, 326, 90-4. Andersson, K.-E.; Wagner, G. Physiology of the penile erection. Physiol Rev. 1995, 75, 191-236. Burnett, A. L. The role of nitric oxide in the physiology of an erection. Biol. Reprod. 1995, 52, 485-9. Boolell, M.; Allen, M. J.; Ballard, S. A.; Gepi-Attee, S.; Muirhead, G. J.; Naylor, A. M.; Osterloh, I. H.; Gingell, J. C. Sildenafil: an orally active type 5 GMP-specific phosphodiesterase inhibitor of penile erection dysfunction. Int. J. Impot. Res. 1996, 8, 47-52.
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6. Bell, A. S.; Brown, D.; Terrett, N. K. European Patent 0 463 756 A1, 1992.
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8. DSC performed at a scanning rate of 10 °C/min.
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10. Energy based upon 1 mol of the intermedate (1).
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