Platelets and platelet function testing in children

Progress in Pediatric Cardiology

Volumn 21, Issue 1, 2005, Pages 63-69

  Rand, Margaret L ^a,b   Kuhle, Stefan ^c  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c STOLLERY CHILDREN S HOSPITAL   (Canada)

Author keywords

Antiplatelet drugs; Hemostasis; Neonates; Pediatric; Platelet function; Platelets

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; CLOPIDOGREL;

ARTERY THROMBOSIS; ATHEROSCLEROTIC PLAQUE; BLEEDING TIME; BLOOD CLOTTING; BLOOD CLOTTING PARAMETERS; FIBRINOLYSIS; FLOW CYTOMETRY; HEMOSTASIS; HUMAN; MEGAKARYOCYTE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTE FUNCTION; THROMBOCYTE RELEASE REACTION; THROMBOCYTE STRUCTURE; THROMBOELASTOGRAPHY; THROMBOEMBOLISM;

EID: 28844453597     PISSN: 10589813     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ppedcard.2005.09.008     Document Type: Article

References (83)

1. A.D. Michelson Platelets 2002 Academic Press San Diego
2. M.L. Rand, R. Leung, and M.A. Packham Platelet function assays Transfus Apheresis Sci 28 2003 307 317
3. P. Gresele C.P. Page V. Fuster J. Vermeylen Platelets in thrombotic and non-thrombotic disorders: pathophysiology, pharmacology and therapeutics 2002 Cambridge University Press Cambridge
4. M. Andrew, and J. Kelton Neonatal thrombocytopenia Clin Perinatol 11 1984 359 391
5. N. Hezard, G. Potron, N. Schlegel, C. Amory, B. Leroux, and P. Nguyen Unexpected persistence of platelet hyporeactivity beyond the neonatal period: a flow cytometric study in neonates, infants and older children Thromb Haemost 90 2003 116 123
6. V. Castle, G. Coates, L.G. Mitchell, H. O'Brodovich, and M. Andrew The effect of hypoxia on platelet survival and site of sequestration in the newborn rabbit Thromb Haemost 59 1988 45 48
7. C.H. Ts'ao, D. Green, and K. Schultz Function and ultrastructure of platelets of neonates: enhanced ristocetin aggregation of neonatal platelets Br J Haematol 32 1976 225 233
8. C.R. Suarez, J. Gonzalez, C. Menendez, J. Fareed, R. Fresco, and J. Walenga Neonatal and maternal platelets: activation at time of birth Am J Hematol 29 1988 18 21
9. K.L. Saving, D.E. Jennings, J.C. Aldag, and R.C. Caughey Platelet ultrastructure of high-risk premature infants Thromb Res 73 1994 371 384
10. Y. Gruel, B. Boizard, F. Daffos, F. Forestier, J. Caen, and J.L. Wautier Determination of platelet antigens and glycoproteins in the human fetus Blood 68 1986 488 492
11. T. Pietrucha, T. Wojciechowski, and J. Greger Differentiated reactivity of whole blood neonatal platelets to various agonists Platelets 12 2001 99 107
12. J. Simak, K. Holada, J. Janota, and Z. Stranak Surface expression of major membrane glycoproteins on resting and TRAP-activated neonatal platelets Pediatr Res 46 1999 445 449
13. T. Kuhne, G. Ryan, and V. Blanchette Platelet-surface glycoproteins in healthy and preeclamptic mothers and their newborn infants Pediatr Res 40 1996 876 880
14. B.E. Kehrel, M. Glauner, S. Roberts, K. Trenkmann, K.J. Clemetson, and U. Nowak-Gottl Platelet functions in children from different ages Blood 98 2001 251a
15. D. Rajasekhar, A.S. Kestin, F.J. Bednarek, P.A. Ellis, M.R. Barnard, and A.D. Michelson Neonatal platelets are less reactive than adult platelets to physiological agonists in whole blood Thromb Haemost 72 1994 957 963
16. S.J. Israels, M. Daniels, and E.M. McMillan Deficient collagen-induced activation in the newborn platelet Pediatr Res 27 1990 337 343
17. B. Shenkman, N. Linder, and N. Savion Increased neonatal platelet deposition on subendothelium under flow conditions: the role of plasma von Willebrand factor Pediatr Res 45 1999 270 275
18. J.A. Katz, J.L. Moake, and P.D. McPherson Relationship between human development and disappearance of unusually large von Willebrand factor multimers from plasma Blood 73 1989 1851 1858
19. S.J. Israels, and M. Andrew Neonatal hemostasis A.L. Bloom C.D. Forbes D.P. Thomas E.G.D. Tuddenham Haemostasis and thrombosis 1994 Churchill Livingstone Edinburgh 1017 1055
