Neutrons from fragmentation of light nuclei in tissue-like media: A study with the GEANT4 toolkit

Physics in Medicine and Biology

Volumn 50, Issue 23, 2005, Pages 5493-5507

  Pshenichnov, Igor ^a,b   Mishustin, Igor ^a,c   Greiner, Walter ^a  

^a FRANKFURT INSTITUTE FOR ADVANCED STUDIES   (Germany)

^b INSTITUTE FOR NUCLEAR RESEARCH   (Russian Federation)

^c KURCHATOV INSTITUTE   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTER SIMULATION; HEAVY IONS; MATHEMATICAL MODELS; MONTE CARLO METHODS; TISSUE; TUMORS;

MONTE CARLO MODEL FOR HEAVY-ION THERAPY (MCHIT); NUCLEAR FRAGMENTATION;

NEUTRONS;

CARBON; NEON; PROTON; WATER;

ARTICLE; CALCULATION; CANCER RADIOTHERAPY; FRAGMENTATION REACTION; HEAVY ION RADIATION; MONTE CARLO METHOD; NEUTRON; PRIORITY JOURNAL; RADIATION DOSE DISTRIBUTION; SIMULATION;

CARBON RADIOISOTOPES; CESIUM RADIOISOTOPES; COMPUTER SIMULATION; HEAVY IONS; HUMANS; IONS; MONTE CARLO METHOD; NEON; NEOPLASMS; NEUTRONS; OXYGEN RADIOISOTOPES; PHANTOMS, IMAGING; PHOTONS; PROTONS; RADIOMETRY; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RADIOTHERAPY, HIGH-ENERGY; SOFTWARE; WATER;

EID: 28644441394     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/50/23/005     Document Type: Article

References (45)

