Synovial tissue analysis in clinical trials

Journal of Rheumatology

Volumn 32, Issue 12, 2005, Pages 2481-2484

  Bresnihan, Barry ^a,b   Baeten, Dominique ^c   Firestein, Gary S ^d   FitzGerald, Oliver M ^a,b   Gerlag, Danielle M ^e   Haringman, Jasper J ^e   McInnes, Iain B ^f   Reece, Richard J ^g   Smith, Malcolm D ^h   Ulfgren, Ann Kristin ⁱ   Veale, Douglas J ^a,b   Tak, Paul Peter ^e  

^a ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

^c GHENT UNIVERSITY HOSPITAL   (Belgium)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF AMSTERDAM   (Netherlands)

^f UNIVERSITY OF GLASGOW   (United Kingdom)

^g UNIVERSITY OF LEEDS   (United Kingdom)

^h FLINDERS UNIVERSITY   (Australia)

ⁱ KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Clinical trials; Rheumatoid arthritis; Synovial tissue analysis

Indexed keywords

ARTHROPATHY; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; EVALUATION; HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS; SYNOVITIS; SYNOVIUM;

ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; ARTHROGRAPHY; HUMANS; RANDOMIZED CONTROLLED TRIALS; SYNOVIAL MEMBRANE;

EID: 28844443775     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (35)