20. N. Linder, B. Shenkman, and E. Levin Deposition of whole blood platelets on extracellular matrix under flow conditions in preterm infants Arch Dis Child Fetal Neonatal Ed 86 2002 F127 F130
21. Y. Finkelstein, B. Shenkman, and L. Sirota Whole blood platelet deposition on extracellular matrix under flow conditions in preterm neonatal sepsis Eur J Pediatr 161 2002 270 274
22. L. Gatti, D. Guarneri, M.L. Caccamo, G.A. Gianotti, and A. Marini Platelet activation in newborns detected by flow-cytometry Biol Neonate 70 1996 322 327
23. D. Rajasekhar, M.R. Barnard, F.J. Bednarek, and A.D. Michelson Platelet hyporeactivity in very low birth weight neonates Thromb Haemost 77 1997 1002 1007
24. P. Mankin, J. Maragos, M. Akhand, and K.L. Saving Impaired platelet-dense granule release in neonates J Pediatr Hematol Oncol 22 2000 143 147
25. R. Knofler, G. Weissbach, and E. Kuhlisch Platelet function tests in childhood. Measuring aggregation and release reaction in whole blood Semin Thromb Hemost 24 1998 513 521
26. K.L. Saving, P. Mankin, J. Maragos, D. Adams, and R. Caughy Association of whole blood aggregation response with immunogold-labeled glycoproteins in adult and neonatal platelets Thromb Res 101 2001 73 81
27. S.J. Israels, M.L. Rand, and A.D. Michelson Neonatal platelet function Semin Thromb Hemost 29 2003 363 372
28. S.J. Israels, T. Cheang, C. Roberston, E.M. McMillan-Ward, and A. McNicol Impaired signal transduction in neonatal platelets Pediatr Res 45 1999 687 691
29. J.M. Whaun Platelet function in the neonate: including qualitative platelet abnormalities associated with bleeding J.A. Stockman C. Pochedly Developmental and neonatal hematology 1988 Raven New York, NY 131 144
30. V.S. Blanchette, and M.L. Rand Platelet disorders in newborn infants: diagnosis and management Semin Perinatol 21 1997 53 62
31. M. Alebouyeh, J.M. Lusher, M.R. Ameri, R.K. Evans, and A. Robinson The effect of 5-hydroxytryptamine and epinephrine on newborn platelets Eur J Pediatr 128 1978 163 168
32. D.G. Corby, and T.P. O'Barr Decreased alpha-adrenergic receptors in newborn platelets: cause of abnormal response to epinephrine Dev Pharmacol Ther 2 1981 215 225
33. M.M. Mull, and W.E. Hathaway Altered platelet function in newborns Pediatr Res 4 1970 229 237
34. D.G. Corby, and T.P. O'Barr Neonatal platelet function: a membrane-related phenomenon? Haemostasis 10 1981 177 185
35. S.J. Israels, F.S. Odaibo, C. Robertson, E.M. McMillan, and A. McNicol Deficient thromboxane synthesis and response in platelets from premature infants Pediatr Res 41 1997 218 223
36. S. Tanindi, A.E. Kurekci, V. Koseoglu, M. Kurt, and O. Ozcan The normalization period of platelet aggregation in newborns Thromb Res 80 1995 57 62
37. M. Andrew Developmental hemostasis: relevance to thromboembolic complications in pediatric patients Thromb Haemost 74 1995 415 425
38. M.J. Stuart, J. Dusse, D.A. Clark, and R.W. Walenga Differences in thromboxane production between neonatal and adult platelets in response to arachidonic acid and epinephrine Pediatr Res 18 1984 823 826
39. M.A. Packham, M.L. Rand, and R.L. Kinlough-Rathbone Aggregation P. Gresele C.P. Page V. Fuster J. Vermylen Platelets in thrombotic and non-thrombotic disorders: pathophysiology, pharmacology and therapeutics 2002 Cambridge University Press Cambridge 338 356
40. D. Cox, and D. Fitzgerald Monitoring antiplatelet therapy P. Gresele C.P. Page V. Fuster J. Vermeylen Platelets in thrombotic and non-thrombotic disorders: pathophysiology, pharmacology and therapeutics 2002 Cambridge University Press Cambridge 471 484
41. P. Harrison Platelet function analysis Blood Rev 19 2005 111 123
42. P. Harrison The role of PFA-100 testing in the investigation and management of haemostatic defects in children and adults Br J Haematol 130 2005 3 10
43. S.K. Kundu, E.J. Heilmann, R. Sio, C. Garcia, R.M. Davidson, and R.A. Ostgaard Description of an in vitro platelet function analyzer-PFA-100 Semin Thromb Hemost 21 Suppl 2 1995 106 112
