Iron supplementation may aggravate inflammatory status of colitis in a rat model

Digestive Diseases and Sciences

Volumn 45, Issue 2, 2000, Pages 394-397

  Reifen, Ram ^a,b,c   Matas, Zippora ^a,b   Zeidel, Lilian ^a,b   Berkovitch, Zippi ^a,b   Bujanover, Yoram ^a,b  

^a Central Laboratory   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c WOLFSON MEDICAL CENTER   (Israel)

Author keywords

Colitis; Iron; Oxidative stress; Rats

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLITIS; COLON BIOPSY; COLON MUCOSA; CONTROLLED STUDY; DIET SUPPLEMENTATION; HISTOPATHOLOGY; INFLAMMATION; INFLAMMATORY CELL; IRON THERAPY; LIPID PEROXIDATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; COLITIS; DIETARY SUPPLEMENTS; INTESTINAL MUCOSA; IRON, DIETARY; MALE; MALONDIALDEHYDE; OXIDATIVE STRESS; PEROXIDASE; RATS; RATS, WISTAR;

EID: 0034090320     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005437331967     Document Type: Article

References (13)

1. 1. Grisham MB, Yamada T: Neutrophils nitrogen oxides and inflammatory bowel disease. Ann NY Acad Sci 30-115, 1992
2. 2. Aust SD, Morehouse LA, Thomas CE: Role of metals in oxygen radical reactions. Free Radic Biol Med 1:3-25, 1986
3. 3. Minotti G: Sources and role of iron in lipid peroxidation. Chem Res Toxicol 2:134-146, 1993
4. 4. Vav der Zee J, Krootjes BBH, Chignel CF, Dubbelman TMAR, VanSteveninck J: Hydroxyl radical generation by a light dependent Fenton reaction. Free Radic Biol Med 14:105-113, 1993
5. 5. Halliwel B, Cutteridge JC: Role of free radicals and catalytic metral ions in human disease: An overview. Methods Enzymol 186:1-8, 1990
6. 6. Health and Human Services Committee: Guide for the Care and Use of Laboratory Animals. Publication 85-21. Bethesda, Maryland, National Institutes of Health
7. 7. Bradly PP, Priebat DA, Christensen RD, Rothestein G: Measurement of cutaneous inflammation estimation of neutrophil content with an enzyme marker. J Invest Dermatol 78:206-209, 1982
8. 8. Buege JA, Aust SD: Microsomal lipid peroxidation. Methods Enzymol 52:302-306, 1978
9. 9. Grisham MB: Oxidants and free radicals in inflammatory bowel disease. The Lancet 334:859-861, 1994
10. 10. Dillard CJ, Downey JE, Tappel AL: Effect of antioxidants on lipid peroxidation in iron-loaded rats. Lipids 19:127-133, 1979
11. 11. Dillard CJ, Gavino VC, Tappel AL: Relative antioxidant effectiveness of a tocoperol in iron loaded rats. J Nutr 113:2266-2273, 1983
12. 12. Wu WH, Meydani M, Meydani SN, Burklund PM, Blumberg JB, Munro HN: Effect of dietary iron overload on lipid peroxidation prostaglandin synthesis and lymphocyte proliferation in young and old rats. J Nutr 120:280-289, 1990
13. 13. Babbs CF: Oxygen radicals in ulcerative colitis. Free Radic Biol Med 13:169-181, 1992