1. Agostinelli S et al (GEANT4 Collaboration) 2003 GEANT4: a simulation toolkit Nucl. Instrum. Methods A 506 250-303
2. Archambeau J O, Bennett G W, Levine G S, Cowen R and Akanuma A 1974 Proton radiation therapy Radiology 110 445-57
3. Berger M J 1993 Proton Monte Carlo Transport Program PTRAN National Institute of Standards and Technology Report NISTIR-5113
4. Bondorf J P, Botvina A S, Iljinov A S, Mishustin I N and Sneppen K 1995 Statistical multifragmentation of nuclei Phys. Rep. 257 133-221
5. Bragg W H and Kleemann R 1905 On the alpha particles of radium, and their loss of range in passing through various atoms and molecules Phil. Mag. S.6 10 318-40
6. Brons S, Taucher-Scholz G, Scholz M and Kraft G 2003 A track structure model for simulation of strand breaks in plasmid DNA after heavy ion irradiation Radiat. Environ. Biophys. 42 63-72
7. Brown A and Suit H 2004 The centenary of the discovery of the Bragg peak Radiother. Oncol. 73 265-8
8. Castro J R, Char D H, Petti P L, Daftari I K, Quivey J M, Singh R P, Blakely E A and Phillips T L 1997 15 years experience with helium ion radiotherapy for uveal melanoma Int. J. Radiat. Oncol. Biol. Phys. 39 989-96
9. Castro J R, Linstadt D E, Bahary J P, Petti P L, Daftari I, Collier J M, Gutin P H, Gauger G and Phillips T L 1994 Experience in charged-particle irradiation of tumors of the skull base - 1977-1992 Int. J. Radiat. Oncol. Biol. Phys. 29 647-55
10. Fassó A, Ferrari A, Ranft J and Sala P R 2000 FLUKA: Status and prospective for hadronic applications Proc. of the Monte Carlo 2000 Conference (Lisbon, 23-26 Oct. 2000) ed A Kling, F Barao, M Nakagawa, L Tavora and P Vaz (Berlin: Springer) pp 955-60
11. Fippel M and Soukup M 2004 A Monte Carlo dose calculation algorithm for proton therapy Med. Phys. 31 2263-73
12. Folger G, Ivanchenko V N and Wellisch J P 2004 The binary cascade - nucleon-nuclear reactions Eur. Phys. J. A 21 407-17
13. GEANT4-Documents 2005 http://geant4.web.cern.ch/geant4/G4UsersDocuments/ Overview/html/
14. GEANT4-Webpage 2005 http://geant4.web.cern.ch/geant4/
15. Goosens M and Giani S 1994 GEANT: Detector description and simulation tool CERN Program Library Long Writeup W5013 (Geneva: CERN)
16. Gudowska I, Sobolevsky N, Andreo P, Belkic D and Brahme A 2004 Ion beam transport in tissue-like media using the Monte Carlo code SHIELD-HIT Phys. Med. Biol. 49 1933-58
17. 12C beam Radiat. Prot. Dosirn. 110 595-600
18. Hong L, Goitein M, Bucciolini M, Comiskey R, Gottschalk B, Rosenthal S, Serago C and Urie M 1996 A pencil beam algorithm for proton dose calculations Phys. Med. Biol. 41 1305-30
19. Jäkel O, Krämer M, Karger C P and Debus J 2001 Treatment planning for heavy ion radiotherapy: clinical implementation and application Phys. Med. Biol. 46 1101-16
20. Jäkel O, Schulz-Ertner D, Karger C P, Nikoghosyan A and Debus J 2003 Heavy ion therapy: status and perspectives Technol. Cancer Res. Treat. 2 377-87
21. Jiang H and Paganetti H 2004 Adaptation of GEANT4 to Monte Carlo dose calculations based on CT data Med. Phys. 31 2811-18
22. Kanai T et al 1993 Irradiation of 135 MeV/u carbon and neon beams for studies of radiation biology NIRS-M-92 (HIMAC-004) (NIRS: Chiba)
23. Kraft G 2000 Tumor therapy with heavy charged particles Prog. Part. Nucl. Phys. 45 S473-544
24. Kraft G, Scholz M and Bechthold U 1999 Tumor therapy and track structure Radiat. Environ. Biophys. 38 229-37
25. Krämer M, Jäkel O, Haberer T, Kraft G, Schardt D and Weber U 2000 Treatment planning for heavy-ion radiotherapy: physical beam model and dose optimization Phys. Med. Biol. 45 3299-317
26. Krämer M, Weyrather W K and Scholz M 2003 The increased biological effectiveness of heavy charged particles: from radiobiology to treatment planning Technol. Cancer Res. Treat. 2 427-36
27. Kumamoto Y, Noda Y, Sato Y, Kanai T and Murakami T 2005 Measurements of neutron effective doses and attenuation lengths for shielding materials at the heavy-ion medical accelerator in Chiba Health Phys. 88 469-79
28. Linstadt D E, Castro J R and Phillips T L 1991 Neon ion radiotherapy - results of the phase-I/II clinical-trial Int. J. Radiat. Oncol. Biol. Phys. 20 761-9
29. Medin J and Andreo P 1997 Monte Carlo calculated stopping-power ratios, water/air, for clinical proton dosimetry (50-250 MeV) Phys. Med. Biol. 42 89-105
30. Nose H, Niita K, Hara M, Uematsu K, Azuma O, Miyauchi Y, Komori M and Kanai T 2005 Improvement of three-dimensional Monte Carlo code PHITS for heavy ion therapy J. Nucl. Sci. Tech. 42 250-55
31. Nowakowski V A et al 1991 Uveal melanoma - development of metastases after helium ion irradiation Radiology 178 277-80
32. Orecchia R, Zurlo A, Loasses A, Krengli M, Tosi G, Zurrida S, Zucali P and Veronesi U 1998 Particle beam therapy (hadrontherapy): basis for interest and clinical experience Eur. J. Cancer 34 459-68
33. Paganetti H 2002 Nuclear interactions in proton therapy: dose and relative biological effect distributions originating from primary and secondary particles Phys. Med. Biol. 47 747-64
34. Paganetti H 2004 Four-dimensional Monte Carlo simulation of time-dependent geometries Phys. Med. Biol. 21 N75-81
35. 2 Med. Phys. 30 1926-31
36. Paganetti H, Niemierko A, Ancukiewicz M, Gerweck L E, Goitein M, Loeffler J S and Suit H D 2002 Relative biological effectiveness (RBE) values for proton beam therapy Int. J. Radiat. Oncol. Biol. Phys. 53 407-21
37. Schardt D et al 1996 Nuclear fragmentation of high-energy heavy-ion beams in water Adv. Space Res. 17 87-94
38. Schneider U, Agosteo S, Pedroni E and Besserer J 2002 Secondary neutron dose during proton therapy using spot scanning Int. J. Radiat. Oncol. Biol. Phys. 53 244-51
39. Schulz-Ertner D, Nikoghosyan A, Thilmann C, Haberer Th, Jäkel O, Karger C, Kraft G, Wannenmacher M and Debus J 2004 Results of carbon ion radiotherapy in 152 patients Int. J. Radiat. Oncol. Biol. Phys. 58 631-40
40. Sihver L, Schardt D and Kanai T 1998 Depth-dose distributions of high-energy carbon, oxygen and neon beams in water Japan. J. Med. Phys. 18 1-21
41. Tsujii H et al 2004 Overview of clinical experiences on carbon ion radiotherapy at MRS Radiother. Oncol. 73 S41-9
42. Weisskopf V E and Ewing D H 1940 On the yield of nuclear reactions with heavy elements Phys. Rev. 57 472-85
43. Wilson J W, Townsend L W, Bidasaria H B, Schimmerling W, Wong M and Howard J 1984 Neon-20 depth-dose relations in water Health Phys. 46 1101-11
44. Wilson R R 1946 Radiological use of fast protons Radiology 47 487-91
45. Wroe A J, Cornelius I M and Rosenfeld A B 2005 The role of nonelastic reactions in absorbed dose distributions from therapeutic proton beams in different medium Med. Phys. 32 37-41