44. M. Andrew, B. Paes, J. Bowker, and P. Vegh Evaluation of an automated bleeding time device in the newborn Am J Hematol 35 1990 275 277
45. M.D. Carcao, V.S. Blanchette, and J.A. Dean The Platelet Function Analyzer (PFA-100): a novel in-vitro system for evaluation of primary haemostasis in children Br J Haematol 101 1998 70 73
46. M. Boudewijns, M. Raes, and V. Peeters Evaluation of platelet function on cord blood in 80 healthy term neonates using the Platelet Function Analyser (PFA-100); shorter in vitro bleeding times in neonates than adults Eur J Pediatr 162 2003 212 213
47. S.J. Israels, T. Cheang, E.M. McMillan-Ward, and M. Cheang Evaluation of primary hemostasis in neonates with a new in vitro platelet function analyzer J Pediatr 138 2001 116 119
48. B. Roschitz, K. Sudi, M. Kostenberger, and W. Muntean Shorter PFA-100 closure times in neonates than in adults: role of red cells, white cells, platelets and von Willebrand factor Acta Paediatr 90 2001 664 670
49. R. Cariappa, T.R. Wilhite, C.A. Parvin, and L. Luchtman-Jones Comparison of PFA-100 and bleeding time testing in pediatric patients with suspected hemorrhagic problems J Pediatr Hematol Oncol 25 2003 474 479
50. J.A. Dean, V.S. Blanchette, and M.D. Carcao von Willebrand disease in a pediatric-based population-comparison of type 1 diagnostic criteria and use of the PFA-100 and a von Willebrand factor/collagen-binding assay Thromb Haemost 84 2000 401 409
51. E.F. Mammen, R.S. Alshameeri, and P.C. Comp Preliminary data from a field trial of the PFA-100 system Semin Thromb Hemost 21 Suppl 2 1995 113 121
52. P.A. Gum, K. Kottke-Marchant, and E.D. Poggio Profile and prevalence of aspirin resistance in patients with cardiovascular disease Am J Cardiol 88 2001 230 235
53. M.J. Alberts, D.L. Bergman, E. Molner, B.D. Jovanovic, I. Ushiwata, and J. Teruya Antiplatelet effect of aspirin in patients with cerebrovascular disease Stroke 35 2004 175 178
54. T. Domi, S.S. Thomas, and M.L. Rand A study of platelet response to aspirin in children with arterial ischemic stroke utilizing the PFA-100 analyzer Stroke 35 2004 P284
55. N. Hezard, D. Metz, and P. Nazeyrollas Use of the PFA-100 apparatus to assess platelet function in patients undergoing PTCA during and after infusion of c7E3 Fab in the presence of other antiplatelet agents Thromb Haemost 83 2000 540 544
56. M. Madan, S.D. Berkowitz, and D.J. Christie Rapid assessment of glycoprotein IIb/IIIa blockade with the platelet function analyzer (PFA-100) during percutaneous coronary intervention Am J Heart 141 2001 226 233
57. J. Koscielny, G.F. von Tempelhoff, and S. Ziemer A practical concept for preoperative management of patients with impaired primary hemostasis Clin Appl Thromb Hemost 10 2004 155 166
58. A.D. Michelson, M.R. Barnard, L.A. Krueger, A.L. Frelinger III, and M.I. Furman Flow cytometry A.D. Michelson Platelets 2002 Academic Press San Diego 297 315
59. J. Dachary-Prigent, J.M. Freyssinet, J.M. Pasquet, J.C. Carron, and A.T. Nurden Annexin V as a probe of aminophospholipid exposure and platelet membrane vesiculation: a flow cytometry study showing a role for free sulfhydryl groups Blood 81 1993 2554 2565
60. M.D. Linden, A.L. Frelinger, M.R. Barnard, K. Przyklenk, M.I. Furman, and A.D. Michelson Application of flow cytometry to platelet disorders Semin Thromb Hemost 30 2004 501 511
61. M.I. Furman, D.J. Kereiakes, and L.A. Krueger Leukocyte-platelet aggregation, platelet surface P-selectin, and platelet surface glycoprotein IIIa after percutaneous coronary intervention: effects of dalteparin or unfractionated heparin in combination with abciximab Am J Heart 142 2001 790 798
62. J.W. Semple, K.A. Siminovitch, and M. Mody Flow cytometric analysis of platelets from children with the Wiskott-Aldrich syndrome reveals defects in platelet development, activation and structure Br J Haematol 97 1997 747 754
