Synthesis and characterization of orally active nonpeptide vasopressin V2 receptor antagonists

Chemical and Pharmaceutical Bulletin

Volumn 47, Issue 4, 1999, Pages 501-510

  Ohkawa, Takehiko ^a   Zenkoh, Tatsuya ^a   Tomita, Masayuki ^a   Hosogai, Naomi ^a   Hemmi, Keiji ^a   Tanaka, Hirokazu ^a   Setoi, Hiroyuki ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Antagonist; Anti diuretic; Nonpeptide; Vasopressin

Indexed keywords

1 [1 [4 (3 ACETAMIDOPROPOXY)BENZOYL] 4 PIPERIDYL] 1,2,3,4 TETRAHYDRO 2 QUINOLINONE; BENZODIAZEPINE DERIVATIVE; MOZAVAPTAN; N [4 [2,6 DIAZA 6 [2 (4 METHYLPIPERAZINYL) 2 OXOETHYL] 5 OXOBICYCLO[5.4.0]UNDECA 1(7),8,10 TRIEN 2 YL] CARBONYL]PHENYL[2 (4 METHYLPHENYL)PHENYL]FORMAMIDE; RELCOVAPTAN; UNCLASSIFIED DRUG; VASOPRESSIN RECEPTOR ANTAGONIST; VASOPRESSIN V1 RECEPTOR; VASOPRESSIN V2 RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DIURESIS; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; FLUID BALANCE; HYPOTHALAMUS HYPOPHYSIS SYSTEM; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; OSMOREGULATION; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; URINE VOLUME;

EID: 0032924209     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.47.501     Document Type: Article

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