Down's syndrome in childhood acute lymphoblastic leukemia: Clinical characteristics and treatment outcome in four consecutive BFM trials

Leukemia

Volumn 12, Issue 5, 1998, Pages 645-651

  Dordelmann M ^a,i   Schrappe, M ^a   Reiter, A ^a   Zimmermann, M ^a   Graf, N ^b   Schott, G ^c   Lampert, F ^d   Harbott, J ^d   Niemeyer, C ^e   Ritter, J ^f   Dorffel W ^c   Nessler G ^g   Kuhl J ^h   Riehm, H ^a  

^a Depts Pediat Hematol and Oncology   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c Children's Hospital   (Germany)

^d UNIVERSITY HOSPITAL GIESSEN   (Germany)

^e UNIVERSITY OF FREIBURG   (Germany)

^f UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^g Children's Hospital   (Germany)

^h UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

ⁱ HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Acute lymphoblastic leukemia; Childhood; Down's syndrome

Indexed keywords

ANTILEUKEMIC AGENT; ASPARAGINASE; DAUNORUBICIN; METHOTREXATE; PREDNISONE; STEROID;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BONE MARROW DEPRESSION; CANCER SURVIVAL; CARDIOTOXICITY; CLINICAL TRIAL; CYTOGENETICS; DIABETES MELLITUS; DIPLOIDY; DOWN SYNDROME; FEMALE; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; INFANT; INFECTION; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROGNOSIS; REGRESSION ANALYSIS; RETROSPECTIVE STUDY;

EID: 17344365412     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2400989     Document Type: Article

References (15)

1. Avet Loiseau H, Mechinaud F, Harousseau JL. Clonal hematologic disorders in Down syndrome. J Pediatr Hematol Oncol 1995; 17: 19-24.
2. Zipursky A, Poon A, Doyle J. Leukemia in Down syndrome. Pediatr Hematol Oncol 1992; 9: 139-149.
3. Pui CH, Raimondi SC, Borowitz MJ, Land VJ, Behm FG, Pullen DJ, Hancock ML, Shuster JJ, Steuber CP, Crist WM. Immunopheno-types and karyotypes of leukemic cells in children with Down syndrome and acute lymphoblastic leukemia. J Clin Oncol 1993; 11: 1361-1367.
4. Robison LL, Nesbit ME Jr, Sather HN, Level C, Shahidi N, Kennedy A, Hammond D. Down syndrome and acute leukemia in children: a 10-year retrospective survey from Childrens Cancer Study Group. J Pediatr 1984; 105: 235-242.
5. Kalwinsky DK, Raimondi SC, Bunin NJ, Fairclough D, Pui CH, Relling MV, Ribeiro R, Rivera GK. Clinical and biological characteristics of acute lymphocytic leukemia in children with Down syndrome. Am J Med Genet Suppl 1990; 7: 267-271.
6. Ragab AH, Abdel Mageed A, Shuster JJ, Frankel LS, Pullen J, van Eys J, Sullivan MP, Boyett J, Borowitz M, Crist WM. Clinical characteristics and treatment outcome of children with acute lymphocytic leukemia and Down's syndrome. Cancer 1991; 67: 1057-1063.
7. Watson MS, Carroll AJ, Shuster JJ, Steuber CP, Borowitz MJ, Behm FG, Pullen DJ, Land VJ. Trisomy 21 in childhood acute lymphoblastic leukemia. Blood 1993; 82: 3098-3102.
8. Levitt GA, Stiller CA, Chessells JM. Prognosis of Down's syndrome with acute leukaemia. Arch Dis Child 1990; 65: 212-216.
9. Peeters MA, Poon A. Down syndrome and leukemia: unusual clinical aspects and unexpected methotrexate sensitivity. Eur J Pediatr 1987; 146: 416-422.
10. Peelers MA, Poon A, Zipursky A, Lejeune J. Toxicity of leukaemia therapy in children with Down syndrome. Lancet 1986; 2: 1279 (letter).
11. Blatt J, Albo V, Prin W, Orlando S, Wollman M. Excessive chemo-therapy-related myelotoxicity in children with Down syndrome and acute lymphoblastic leukaemia. Lancet 1986; 2: 914 (letter).
12. Garre ML, Relling MV, Kalwinsky D, Dodge R, Cram WR, Abromowitch M, Pui CH, Evans WE. Pharmacokinetics and toxicity of methotrexate in children with Down syndrome and acute lymphocytic leukemia. J Pediatr 1987; 111: 606-612.
13. Ludwig WD, Bartram CR, Ritter J et al. Ambigous phenotypes and genotypes in 16 children as characterized by multiparameter analysis, Blood 1988, 71: 1518-1528.
14. Harbott J, Ritterbach J, Ludwig WD et al. Clinical significance of cytogenetic studies in childhood acute leukemia: experience of the BFM trials. Rec Res Cancer Res 1993; 131: 123-128.
15. Hiddemann W, Wörmann B, Ritter J et al. Frequency and clinical significance of DNA aneuploidy in acute leukemia. Ann NJ Acad Sci 1986; 468: 227-233.