63. A.D. Michelson Flow cytometry: a clinical test of platelet function Blood 87 1996 4925 4936
64. S. Vig, A. Chitolie, D.H. Bevan, A. Halliday, and J. Dormandy Thromboelastography: a reliable test? Blood Coagul Fibrinolysis 12 2001 555 561
65. S.C. Kettner, A. Pollak, and M. Zimpfer Heparinase-modified thrombelastography in term and preterm neonates Anesth Analg 98 2004 1650 1652
66. B.E. Miller, J.M. Bailey, and T.J. Mancuso Functional maturity of the coagulation system in children: an evaluation using thrombelastography Anesth Analg 84 1997 745 748
67. E.G. Pivalizza, P.J. Pivalizza, L.I. Gottschalk, S. Kee, P. Szmuk, and D.C. Abramson Celite-activated thrombelastography in children J Clin Anesth 13 2001 20 23
68. B.E. Miller, N.A. Guzzetta, S.R. Tosone, and J.H. Levy Rapid evaluation of coagulopathies after cardiopulmonary bypass in children using modified thromboelastography Anesth Analg 90 2000 1324 1330
69. B.E. Miller, N.A. Guzzetta, and S.R. Tosone Tissue factor-activated thromboelastograms in children undergoing cardiac surgery: baseline values and comparisons Anesth Analg 97 2003 1289 1293
70. B.E. Miller, T. Mochizuki, and J.H. Levy Predicting and treating coagulopathies after cardiopulmonary bypass in children Anesth Analg 85 1997 1196 1202
71. G.D. Williams, S.L. Bratton, N.J. Nielsen, and C. Ramamoorthy Fibrinolysis in pediatric patients undergoing cardiopulmonary bypass J Cardiothorac Vasc Anesth 12 1998 633 638
72. G.D. Williams, S.L. Bratton, E.C. Riley, and C. Ramamoorthy Coagulation tests during cardiopulmonary bypass correlate with blood loss in children undergoing cardiac surgery J Cardiothorac Vasc Anesth 13 1999 398 404
73. U. Cammerer, W. Dietrich, T. Rampf, S.L. Braun, and J.A. Richter The predictive value of modified computerized thromboelastography and platelet function analysis for postoperative blood loss in routine cardiac surgery Anesth Analg 96 2003 51 57 [table of contents]
74. S. Khurana, J.C. Mattson, S. Westley, W.W. O'Neill, G.C. Timmis, and R.D. Safian Monitoring platelet glycoprotein IIb/IIIa-fibrin interaction with tissue factor-activated thromboelastography J Lab Clin Med 130 1997 401 411
75. S.A. Mousa, M.S. Forsythe, and J.M. Bozarth Differential efficacy of different platelet glycoprotein IIb/IIIa antagonists on platelet/fibrin-mediated clot dynamics under different conditions using thrombelastography: the critical need for anticoagulant Coron Artery Dis 13 2002 243 248
76. R.M. Craft, J.J. Chavez, S.J. Bresee, D.C. Wortham, E. Cohen, and R.C. Carroll A novel modification of the Thrombelastograph assay, isolating platelet function, correlates with optical platelet aggregation J Lab Clin Med 143 2004 301 309
77. J.W. Smith, S.R. Steinhubl, and A.M. Lincoff Rapid platelet-function assay: an automated and quantitative cartridge-based method Circulation 99 1999 620 625
78. D.J. Kereiakes, M. Mueller, and W. Howard Efficacy of abciximab induced platelet blockade using a rapid point of care assay J Thromb Thrombolysis 7 1999 265 276
79. S.R. Steinhubl, J.D. Talley, and G.A. Braden Point-of-care measured platelet inhibition correlates with a reduced risk of an adverse cardiac event after percutaneous coronary intervention: results of the GOLD (AU-Assessing Ultegra) multicenter study Circulation 103 2001 2572 2578
80. A.I. Malinin, D. Atar, K.P. Callahan, M.E. McKenzie, and V.L. Serebruany Effect of a single dose aspirin on platelets in humans with multiple risk factors for coronary artery disease Eur J Pharmacol 462 2003 139 143
81. J.C. Wang, D. Aucoin-Barry, and D. Manuelian Incidence of aspirin nonresponsiveness using the Ultegra Rapid Platelet Function Assay-ASA Am J Cardiol 92 2003 1492 1494
82. P. Monagle, A. Chan, P. Massicotte, E. Chalmers, and A.D. Michelson Antithrombotic therapy in children: the Seventh ACCP Conference on antithrombotic and thrombolytic therapy Chest 126 2004 645S 687S
83. S.J. Israels, A.D. Michelson, Antiplatelet therapy in children. Thromb Res in press. doi:10.1016/j.thromres.2004.12.016.