Degradable dextran hydrogels: Controlled release of a model protein from cylinders and microspheres

Journal of Controlled Release

Volumn 60, Issue 2-3, 1999, Pages 211-221

  Franssen, O ^a   Vandervennet, L ^a   Roders, P ^a   Hennink, W E ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Delayed release; Dextran; Hydrogels; Microspheres; Protein release

Indexed keywords

2 HYDROXYETHYL METHACRYLATE; DEXTRAN; IMMUNOGLOBULIN G; MICROSPHERE;

ARTICLE; CROSS LINKING; DISSOLUTION; ENCAPSULATION; HYDROGEL; HYDROLYSIS; PARTICLE SIZE; PH; PRIORITY JOURNAL; PROTEIN SECRETION; SUSTAINED RELEASE FORMULATION;

BIODEGRADATION, ENVIRONMENTAL; CROSS-LINKING REAGENTS; DELAYED-ACTION PREPARATIONS; DEXTRANS; HYDROGELS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; IMMUNOGLOBULIN G; MICROSPHERES; PARTICLE SIZE; POLYMETHACRYLIC ACIDS; SOLUBILITY; TIME FACTORS;

EID: 0032802033     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(99)00074-7     Document Type: Article

References (22)

1. Gombotz W.R., Pettit D.K. Biodegradable polymers for protein and peptide drug delivery. Bioconjugate Chem. 6:1995;332-351.
2. Cheng J., Jo S., Park K. Polysaccharide hydrogels for protein drug delivery. Carbohydrate Polymers. 28:1995;69-76.
3. Burczak K., Gamian E., Kochman A. Long-term in vivo performance and biocompatibility of poly(vinyl alcohol) hydrogel macrocapsules for hybrid-type artificial pancreas. Biomaterials. 17:1996;2351-2356.
4. Quinn C.P., Pathak C.P., Heller A., Hubbell J.A. Photo-crosslinked copolymers of 2-hydroxyethyl methacrylate, poly(ethylene glycol) tetra-acrylate and ethylene dimethacrylate for improving biocompatibility of biosensors. Biomaterials. 16:1995;389-396.
5. Peppas N.A. Hydrogels in Medicine and Pharmacy. I-III:1986;CRC, Boca Raton, FL.
6. Park K., Shalaby W.S.W., Park H. Biodegradable Hydrogels For Drug Delivery. 1993;Technomic, Basel.
7. am Ende M.T., Mikos A.G. Sanders L.M., Hendren R.W. Protein Delivery, Pharmaceutical Biotechnology. 10:1997;139-165 Plenum, New York.
8. Bell C.L., Peppas N.A. Water, solute and protein diffusion in physiologically responsive hydrogels of poly(methacrylic acid-g-ethylene glycol). Biomaterials. 17:1996;1203-1218.
9. Patil N.S., Dordick J.S., Rethwisch D.G. Macroporous poy(sucrose acrylate) hydrogel for controlled release of macromolecules. Biomaterials. 17:1996;2343-2350.
10. am Ende M.T., Peppas N.A. Transport of ionizable drugs and proteins in crosslinked poly(acrylic acid) and poly(acrylic acid-co-2-hydroxyethyl methacrylate) hydrogels. II. Diffusion and release studies. J. Control. Release. 48:1997;47-56.
11. Ficek B.J., Peppas N.A. Novel preparation of poly(vinyl alcohol) microparticles without crosslinking agent for the controlled drug delivery of proteins. J. Control. Release. 27:1993;259-264.
12. Franssen O., Vos O.P., Hennink W.E. Delayed release of a model protein from enzymatically-degrading dextran hydrogels. J. Control. Release. 44:1997;237-245.
13. O. Franssen, R.J.H. Stenekes, W.E. Hennink, Controlled release of a model protein from enzymatically degrading dextran microspheres. J. Control. Release (in press).
14. Hennink W.E., Talsma H., Borchert J.C.H., De Smedt S.C., Demeester J. Controlled release of proteins from dextran hydrogels. J. Control. Release. 39:1996;47-55.
15. van Dijk-Wolthuis W.N.E., van Steenbergen M.J., Hoogeboom C., Tsang S.K.Y., Hennink W.E. Degradation and release behavior of dextran-based hydrogels. Macromolecules. 30:1997;4639-4645.
16. van Dijk-Wolthuis W.N.E., Tsang S.K.Y., Kettenes-van den Bosch J.J., Hennink W.E. A new class of polymerizable dextrans with hydrolyzable groups: hydroxyethyl methacrylated dextran with and without oligolactate spacer. Polymer. 38:1997;6235-6242.
17. van Dijk-Wolthuis W.N.E., van Steenbergen M.J., Underberg W.J.M., Hennink W.E. Degradation kinetics of methacrylated dextrans in aqueous solution. J. Pharm. Sci. 86:1997;413-417.
18. Stenekes R.J.H., Franssen O., van Bommel E.M.G., Crommelin D.J.A., Hennink W.E. The preparation of dextran microspheres in an all-aqueous system: effect of the formulation parameters on particle characteristics. Pharm. Res. 15:1998;555-559.
19. Franssen O., Hennink W.E. A novel preparation method for polymeric microparticles without the use of organic solvents. Int. J. Pharm. 168:1998;1-7.
20. Edmundson I.C. Particle size analysis. Adv. Pharmaceut. Sci. 2:1967;95-179 Academic Press, London.
21. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal. Biochem. 72:1976;248-254.
22. O. Franssen, R.D. van Ooijen, D. de Boer, R.A.A. Maes, W.E. Hennink, Enzymatic degradation of crosslinked dextrans (submitted).