Structural basis of the suppressed catalytic activity of wild-type human glutathione transferase T1-1 compared to its W234R mutant

Journal of Molecular Biology

Volumn 355, Issue 1, 2006, Pages 96-105

  Tars, Kaspars ^a   Larsson, Anna Karin ^a   Shokeer, Abeer ^a   Olin, Birgit ^a   Mannervik, Bengt ^a   Kleywegt, Gerard J ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Glutathione transferase; Protein X ray crystallography; Protein ligand interaction; T1 1

Indexed keywords

ARGININE; CARBOXYLIC ACID; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE T1 1; GLUTATHIONE TRANSFERASE T2 2; S HEXYLGLUTATHIONE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DENSITY; ELECTRON; ENZYME MECHANISM; ENZYME REPRESSION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROPHOBICITY; MOLECULAR INTERACTION; MUTANT; PRIORITY JOURNAL; STEREOSPECIFICITY; WILD TYPE;

EID: 28844438404     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2005.10.049     Document Type: Article

References (35)

1. P.D. Josephy Glutathione and detoxication Molecular Toxicology 1997 Oxford University Press New York 152 186
2. U. Rannug, A. Sundvall, and C. Ramel The mutagenic effect of 1,2-dichloroethane on Salmonella typhimurium I. Activation through conjugation with glutathione in vitro Chem. Biol. Interact. 20 1978 1 16
3. N. Ozawa, and F.P. Guengerich Evidence for formation of an S-[2-(N7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA Proc. Natl Acad. Sci. USA 80 1983 5266 5270
4. R. Thier, J.B. Taylor, S.E. Pemble, W.G. Humphreys, M. Persmark, B. Ketterer, and F.P. Guengerich Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes Proc. Natl Acad. Sci. USA 90 1993 8576 8580
5. M. Warholm, C. Guthenberg, B. Mannervik, C. von Bahr, and H. Glaumann Identification of a new glutathione S-transferase in human liver Acta Chem. Scand. B 34 1980 607 621
6. M. Warholm, C. Guthenberg, B. Mannervik, and C. von Bahr Purification of a new glutathione S-transferase (transferase mu) from human liver having high activity with benzo(alpha)pyrene-4,5-oxide Biochem. Biophys. Res. Commun. 98 1981 512 519
7. J. Seidegård, W.R. Vorachek, R.W. Pero, and W.R. Pearson Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion Proc. Natl Acad. Sci. USA 85 1988 7293 7297
8. S. Pemble, K.R. Schroeder, S.R. Spencer, D.J. Meyer, E. Hallier, and H.M. Bolt Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism Biochem. J. 300 1994 271 276
9. A.-S. Johansson, and B. Mannervik Interindividual variability of glutathione transferase expression G.M. Pacifici O. Pelkonen Interindividual Variability of Glutathione Transferase Expression 2001 Taylor & Francis London 460 519
10. S.Z. Abdel-Rahman, W.A. Anwar, W.E. Abdel-Aal, H.M. Mostafa, and W.W. Au GSTM1 and GSTT1 genes are potential risk modifiers for bladder cancer Cancer Detect. Prev. 22 1998 129 138
11. S.K. Park, K.Y. Yoo, S.J. Lee, S.U. Kim, S.H. Ahn, and D.Y. Noh Alcohol consumption, glutathione S-transferase M1 and T1 genetic polymorphisms and breast cancer risk Pharmacogenetics 10 2000 301 309
12. S.J. Lee, S.H. Cho, S.K. Park, S.W. Kim, M.S. Park, and H.Y. Choi Combined effect of glutathione S-transferase M1 and T1 genotypes on bladder cancer risk Cancer Letters 177 2002 173 179
13. A.-K. Larsson, L.O. Emren, W.G. Bardsley, and B. Mannervik Directed enzyme evolution guided by multidimensional analysis of substrate-activity space Protein Eng. Des. Sel. 17 2004 49 55
14. A. Shokeer, A.K. Larsson, and B. Mannervik Residue 234 in glutathione transferase T1-1 plays a pivotal role in the catalytic activity and the selectivity against alternative substrates Biochem. J. 388 2005 387 392