1. Tak PP, Bresnihan B. The pathogenesis and prevention of joint damage in rheumatoid arthritis: Advances from synovial biopsy and tissue analysis. Arthritis Rheum 2000;43:2619-33.
2. Youssef PP, Kraan M, Breedveld F, et al. Quantitative microscopic analysis of inflammation in rheumatoid arthritis synovial membrane samples selected at arthroscopy compared with samples obtained blindly by needle biopsy. Arthritis Rheum 1998;41:663-9.
3. Kraan MC, Reece RJ, Smeets TJM, Veale DJ, Emery P, Tak PP. Comparison of synovial tissues from the knee joints and the small joints of rheumatoid arthritis patients. Implications for pathogenesis and evaluation of treatment. Arthritis Rheum 2002;46:2034-8.
4. Rooney M, Condell D, Quinlan W, et al. Analysis of the histologic variation of synovitis in rheumatoid arthritis. Arthritis Rheum 1988;31:956-63.
5. Bresnihan B, Cunnane G, Youssef P, Yanni G, FitzGerald O, Mulherin D. Rheumatoid arthritis: proposals for the evaluation of tissue samples by quantitative analysis. Br J Rheumatol 1998;37:636-42.
6. Dolhain RJ, Ter Haar NT, De Kuiper R, et al. Distribution of T cells and signs of T-cell activation in the rheumatoid joint: implications for semiquantitative comparative histology. Br J Rheumatol 1998;37:324-30.
7. Cunnane G, Bjork L, Ulfgren A-K, et al. Quantitative analysis of synovial membrane inflammation: a comparison between automated and conventional microscopic measurement. Ann Rheum Dis 1999;58:493-9.
8. Kraan M, Haringman JJ, Ahern MJ, Breedveld FC, Smith MD, Tak PP. Quantification of the cell infiltrate in synovial tissue by digital image analysis. Rheumatology Oxford 2000;39:43-9.
9. Walters MT, Smith JL, Moore K, Evans PR, Cawley MI. An investigation of the action of disease modifying antirheumatic drugs on the rheumatoid synovial membrane: reduction in T lymphocyte subpopulations and HLA-DP and DQ antigen expression after gold or penicillamine therapy. Ann Rheum Dis 1987;46:7-16.
10. Rooney M, Whelan A, Feighery C, Bresnihan B. Changes in lymphocyte infiltration of the synovial membrane and the clinical course of rheumatoid arthritis. Arthritis Rheum 1989;32:361-9.
11. Yanni G, Farahat MNMR, Poston RN, Panayi GS. Intramuscular gold decreases cytokine expression and macrophage numbers in the rheumatoid synovial membrane. Ann Rheum Dis 1994;53:315-22.
12. Firestein GS, Paine MM, Boyle DL. Mechanism of methotrexate action in rheumatoid arthritis. Selective decrease in synovial collagenase gene expression. Arthritis Rheum 1994;37:193-200.
13. Dolhain RJEM, Tak PP, Dijkmans BAC, De Kuiper P, Breedveld FC, Miltenburg AMM. Methotrexate treatment reduced inflammatory cell numbers, expression of monokines and of adhesion molecules in synovial tissue of patients with rheumatoid arthritis. Br J Rheumatol 1998;37:502-8.
14. Kane D, Gogarty M, O'Leary J, et al. Methotrexate reduces synovial sub-lining layer inflammation and pro-inflammatory cytokine expression in psoriatic arthritis. Arthritis Rheum 2004;50:3286-95.
15. Youssef PP, Cormack J, Evill CA, et al. Neutrophil trafficking into inflamed joints in patients with rheumatoid arthritis and the effect of methylprednisolone. Arthritis Rheum 1996;39:216-25.
16. Youssef PP, Haynes DR, Triantafillou S, et al. Effects of pulse methylprednisolone on inflammatory mediators in peripheral blood, synovial fluid, and synovial membrane in rheumatoid arthritis. Arthritis Rheum 1997;40:1400-8.
17. Tak PP, Taylor PC, Breedveld FC, et al. Decrease in cellularity and expression of adhesion molecules by anti-tumor necrosis factor alpha monoclonal antibody treatment in patients with rheumatoid arthritis. Arthritis Rheum 1996;39:1077-81.
18. Taylor PC, Peters AM, Paleolog E, et al. Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor blockade in patients with rheumatoid arthritis. Arthritis Rheum 2000;43:38-47.
19. Baeten D, Kruithof E, Van den Bosch F, et al. Immunomodulatory effects of anti-tumor necrosis factor alpha therapy on synovium in spondylarthropathy: histologic findings in eight patients from an open-label pilot study. Arthritis Rheum 2001;44:186-95.
20. Kraan MC, Reece RJ, Barg EC, et al. Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirty-nine patients at two centers. Arthritis Rheum 2000;43:1820-30.
21. Cunnane G, Madigan A, Murphy E, FitzGerald O, Bresnihan B. The effects of treatment with interleukin-1 receptor antagonist on inflamed synovial membrane in rheumatoid arthritis. Rheumatology Oxford 2001;40:62-9.
22. Gerlag DM, Haringman JJ, Smeets TJM, et al. Identification of biomarkers in synovial tissue associated with clinical improvement in rheumatoid arthritis. Arthritis Rheum 2004;50:3783-91.
23. Haringman JJ, Kraan MC, Smeets TJM, Zwinderman KH, Tak PP. Chemokine blockade and chronic inflammatory disease: proof of concept in patients with rheumatoid arthritis. Ann Rheum Dis 2003;62:715-21.
24. Smeets TJM, Kraan MC, van Loon MC, Tak PP. Tumor necrosis factor alpha blockade reduces the synovial cell infiltrate early after initiation of treatment, but apparently not by induction of apoptosis in synovial tissue. Arthritis Rheum 2003;48:2155-62.
25. Boers M, Verhoeven AC, Markusse HM, et al. Randomized comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis. Lancet 1997;350:309-18.
26. Haringman JJ, Gerlag DM, Zwinderman AH, et al. Synovial tissue macrophages: a sensitive biomarker for response to treatment in patients with rheumatoid arthritis. Ann Rheum Dis 2005;64:834-8.
27. Smeets TJM, Kraan MC, Versendaal J, Breedveld FC, Tak PP. Analysis of serial synovial biopsies in patients with RA: Description of a control group without clinical improvement after treatment with interleukin 10 or placebo. J Rheumatol 1999;26:2089-93.
28. Tak PP, Van der Lubbe PA, Cauli A, et al. Reduction of synovial inflammation after anti-CD4 monoclonal antibody treatment in early rheumatoid arthritis. Arthritis Rheum 1995;38:1457-65.
29. Smeets TJM, Dayer JM, Kraan MC, et al. The effects of interferon-beta treatment on synovial inflammation and expression of metalloproteinases in patients with rheumatoid arthritis. Arthritis Rheum 2000;43:270-4.
30. van Holten J, Pavelka K, Vencovsky J, et al. A multicenter, rand omized, double-blind, placebo controlled phase II study of subcutaneously administered interferon beta 1a in the treatment of patients with active rheumatoid arthritis. Ann Rheum Dis 2005;64:64-9. Epub 2004 Jul 8.
31. Yanni G, Whelan A, Feighery C, Bresnihan B. Synovial tissue macrophages and joint erosion in rheumatoid arthritis. Ann Rheum Dis 1994;53:39-44.
32. Mulherin D, FitzGerald O, Bresnihan B. Synovial tissue macrophage populations and articular damage in rheumatoid arthritis. Arthritis Rheum 1996;39:115-24.
33. Cunnane G, FitzGerald O, Beeton C, Cawston TE, Bresnihan B. Early joint erosions and serum levels of matrix metalloproteinase 1, matrix metalloproteinase 3 and tissue inhibitor of metalloproteinases 1 in rheumatoid arthritis. Arthritis Rheum 2001;44:2263-74.
34. Bresnihan B, Youssef P. Macrophages in rheumatoid arthritis. In: Burke B, Lewis CE, editors. The macrophage. Oxford: Oxford University Press;2002:391-433.
35. Kraan MC, Haringman JJ, Weedon H, et al. T cells, fibroblast-like synoviocytes, and granzyme B+ cytotoxic cells are associated with joint damage in patients with recent onset rheumatoid arthritis. Ann Rheum Dis 2004;63:483-8.