15. J. Rossjohn, W.J. McKinstry, A.J. Oakley, D. Verger, J. Flanagan, and G. Chelvanayagam Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site Structure 6 1998 309 322
16. J.U. Flanagan, J. Rossjohn, M.W. Parker, P.G. Board, and G. Chelvanayagam A homology model for the human theta-class glutathione transferase T1-1 Proteins: Struct. Funct. Genet. 33 1998 444 454
17. G.J. Kleywegt, and T.A. Jones Phi/psi-chology: Ramachandran revisited Structure 4 1996 1395 1400
18. P. Reinemer, H.W. Dirr, R. Ladenstein, J. Schäffer, O. Gallay, and R. Huber The three-dimensional structure of class p glutathione S-transferase in complex with glutathione sulfonate at 2.3 Å resolution EMBO J. 10 1991 1997 2005
19. A.D. Cameron, I. Sinning, G. L'Hermite, B. Olin, P.G. Board, B. Mannervik, and T.A. Jones Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate Structure 3 1995 717 727
20. I. Le Trong, R.E. Stenkamp, C. Ibarra, W.M. Atkins, and E.T. Adman 1.3-A resolution structure of human glutathione S-transferase with S-hexyl glutathione bound reveals possible extended ligandin binding site Proteins: Struct. Funct. Genet. 48 2002 618 627
21. F.P. Guengerich Activation of dihaloalkanes by thiol-dependent mechanisms J. Biochem. Mol. Biol. 36 2003 20 27
22. J.R. Luft, R.J. Collins, N.A. Fehrman, A.M. Lauricella, C.K. Veatch, and G.T. DeTitta A deliberate approach to screening for initial crystallization conditions of biological macromolecules J. Struct. Biol. 142 2003 170 179
23. A.G.W. Leslie Recent changes to the MOSFLM package for processing film and image plate data Joint CCP4/ESF-EAMCB Newsl. Protein Crystallog. 26 1992
24. Z. Otwinowski, and W. Minor Processing of X-ray diffraction data collected in oscillation mode C.W. Carter Jr R.M. Sweet Methods Enzymol. vol. 276 1996 Academic Press New York 307 326
25. P.R. Evans Scala Joint CCP4/ESF-EAMCB Newsl. Protein Crystallog. 33 1997 22 24
26. L.C. Storoni, A.J. McCoy, and R.J. Read Likelihood-enhanced fast rotation functions Acta Crystallog. sect. D 60 2004 432 438
27. J. Navaza AMoRe: an automated package for molecular replacement Acta Crystallog. sect. A 50 1994 157 163
28. G.J. Kleywegt, and T.A. Jones Halloween. Masks and bones S. Bailey R. Hubbard D. Waller From First Map to Final Model. Proceedings of the CCP4 Study Weekend 1994 SERC Daresbury Laboratory Daresbury 59 66
29. T.A. Jones, J.-Y. Zou, S.W. Cowan, and M. Kjeldgaard Improved methods for building protein models in electron density maps and the location of errors in these models Acta Crystallog. sect. A 47 1991 110 119
30. G.N. Murshudov, A.A. Vagin, and E.J. Dodson Refinement of macromolecular structures by the maximum-likelihood method Acta Crystallog. sect. D 53 1997 240 255
31. A. Perrakis, T.K. Sixma, K.S. Wilson, and V.S. Lamzin wARP: improvement and extension of crystallographic phases by weighted averaging of multiple-refined dummy atomic models Acta Crystallog. sect. D 53 1997 448 455
32. G.J. Kleywegt, and T.A. Jones xdlMAPMAN and xdlDATAMAN-programs for reformatting, analysis and manipulation of biomacromolecular electron-density maps and reflection data sets Acta Crystallog. sect. D 52 1996 826 828
33. A.C. Wallace, R.A. Laskowski, and J.M. Thornton LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions Protein Eng. 8 1995 127 134
34. R.W. Hooft, G. Vriend, C. Sander, and E.E. Abola Errors in protein structures Nature 381 1996 272
35. R.A. Engh, and R. Huber Accurate bond and angle parameters for X-ray protein structure refinement Acta Crystallog. sect. A 47 1991 392 400